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Wyświetlanie 1-10 z 13
Tytuł:
Seroprevalence of Antibodies against Borrelia burgdorferi s. l. and Leptospira interrogans s. l. in Cats in district of Brno and its environs, the Czech Republic
Autorzy:
Zakovska, A.
Schanilec, P.
Tremi, F.
Duskova, M.
Agudelo, R.C.F.
Tematy:
feline
Leptospirosis
Lyme borreliosis
ELISA
Microscopic agglutination test
Pokaż więcej
Wydawca:
Instytut Medycyny Wsi
Powiązania:
https://bibliotekanauki.pl/articles/2086007.pdf  Link otwiera się w nowym oknie
Opis:
Objectives. The aim of this study is to evaluate the seroprevalence of antibodies of Borrelia burgdorferi sensu lato (Bbsl) and Leptospira interrogans sensu lato (Lisl) and their possible concurrence in domestic cats living in variable conditions in South Moravia in the district of Brno and its environs. Additional objectives were to discover possible differences in seroprevalence between groups of cats living in different living conditions, and to determine the spectrum of Leptospira serogroups in cats in the same places. Materials and method. A total of 360 blood sera from domestic cats of 3 different sets were collected during the period 2013–2015. All samples were examined using ELISA for the detection of IgM and IgG antibodies against Bbsl, and the microscopic agglutination test (MAT) for the detection of antibodies against 8 serogroups of Lisl. Results. The ELISA method determined 15.8%, 4.8% and 10.3% IgM anti-Borrelia antibodies in the patient group, shelter cats and street cats, respectively. IgG anti-Borrelia antibodies were found in 6.2%, 9.5%, 5.2%, respectively. Antibodies specific for 5 Leptospira serogroups were detected by the use of MAT in 8.8%, 9.5% and 10.3% of cats from the investigated groups. The total positivity of all examined cats for anti-Borrelia antibodies was 18.0% and for anti-Leptospira – 9.2%. Conclusions. Cats can be infected with both Bbsl and Lisl. The obtained results are exclusive to the city of Brno and its environs, and are comparable to the limited previous studies. There is a need for further studies of clinical signs of both infections and the possible transmission of Leptospira by ticks.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Multiple tropical infections hepatitis, malaria, and leptospirosis induced acute kidney injury: a case report
Autorzy:
Bhargav, Ravi
Goel, Kartik
Kumar, Shailesh
Yadav, Rupesh
Gupta, Shubhi
Wydawca:
Towarzystwo Pomocy Doraźnej
Cytata wydawnicza:
Goel, K., Gupta, S., Bhargav, R., Kumar, S., & Yadav, R. (2025). Multiple tropical infections hepatitis, malaria, and leptospirosis induced acute kidney injury: a case report. Critical Care Innovations, 8(1), 33–38.
Opis:
In tropical regions, infections such as malaria, dengue, leptospirosis, scrub typhus, and viral hemorrhagic fevers frequently result in acute kidney injury (AKI). Pathogenesis involves direct damage by pathogens, immune-mediated injury, and systemic hemodynamic changes. We present the case of a 28-year-old male with no known comorbidities admitted with complaints of fever for the past 12 days, yellowish discolouration of sclera, vomiting, abdominal distension, dyspnea, and decrease in urine output. The patient recently travelled to West Bengal (tropical regions) before the symptom onset. The patient was tested positive for Hepatitis A, Plasmodium vivax, and Leptospira. The patient was treated with IV antibiotics (ceftriaxone and doxycycline for 5 days), including coverage for tropical infections such as leptospirosis and antimalarial (IV artesunate for 3 days). The patient had a decrease in urine output with worsening of KFT and fluid overload for which repeated hemodialysis was performed. Renal function did not show improvement. A renal biopsy was performed for persistent AKI. The biopsy was suggestive of acute tubule interstitial nephritis (ATIN) with plasma cell infiltration. The patient was further managed with Inj. Methylprednisolone 1 g and urine output gradually improved. After day 3 of the start of the steroid, the patient’s dyspnea, acidosis, and abdominal distention resolved. The patient was discharged with steroids (prednisolone 40 g with weekly re-straining). At follow-up, the patient was asymptomatic with his normal liver function tests (LFT) and kidney function tests (KFT). This case highlights the complexity of diagnosing and managing AKI induced by tropical fevers. The overlap of infections of malaria, leptospirosis, and hepatitis posed significant diagnostic challenges. Renal biopsy played a crucial role in identifying ATIN as the underlying pathology, guiding the use of immunosuppressive therapy. Early recognition and comprehensive management, including infection-specific treatments and supportive care, are vital to improving outcomes in patients with tropical fever-induced AKI.
