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Wyświetlanie 1-10 z 35
Tytuł:
Elevation of plasma fibrinogen in silent myocardial ischaemia
Autorzy:
Grzywacz, Alina
Psuja, Piotr
Zozulińska, Maria
Elikowski, Waldemar
Zawilska, Krystyna
Tematy:
silent myocardial ischaemia
fibrinogen
plasminogen activator inhibitor-1
Pokaż więcej
Wydawca:
Polskie Towarzystwo Biochemiczne
Powiązania:
https://bibliotekanauki.pl/articles/1044459.pdf  Link otwiera się w nowym oknie
Opis:
High plasma levels of fibrinogen and plasminogen activator inhibitor (PAI-1) are reported to be correlated with coronary heart disease. Therefore the level of fibrinogen concentration in plasma was examined and verified for the possible correlation with the previously explored PAI-1 antigen and PAI-1 activity in the pathogenesis of premature atherosclerosis (Grzywaczet al., 1998,Blood Coagul Fibrinol. 9, 245-249). Examination included only men, aged 33-46 years, who were in a stable condition for at least six months after the acute event. They were divided into two subgroups: group A (n = 14)  with and group B (n = 15) without ischaemic changes in 24 h Holter electrocardiogram. The number of involved vessels visible on the coronarography picture was similar in both groups. In the patients of group A the mean level of fibrinogen (3.92 vs 3.23 g/l, P < 0.05) was higher than in the controls (n = 15). No statistically differences were found between group B and control healthy subjects in any of the parameters measured. There were no correlation between fibrinogen concentration and PAI-1 antigen and activity levels, which were elevated in both groups of patients according to our previous study. Our results indicate that elevated levels of plasma fibrinogen and PAI-1 appeared in the group of patients with more severe disease, as revealed by silent myocardial ischaemia.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ischaemic background of brain fog in long-haul COVID-19 : a nuclear magnetic resonance spectroscopy-based metabonomic analysis : preliminary results
Autorzy:
Dorobek, Małgorzata
Walecki, Jerzy
Modrzyńska, Aneta
Sklinda, Katarzyna
Górecki, Andrzej
Mruk, Bartosz
Opis:
Purpose: Long-haul COVID-19 is a condition of unknown background occurring in COVID-19 survivors regardless of the severity of the SARS-CoV-2 infection itself. The aim of the study was to evaluate brain changes in patients suffering from variable symptoms of brain fog after COVID-19. Material and methods: Eleven patients hospitalized due to symptoms of severe brain fog, i.e. insomnia, sudden impairment of cognitive function, headache, and depression, and 14 healthy volunteers underwent brain imaging including MR spectroscopy. Results: Routine MR imaging revealed no specific macroscopic changes in keeping with brain fog. Considering that the clinical manifestation of brain fog is transient, the evaluation of the metabolic status of the brain remained the method of choice. The concentration of the major cerebral metabolites, i.e. NAA, Cho, and Cr, remained stable. However, changes in Glx and Lac concentration were observed in MR spectroscopy. Conclusions: Following results along with clinical course of the brain for imply probable ischaemic background of symptoms.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Distribution of myocardial bridges in domestic pig
Autorzy:
Kosinski, A.
Grzybiak, M.
Kozlowski, D.
Tematy:
distribution
myocardial bridge
domestic pig
pig
heart
ischaemia
morphology
coronary artery
Pokaż więcej
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Powiązania:
https://bibliotekanauki.pl/articles/32013.pdf  Link otwiera się w nowym oknie
Opis:
Localisation and morphology of myocardial bridges in the heart of domestic pig remain an open issue. Since these structures significantly influence haemodynamics in the coronary arteries, their occurance may lead to numerous pathologies. In the examined group of 150 domestic pig’s hearts, myocardial bridges were diagnosed in 47.3% of the material, mostly in males. In majority of cases the bridges were present above the posterior interventricular branch of the right coronary artery, less often above the anterior interventricular branch of the left coronary artery, and seldom above other blood vessels. The presence of myocardial bridges usually referred to the medial and initial segments of the arteries examined.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Application of the 64-slice computed tomography as a diagnostic method in acute posttraumatic ischaemia of the upper limbs : 3 case reports
Autorzy:
Sąsiadek, Marek
Guziński, Maciej
Waliszewska, Marta
Jakubiak, Aleksandra
Opis:
Background: Acute limb ischaemia' is a sudden, rapidly progressing inhibition of blood supply to a limb, characterised by appearance of new symptoms or by aggravation of the already existing ones, which may lead to amputation of the limb. Computed tomography angiography (CTA) performed with a multislice scanner belongs to methods used for arterial imaging in acute limb ischaemia. The main advantages of this method include: short examination time, low invasiveness, and possibility of a multiplanar and multivolume imaging of the vessels and adjacent tissues. Case Reports: We presented 3 cases of acute posttraumatic ischaemia of the upper limbs, diagnosed in the emergency setting with the use of a 64-slice CT scanner. Conclusions: The CTA examination performed with the 64-slice CT unit revealed high effectiveness when used for localisation of vascular pathologies resulting in acute ischaemia of the upper limbs. Owing to this rapid radiological diagnostic method, it is now possible to perform successful limb-saving surgeries and to introduce postoperative monitoring immediately after the procedure.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Identification of optimal reference genes for gene expression studies in a focal cerebral ischaemia model - spatiotemporal effects
Autorzy:
Pomierny, Bartosz
Pera, Joanna
Krzyżanowska, Weronika
Jurczyk, Jakub
Budziszewska, Bogusława
Strach, Beata
Skorkowska, Alicja
Leonovich, Innesa
Opis:
A proper reference gene (RG) is required to reliably measure mRNA levels in biological samples via quantitative reverse transcription PCR (RT-qPCR). Various experimental paradigms require specific and stable RGs. In studies using rodent models of brain ischaemia, a variety of genes, such as β-actin (Actb), hypoxanthine phosphoribosyltransferase 1 (Hprt1), peptidyl-propyl isomerase A (Ppia) and glyceraldehyde-3-phosphate dehydrogenase (Gapdh), are used as RGs. However, most of these genes have not been validated in specific experimental settings. The aim of this study was to evaluate the time- and brain region-dependent expression of RG candidates in a rat model of transient middle cerebral artery occlusion (tMCAO). The following genes were selected: Actb, Hprt1, Ppia, Gapdh, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta (Ywhaz) and beta-2 microglobulin (B2m). Focal cerebral ischaemia was induced by 90 min of tMCAO in male Sprague-Dawley rats. Expression was investigated at four time points (12 and 24 h; 3 and 7 days) and in three brain areas (the frontal cortex, hippocampus and dorsal striatum) within the ischaemic brain hemisphere. The RT-qPCR results were analysed using variance analysis and the ΔCt, GeNorm, NormFinder and BestKeeper methods. Data from these algorithms were ranked using the geometric mean of ranks of each analysis. Ppia, Hprt1 and Ywhaz were the most stable genes across the analysed brain areas and time points. B2m and Actb exhibited the greatest fluctuations, and the results for Gapdh were ambiguous.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Wyświetlanie 1-10 z 35

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