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Tytuł:
The Biological Properties Of Lactoferrin
Autorzy:
Trybek, Grzegorz
Metlerski, Marcin
Szumilas, Kamila
Aniko-Włodarczyk, Magda
Preuss, Olga
Grocholewicz, Katarzyna
Wiszniewska, Barbara
Tematy:
antimicrobial activity
immunomodulatory effect
lactoferrin
Pokaż więcej
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Powiązania:
https://bibliotekanauki.pl/articles/1054782.pdf  Link otwiera się w nowym oknie
Opis:
Lactoferrin (LF) is an iron-binding glycoprotein from the transferrin family, which has been identified in most biological fluids as secretions from exocrine glands and the content of specific granules of neutrophils. It has been reported to have numerous functions. Due to antimicrobial and anti-inflammatory activity, the lactoferrin plays significant role in host defense against infection and extreme inflammation. Recent studies have also demonstrated that LF can protect against cancer in experimental animals and has anticarcinogenic activity in many human tumors. At the cellular level, LF modulates the proliferation, differentiation, maturation, activation, migration and function of immune cells. This review presents the multifunctional roles and specific beneficial properties of lactoferrin.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fecal lactoferrin, a marker of intestinal inflammation in children with inflammatory bowel disease
Autorzy:
Borkowska, Anna
Liberek, Anna
Łuczak, Grażyna
Jankowska, Agnieszka
Plata-Nazar, Katarzyna
Korzon, Maria
Kamińska, Barbara
Tematy:
fecal lactoferrin
inflammatory bowel disease
children
Pokaż więcej
Wydawca:
Polskie Towarzystwo Biochemiczne
Powiązania:
https://bibliotekanauki.pl/articles/1039002.pdf  Link otwiera się w nowym oknie
Opis:
The aim of this study was to analyze the usefulness of fecal lactoferrin in the diagnosis and monitoring of inflammatory bowel disease (IBD) in children. The study included 52 children with IBD (24 with Crohn's disease and 28 with ulcerative colitis) aged between 0.92 and 18 years, and 41 IBD-free controls of similar age. Fecal concentration of lactoferrin was determined with a quantitative immunoenzymatic test. Fecal concentration of lactoferrin in children with IBD was significantly higher than in the controls. The cut-off value of fecal lactoferrin concentration optimally distinguishing between the children with IBD and the controls was identified as 13 μg/g. The sensitivity and specificity of this cut-off value equaled 80.7% and 92.7%, respectively, and its positive and negative prognostic values were 96.8% and 63.3%, respectively. Patients diagnosed with moderate Crohn's disease had significantly higher fecal concentrations of lactoferrin than children with the mild or inactive disease. Similarly, children with moderate ulcerative colitis showed significantly higher fecal concentrations of lactoferrin than individuals with the mild condition. No significant relationship was found between the fecal concentration of lactoferrin and the severity of endoscopic lesions. Patients with IBD and a positive result of fecal occult blood test were characterized by significantly higher concentrations of lactoferrin than the individuals with IBD and a negative result of this test. In conclusion, fecal concentration of lactoferrin seems to be a useful parameter for diagnosis and monitoring of IBD in children.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Lactoferrin-monophosphoryl lipid a complex enhances immunity of mice to Plesiomonas shigelloides CNCTC 138/92
Autorzy:
Chodaczek, Grzegorz
Zimecki, Michal
Lukasiewicz, Jolanta
Lugowski, Czesław
Tematy:
lactoferrin
Plesiomonas shigelloides
adjuvant
monophosphoryl lipid A
Pokaż więcej
Wydawca:
Polskie Towarzystwo Biochemiczne
Powiązania:
https://bibliotekanauki.pl/articles/1040820.pdf  Link otwiera się w nowym oknie
Opis:
Our previous study showed the efficacy of lactoferrin-monophosphoryl lipid A isolated from Hafnia alvei LPS complex (LF-MPLH.a.) as an adjuvant in stimulation of humoral and cellular immune response in mice to conventional antigens and a lower pyrogenicity of the complex as compared with MPLH.a. alone. In the present investigation we demonstrated that LF-MPLH.a. complex enhanced the immunity of BALB/c mice immunized with Plesiomonas shigelloides CNCTC 138/92 bacterial vaccine, against P. shigelloides infection. The adjuvant effect was evidenced by a significant increase of the antigen-specific serum IgG, IgG2a, and IgG1 and elevation of antigen-specific serum IgA concentrations. In addition, application of the adjuvant facilitated better clearance of the bacteria in spleens and livers of infected mice when compared with MPLH.a. alone. These features of the new adjuvant may predispose it for vaccination protocols in humans.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The multi-component causes of late neonatal sepsis - can we regulate them?
