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Wyszukujesz frazę "metastasis" wg kryterium: Temat


Tytuł:
A long clinical course with late distant metastases from follicular thyroid carcinoma
Autorzy:
Erok, Berrin
Harmancı, Kemal
Aksaray, Ferdi
Unlu, Nazmi Uğur
Aydın, Seckin
Tematy:
follicular thyroid carcinoma
brain metastasis
skull metastasis
Pokaż więcej
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Powiązania:
https://bibliotekanauki.pl/articles/2040497.pdf  Link otwiera się w nowym oknie
Opis:
Introduction. Follicular thyroid carcinoma (FTC) accounts for 10-20% of the differentiated thyroid carcinomas (DTCs), and it is the second most common thyroid malignancy after papillary thyroid carcinoma (PTC). FTC is typically more common in women and in older age group than PTC. Unlike PTC, FTC metastases late to the lymph nodes, with only up to 10-20% of the patients having nodal metastases at the time of diagnosis.On the other hand, distant metastasis via hematogenous spread is more likely in patients with FTC due to the invasion of blood vessels. Prognosis depends on the extent of the distant metastasis which drop 10-year survival significantly. Aim. Although DTCs have usually favorable prognosis, metastatic disease in these patients has a long clinical course. Cranial imaging in these patients should be performed during the follow-up after the treatment of FTC with thyroidectomy and RAI. Description of the case. We report a case of late onset but catastrophic hematogenous distant metastases beginning 8 years after the diagnosis & treatment of FTC and becommimg widespread during the following 10 years with a long clinical course in a 60 year old female patient. Conclusion. In the RAI refractory metastatic lesions SRS and surgical resections should be conserned as the first management approach to improve survival.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cutaneous cervical metastasis from an esophageal adenocarcinoma mimicking a dental cervical cellulitis: A case report
Autorzy:
Arnal-Etienne, Andrea
Fourneau, Eleonore
Dewaele, Nathan
Mengeot, Nathalie
Magremanne, Michele
Tematy:
esophageal adenocarcinoma
neck cutaneous metastasis
skin metastasis
Pokaż więcej
Wydawca:
Presses Universitaires de Louvain
Powiązania:
https://bibliotekanauki.pl/articles/48516608.pdf  Link otwiera się w nowym oknie
Opis:
Cutaneous metastases occur in 0.5 to 9% of all cancers. Esophageal cancer is one of the most aggressive cancers worldwide. Most cutaneous metastases from esophageal cancer were related to squamous cell carcinomas. Few cases have been described about cutaneous metastases related to esophageal adenocarcinomas. These metastases mostly affect patients over 60 years-old, and present as cutaneous asymptomatic nodules. A 69-year-old male presented with a painless and extensive left neck cutaneous induration and erythema. The lesion that was initially diagnosed as a dental cervical cellulitis by his dental practitioner. The patient was known since 2019 to suffer from a esophageal adenocarcinoma whose first treatment was surgery. The patient was currently under immunotherapy for a local recurrence. We firstly assessed the uncommon cervical cellulitis by carrying out an injected head and neck computed tomography (CT) scan which showed an unspecific skin, dermal and muscular infiltration of the left cervical region. The 18-FDG PET/CT demonstrated a suspicious fixation of the neck that was followed by a skin biopsy. The histological and immunohistochemical examination showed the metastatic adenocarcinomatous origin of the cervical skin lesion. The patient was upstaged to a stage IV of his esophageal cancer and started palliative chemotherapy. Special attention must be paid in case of diffuse cervical skin infiltrations, even in the presence of a dental infection, in patients with cancer, in order to perform the correct diagnosis.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Metastases of malignant neoplasms to the hand
Autorzy:
Żyluk, Andrzej
Fliciński, Filip
Tematy:
distant metastasis
hand tumor
malignant neoplasm
metastasis to the hand
Pokaż więcej
Wydawca:
Index Copernicus International
Powiązania:
https://bibliotekanauki.pl/articles/58545272.pdf  Link otwiera się w nowym oknie
Opis:
Introduction: Metastases of malignant neoplasms to the hand are very rare and constitute approximately 0.01% of whole distant metastases. They usually indicate generalized neoplastic disease, although sometimes can be a first manifestation of dissemination. Cases reports: The study presents 4 cases of metastatic tumors to the hands in patients with diagnosis of renal (2) and lung cancer (1) and one of unknown point of origin. The lesions were localized in the fingers in two patients and in the wrist in the other two. The patient with wrist involvement received excisional biopsy of the lesion, followed by forearm amputation. Two patients with finger tumors had their affected fingers amputated. The patient with the cyst involving the wrist received local excision of the lesion. Operative wounds healed uneventfully in all patients, but 3 of them eventually died within one year from hand operation.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Paraplegia as a rare presentation of nasopharyngeal carcinoma