Dostawca treści:
Repozytorium Centrum Otwartej Nauki
Artykuł
Tytuł:
Changes in leptospirosis etiology in animals and humans
Autorzy:
Vasylieva, Natalia
Andreychyn, Mykhaylo
Kravchuk, Yulia
Chervinska, Оlena
Iosyk, Iaryna
Tematy:
morbidity
leptospirosis
farm animals
source of infection
small mammals
Pokaż więcej
Wydawca:
Instytut Medycyny Wsi
Powiązania:
https://bibliotekanauki.pl/articles/989991.pdf  Link otwiera się w nowym oknie
Opis:
Introduction. Leptospirosis is endemic in Ternopil region. In Ukraine, the disease is registered in almost all regions, including the Ternopil region. The aim of the research is to study the regularities of epidemic and epizootic processes of leptospirosis, and the circulation of its pathogens among different sources (small mammals, animals) and humans. Materials and method. Etiologic spectrum of leptospirosis registered in Ternopil region in 1972–2016 among small mammals, farm animals and sick people was studied. Results. Due to the analysis of pathogens circulation among different sources (small mammals, animals), as well as the annual morbidity in humans, it was proved that new leptospira serovars are endemic and brought into the regions mostly by farm animals. Farm animals introduce the infection to humans through the environment, sometimes within 3–5-years. The spread was observed of pathogen serovars, which are new in certain areas, among all types of mouse-like small mammals and rats. It was established that livestock and small mammals are parallel reservoirs. Conclusions. In the regions with endemic species, the structural modification in the etiology of leptospirosis in humans is caused by additional reservoirs among animals, as well as the circulation of other pathogen serovars that were absent in the main natural reservoir, i.e. mouse-like small mammals and rats. The constant monitoring of the population, contamination and carrier state of mouse-like small mammals, rats and farm animals, is required In order to predict the future epidemiological situation on leptospirosis among the population and to improve leptospirosis diagnosis.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Beyond serology : saccharide profiling enables identification of antigenically similar Leptospira and prompts re-evaluation of bacterial lipopolysaccharide evolution
Autorzy:
Dubniewicz, Klaudia
Lewicka, Aleksandra J.
Pardyak, Laura
Arent, Zbigniew
Latowski, Dariusz
Łyczakowski, Jan
Opis:
Leptospirosis is a zoonotic infectious disease of growing importance in both human and veterinary medicine. Gram-negative spirochetes of Leptospira are traditionally classified into serovars based on their antigenic identity, which must be ascertained to design effective treatment procedures for humans and appropriate vaccination strategies in pets and livestock. Unfortunately, identifying Leptospira serovars is challenging and currently requires access to a wide panel of reference strains, animal-derived antisera, or monoclonal antibodies. Here, we describe a new method for the identification of Leptospira serovars that is based on monosaccharide composition analysis of the polysaccharide part of bacterial lipopolysaccharide (LPS) structures. Our approach requires no animal sacrifice and can be implemented in any laboratory equipped for chromatographic analysis. An LPS sugar fingerprint that is specific to each bacterial isolate that we studied can be generated. Importantly, sugar profiling of LPS enables distinguishing Leptospira serovars that are antigenically very similar. Using our new approach, we discover that the LPS structures of two cattle pathogens belonging to two different species: Leptospira interrogans and Leptospira borgpetersenii, and to one serovar: Hardjo, can be distinguished despite sharing major similarities. Through extensive phylogenetic analysis, we reveal which specific glycosyltransferases of the LPS biosynthesis rfb locus likely drove the emergence of these similarities and identify a single glycosyltransferase that might have contributed to the formation of saccharide differences in the LPS structure. Our findings have implications for future work on the evolution of bacterial polysaccharide synthesis and highlight the importance of preventing horizontal gene transfer between pathogenic bacteria.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Multiple tropical infections hepatitis, malaria, and leptospirosis induced acute kidney injury: a case report
Autorzy:
Goel, Kartik
Gupta, Shubhi
Bhargav, Ravi
Kumar, Shailesh
Yadav, Rupesh
Tematy:
Tropical infections
acute kidney injury
leptospirosis
malaria
hepatitis
Pokaż więcej
Wydawca:
Towarzystwo Pomocy Doraźnej
Powiązania:
https://bibliotekanauki.pl/articles/59758742.pdf  Link otwiera się w nowym oknie
Opis:
In tropical regions, infections such as malaria, dengue, leptospirosis, scrub typhus, and viral hemorrhagic fevers frequently result in acute kidney injury (AKI). Pathogenesis involves direct damage by pathogens, immune-mediated injury, and systemic hemodynamic changes. We present the case of a 28-year-old male with no known comorbidities admitted with complaints of fever for the past 12 days, yellowish discolouration of sclera, vomiting, abdominal distension, dyspnea, and decrease in urine output. The patient recently travelled to West Bengal (tropical regions) before the symptom onset. The patient was tested positive for Hepatitis A, Plasmodium vivax, and Leptospira. The patient was treated with IV antibiotics (ceftriaxone and doxycycline for 5 days), including coverage for tropical infections such as leptospirosis and antimalarial (IV artesunate for 3 days). The patient had a decrease in urine output with worsening of KFT and fluid overload for which repeated hemodialysis was performed. Renal function did not show improvement. A renal biopsy was performed for persistent AKI. The biopsy was suggestive of acute tubule interstitial nephritis (ATIN) with plasma cell infiltration. The patient was further managed with Inj. Methylprednisolone 1 g and urine output gradually improved. After day 3 of the start of the steroid, the patient’s dyspnea, acidosis, and abdominal distention resolved. The patient was discharged with steroids (prednisolone 40 g with weekly re-straining). At follow-up, the patient was asymptomatic with his normal liver function tests (LFT) and kidney function tests (KFT). This case highlights the complexity of diagnosing and managing AKI induced by tropical fevers. The overlap of infections of malaria, leptospirosis, and hepatitis posed significant diagnostic challenges. Renal biopsy played a crucial role in identifying ATIN as the underlying pathology, guiding the use of immunosuppressive therapy. Early recognition and comprehensive management, including infection-specific treatments and supportive care, are vital to improving outcomes in patients with tropical fever-induced AKI.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Leptospirosis - current risk factors connected with human activity and the environment
Autorzy:
Wasinski, B.
Dutkiewicz, J.
Tematy:
leptospirosis
risk factor
human activity
environment
epidemiology
temperate zone
climate change
pathogenesis
zoonosis
Pokaż więcej
Wydawca:
Instytut Medycyny Wsi
Powiązania:
https://bibliotekanauki.pl/articles/50156.pdf  Link otwiera się w nowym oknie
Opis:
Leptospirosis is a widespread although recently neglected zoonosis recognized worldwide. The disease seems to be underestimated, especially in countries located in the temperate climatic zone. The presented article concerns the main characteristics of leptospirosis and describes formerly known and recently observed environmental, occupational and recreational risk factors significant in the spreading and pathogenesis of the disease. The aspects of epidemiology significant in the temperate climatic zone are emphasized. The majority of cited articles present cases of the disease reported from Europe or North America. Climatic changes (warming) and extreme weather events such as floods are potential risk factors of leptospirosis. Also, some socio-economic phenomena, such as the intensive migration of people resulting in the transfer of the infections acquired in tropical countries, or worsening of economic status in the cities, increase the probability of disease. Apart from the danger connected with rodents, which are the main vectors of leptospires, occurrence of the disease in dogs and cats can generate a higher risk of infection for humans. Infections may also be acquired during various types of agricultural work and during recreational activities, such as swimming. The results of recent investigations show that ticks are also potential vectors of leptospires. The more frequent emergence of leptospirosis in countries located in the temperate climatic zone emphasize the need to verify knowledge related to the risk of its appearance, and to consider this disease during diagnostic processes.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Occurrence of leptospiral infections in swine population in Poland evaluated by ELISA and microscopic agglutination test
Autorzy:
Wasinski, B.
Pejsak, Z.
Tematy:
occurrence
pig
population
Polska
ELISA test
microscopic agglutination test
leptospirosis
animal infection
Leptospira
serogroup
zoonotic disease
Pokaż więcej
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Powiązania:
https://bibliotekanauki.pl/articles/31105.pdf  Link otwiera się w nowym oknie
Opis:
Swine are one of significant reservoirs and sources of Leptospira infections for man. Serological screenings help to effectively control the epidemiological situation in swine herds and to prevent transmission of Leptospira from animals to man. The purpose of this study was to investigate, by the use of serological methods, the prevalence of infections caused by selected Leptospira serogroups in swine population in Poland. A total of 7112 swine serum samples were examined. The samples were collected from January to October 2008 and came from 280 counties situated in all 16 provinces of Poland. All sera were examined preliminary by enzyme-linked immunosorbent assay (ELISA) using heat-stable antigenic preparation. The samples positive or doubtful in ELISA were investigated by microscopic agglutination test (MAT) with use of serovars Icterohaemorrhagiae, Pomona, Canicola, Sejroe, Tarassovi and Grippotyphosa. Of the collected sera examined by ELISA 73 (1.02%) samples were positive, 85 (1.20%) – doubtful and 6954 – negative. Among ELISA-positive and doubtful sera 64 samples (coming from 14 provinces) were recognized in MAT as positive. Among MAT positive samples 42.19% of sera demonstrated titres with serovar Pomona, 32.81% – with Sejroe, 14.06% – with Icterohaemorrhagiae, 6.25% – with Tarassovi, 3.13% – with Grippotyphosa and 1.56% with Canicola.
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 13

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