Autorzy:
Skowron, Beata
Majka, Grzegorz
Pilarczyk-Żurek, Magdalena
Piwowar, Monika
Baranowska-Chowaniec, Agnieszka
Strus, Magdalena
Opis:
Elucidating the mechanisms of bacterial translocation is crucial for the prevention and treatment of neonatal sepsis. In the present study, we aimed to evaluate the potential of lactoferrin to inhibit the development of late-onset blood infection in neonates. Our investigation evaluates the role of key stress factors leading to the translocation of intestinal bacteria into the bloodstream and, consequently, the development of life-threatening sepsis. Three stress factors, namely weaning, intraperitoneal administration of Gram-positive cocci and oral intake of Gram-negative rods, were found to act synergistically. We developed a novel model of rat pups sepsis induced by bacterial translocation and observed the inhibition of this process by supplementation of various forms of lactoferrin: iron-depleted (apolactoferrin), iron-saturated (hololactoferrin) and manganese-saturated lactoferrin. Additionally, lactoferrin saturated with manganese significantly increases the Lactobacillus bacterial population, which contributes to the fortification of the intestinal barrier and inhibits the translocation phenomenon. The acquired knowledge can be used to limit the development of sepsis in newborns in hospital neonatal intensive care units.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Artificial extracellular matrices of collagen fibrils and lactoferrin as coatings to enhance osteoblast behavior
Autorzy:
Vandorovcova, M.
Bacakova, L.
Dubruel, P.
Douglas, T. E. L.
Tematy:
coating
collagen
osteoblasts
proliferation
extracellular matrix
lactoferrin
Pokaż więcej
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Powiązania:
https://bibliotekanauki.pl/articles/284321.pdf  Link otwiera się w nowym oknie
Opis:
Lactoferrin, a glycoprotein found in milk, has stimulated osteoblast proliferation and differentiation, but has remained relatively unexplored as a biomaterial component. In this study, artificial extracellular matrices consisting of fibrils of collagen type I containing lactoferrin were used as coatings for the biocompatible polymer poly(lactic-co-glycolic acid) (PLGA). The numbers of cells, their viability and proliferation rate were evaluated in various time intervals. Additionally, cell initial spreading area on day 1 was measured. The results show that lactoferrin accelerates fibril-logenesis, leads to increased osteoblast cell numbers 1 and 3 days post-seeding, and encourages their proliferation in each of the tested time intervals.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A high-throughput method for the quantification of iron saturation in lactoferrin preparations
Autorzy:
Majka, Grzegorz
Heczko, Piotr
Brindell, Małgorzata
Stochel, Grażyna
Śpiewak, Klaudyna
Kurpiewska, Katarzyna
Strus, Magdalena
Opis:
Lactoferrin is considered as a part of the innate immune system that plays a crucial role in preventing bac- terial growth, mostly via an iron sequestration mechanism. Recent data show that bovine lactoferrin prevents late-onset sepsis in preterm very low birth weight neonates by serving as an iron chelator for some bacterial strains; thus, it is very important to control the iron saturation level during diet supplementation. An accurate estimation of lactoferrin iron saturation is essential not only because of its clinical appli- cations but also for a wide range of biochemical experi- ments. A comprehensive method for the quantification of iron saturation in lactoferrin preparations was developed to obtain a calibration curve enabling the determination of iron saturation levels relying exclusively on the defined ratio of absorbances at 280 and 466 nm ( A 280/466 ). To achieve this goal, selected techniques such as spectrophotometry, ELISA,and ICP-MS were combined. The ability to obtain samples of lactoferrin with determination of its iron content in a simple and fast way has beenproven tobe veryuseful. Furthermore, a similar approach could easily be implemented to facilitate the determination of iron saturation level for other metalloproteins in which metal binding results in the appearance of a distinct band in the visible part of the spectrum.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
