Temat: lopinavir - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Simultaneous determination of lopinavir, saquinavir and ritonavirin in human plasma using liquid chromatography – ion trap mass spectrometry
Autorzy:: Lipiński, Marcin
Bielawski, Krzysztof P.
Słomińska, Ewa M.
Smoleński, Ryszard T.
Tematy:: antiviral therapy
lopinavir
saquinavir
ritonavir
LC/MS; Pokaż więcej
Wydawca:: Gdański Uniwersytet Medyczny
Powiązania:: https://bibliotekanauki.pl/articles/1891025.pdf Link otwiera się w nowym oknie
Opis:: Background: Lopinavir, saquinavir, and ritonavir are viral protease inhibitors (PIs) developed for and widely used in the therapy of human immunodeficiency virus (HIV)-related disease. These compounds are also active in vitro against the pathogens causing tuberculosis, malaria and coronavirus infections. PIs have been regarded as a platform for the design of inhibitors targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-encoded proteases. This study aimed to develop a liquid chromatography/mass spectrometry (LC/MS) procedure for accurate simultaneous determination of concentrations of these three PIs in the plasma. Methods: Samples of human plasma were protein precipitated with 0.3 M zinc sulfate in a water/methanol solution (30:70, v/v). The extracts were analyzed with reversed-phase chromatography coupled with the electrospray ionization (ESI) source of the ion trap mass detector operating in mEass spectrometry (MS) and tandem mass spectrometry (MS/MS) modes. Results: Calibration curves demonstrated good linearity from 0.01 to 10 µg/mL and acceptable reproducibilities and recoveries. Conclusions: The described procedure proves that a very basic ion-trap LC/MS system could be applied for selective, rapid, and precise determination of antiviral protease inhibitors.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: X-ray diffraction and vibrational spectroscopic studies of the intermolecular interactions on the grinding and compaction behaviours of lopinavir and ritonavir crystals
Autorzy:: Ainurofiq, Ahmad
Setianto, Arif B.
Nugraha, Yuda P.
Suendo, Veinardi
Uekusa, Hidehiro
Soewandhi, Sundani N.
Tematy:: compression
grinding
Vibrational spectroscopy
Ritonavir
intermolecular interactions lopinavir
crystal behaviour; Pokaż więcej
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Powiązania:: https://bibliotekanauki.pl/articles/895537.pdf Link otwiera się w nowym oknie
Opis:: Lopinavir (LPV) and ritonavir (RTV) are anti-viral drugs used in combination and commonly prepared through hot-melt extrusion techniques. Mechanical processes are greatly involved, including blending and milling. Therefore, the crystal behaviour of LPV and RTV under the mechanical process is an interesting study. Here, the LPV, RTV, and their mixtures were processed by two different treatments: grinding and compression processes. The solid-state properties of the drugs were evaluated by powder x-ray diffraction (PXRD), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, and scanning electron microscopy (SEM). Single-crystal XRD analysis was also carried out to confirm the packing structure in the crystal lattice. It was observed that LPV was very sensitive to the grinding process, where it tends to form an amorphous solid in both the pure and mixture forms. On the other hand, RTV has a very stable crystalline structure and was able to retain its crystallinity even under grinding. Both LPV and RTV were observed to be quite stable under compression, where both retained their crystalline form with only slight changes in their d-spacing values. This study highlighted the molecular origin of LPV and RTV crystal behaviour after grinding and compression processes.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Electrospun amorphous solid dispersions with lopinavir and ritonavir for improved solubility and dissolution rate
Autorzy:: Rezka, Aleksandra
Łyszczarz, Ewelina
Majda, Dorota
Sosna, Oskar
Mendyk, Aleksander
Srebro, Justyna
Opis:: Lopinavir (LPV) and ritonavir (RTV) are two of the essential antiretroviral active pharmaceutical ingredients (APIs) characterized by poor solubility. Hence, attempts have been made to improve both their solubility and dissolution rate. One of the most effective approaches used for this purpose is to prepare amorphous solid dispersions (ASDs). To our best knowledge, this is the first attempt aimed at developing ASDs via the electrospinning technique in the form of fibers containing LPV and RTV. In particular, the impact of the various polymeric carriers, i.e., Kollidon K30 (PVP), Kollidon VA64 (KVA), and Eudragit® E100 (E100), as well as the drug content as a result of the LPV and RTV amorphization were investigated. The characterization of the electrospun fibers included microscopic, DSC, and XRD analyses, the assessment of their wettability, and equilibrium solubility and dissolution studies. The application of the electrospinning process led to the full amorphization of both the APIs, regardless of the drug content and the type of polymer matrix used. The utilization of E100 as a polymeric carrier for LPV and KVA for RTV, despite the beads-on-string morphology, had a favorable impact on the equilibrium solubility and dissolution rate. The results showed that the electrospinning method can be successfully used to manufacture ASDs with poorly soluble APIs.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 4.

Tytuł:: The impact of the core-shell fiber composition on the properties and stability of the electrospun films
Autorzy:: Łyszczarz, Ewelina
Mendyk, Aleksander
Jamróz, Witold
Majda, Dorota
Rezka, Aleksandra
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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