The content of lactoferrin and interleukin-8 in breast milk of patients with lactational mastitis
Autorzy:
Demianchuk, Nataliia
Akimova, Viorika
Soyka, Larysa
Shchurko, Mariia
Lapovets, Lyubov
Lutsiv, Nataliia
Tkachuk, Serhii
Buchko, Olha
Zubchenko, Svitlana
Hayduchok, Ihor
Tematy:
breast milk
interleukin-8
lactational mastitis
lactoferrin
lactostasis
Pokaż więcej
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Powiązania:
https://bibliotekanauki.pl/articles/40417848.pdf  Link otwiera się w nowym oknie
Opis:
Introduction and aim. Information concerning lactoferrin and interleukin-8 (IL-8) local levels in breast milk are not numerous and requires further research. The aim of this study was to determine the content of lactoferrin and interleukin-8 in the breast milk of patients with lactational mastitis, and to identify new potential markers for assessing the activity of the inflammatory process in the mammary gland. Material and methods. This study analyzed the breast milk of 30 women with lactostasis (group I), 37 women with lactational mastitis (group II) and 30 healthy lactating women (age 26±5 years old). The milk content of lactoferrin and interleukin-8 (IL-8) was determined by enzyme-linked immunosorbent assay. Results. The average value of lactoferrin in breast milk of healthy women was 4.78±0.47 mg/mL, exceeding levels in group I 1.8 times (p<0.05). The level of lactoferrin in group II exceeds the control values 3.1 times (p<0.05). The content of IL-8 in breast milk of women in group I was 7.3 times higher than the control (3.63±0.12 pg/mL, p<0.05). In lactational mastitis, the concentration of IL-8 in breast milk exceeded the group I 13.9 times (p<0.05) and was 1.9 times higher than group I (p<0.05). Conclusion. The analysis has revealed an increase of lactoferrin and IL-8 in breast milk of the test groups, which indicates the activation of non-specific protection.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The in vitro effect of bovine lactoferrin on the activity of organ leukocytes in rainbow trout [Oncorhynchus mykiss], European eel [Anguilla anguilla] and wels catfish [Silurus glanis]
Autorzy:
Malaczewska, J
Wojcik, M.
Wojcik, R.
Siwicki, A.K.
Tematy:
fish
rainbow trout
Oncorhynchus mykiss
European eel
Anguilla anguilla
catfish
Silurus glanis
in vitro effect
bovine lactoferrin
lactoferrin
leucocyte
freshwater fish
Pokaż więcej
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Powiązania:
https://bibliotekanauki.pl/articles/30969.pdf  Link otwiera się w nowym oknie
Opis:
Lactoferrin (LF) is a glycoprotein found in milk, neutrophil granules, secretions and selected organs of mammals. Lactoferrin exhibits antibacterial, antiviral, fungicidal, immunoregulatory and other functions. Although fish are devoid of this protein and its cell receptors, LF effect on the immune mechanisms of fish has been demonstrated. The objective of this study was to investigate the effect of bovine lactoferrin, applied in vitro, on the activity of head kidney and spleen leukocytes in three freshwater fish species: rainbow trout (Oncorhynchus mykiss), European eel (Anguilla anguilla) and weis catfish (Silurus glanis). The obtained results validate LF beneficial effect on the respiratory burst of phagocytes in rainbow trout and weis catfish despite the fact that the potential killing activity against Aeromonas hydrophila was not stimulated in any of the studied species. Bovine lactoferrin enhanced the proliferation of T-lymphocytes in rainbow trout and European eel, as well as of B-lymphocytes in rainbow trout.
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 26

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