Porażenie kończyn dolnych jako nietypowa manifestacja raka jamy nosowo-gardłowej
Autorzy:
Mohamad, Adam
Devi Susibalan, Bathma
Mohamad, Irfan
Tematy:
PET scan
metastasis
nasopharyngeal carcinoma
Pokaż więcej
Wydawca:
Medical Communications
Powiązania:
https://bibliotekanauki.pl/articles/1035536.pdf  Link otwiera się w nowym oknie
Opis:
Nasopharyngeal carcinoma is a common encounter in otorhinolaryngology. It is a non-lymphomatous squamous cell carcinoma that occurs in the epithelial lining of the nasopharynx and shows varying degrees of differentiation. The aetiology is multifactorial. The disease is more common in the Chinese, those exposed to Epstein–Barr virus and in individuals with environmental factors, such as cigarette smoking, consumption of salted fish or preserved vegetables containing volatile nitrosamine, and exposure to industrial fumes or household smoke. Signs and symptoms include neck swelling, hearing loss, nasal blockage, epistaxis, cranial nerve palsy, headache, neck pain, earache or discomfort, weight loss and central nervous system manifestation when distant metastasis is present. Amongst these manifestations, 60% of patients will present with cervical lymphadenopathy followed by epistaxis which occurs in 40% of cases. However, distant site involvement uncommonly becomes the sole presenting symptom. We report a 58-year-old Chinese patient with nasopharyngeal carcinoma who presented with bilateral lower limb weakness. The patient was initially seen by an orthopaedic surgeon, with various radiological investigations conducted, including magnetic resonance imaging. Metastatic lesions were detected at the lumbar vertebra, sacrum and iliac bone. After positron emission tomography, a suspicious primary malignant lesion was detected in the nasopharynx and its biopsy confirmed the diagnosis of nasopharyngeal carcinoma. The patient was referred to the oncology team for definitive treatment, but refused further therapy.
Rak jamy nosowo-gardłowej to często spotykany nowotwór w praktyce lekarza otorynolaryngologa. Jest to nielimfoidalny rak płaskonabłonkowy rozwijający się w warstwie nabłonkowej jamy nosowo-gardłowej i wykazujący różne stopnie zróżnicowania. Etiologia jest wieloczynnikowa. Częściej chorują Chińczycy, a inne czynniki, np. zakażenie wirusem Epsteina–Barr oraz czynniki środowiskowe, takie jak palenie tytoniu, spożywanie peklowanych ryb lub warzyw konserwowych zawierających lotne nitrozoaminy, a także ekspozycja na opary przemysłowe lub pochodzące z gospodarstw domowych, mogą dodatkowo predysponować do rozwoju choroby. Rak nosogardła objawia się obrzękiem szyi, utratą słuchu, niedrożnością nosa, krwawieniem z nosa, porażeniem nerwów czaszkowych, bólem głowy i szyi, bólem lub uczuciem dyskomfortu w uchu i utratą masy ciała, a także dolegliwościami ze strony ośrodkowego układu nerwowego w przypadku przerzutów odległych. Występują powiększone węzły chłonne szyjne (u 60% chorych), a następnie krwawienie z nosa (w 40% przypadków). Niemniej przerzuty odległe rzadko powodują jedyne pierwsze objawy choroby. Przedstawiamy przypadek 58-letniego pacjenta narodowości chińskiej z rakiem jamy nosowo-gardłowej manifestującym się obustronnym osłabieniem kończyn dolnych. Początkowo pacjent zgłosił się do ortopedy, który zlecił różne badania radiologiczne, w tym badanie rezonansem magnetycznym. Zmiany przerzutowe wykryto w obrębie kręgów lędźwiowych, kości krzyżowej i kości biodrowej. Pozytonowa tomografia emisyjna wykazała obecność podejrzanej pierwotnej zmiany złośliwej w jamie nosowo-gardłowej, a biopsja potwierdziła rozpoznanie raka nosogardła. Pacjent został skierowany na oddział onkologiczny celem leczenia radykalnego, lecz odmówił dalszej terapii.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Metastasis of hepatocellular carcinoma to the palatine tonsil – a case report
Autorzy:
Niemczyk, Wiktor
Majszyk, Daniel
Bruzgielewicz, Antoni
Tematy:
hepatocellular carcinoma
metastasis
palatine tonsil
Pokaż więcej
Wydawca:
Index Copernicus International
Powiązania:
https://bibliotekanauki.pl/articles/58927900.pdf  Link otwiera się w nowym oknie
Opis:
Introduction: Tumor metastases to the palatine tonsil are rare, accounting for only 0.8% of all malignant tumors of the palatine tonsil. According to the National Cancer Registry, 743 new cases of malignant tumors of the palatine tonsil (C09) were detected in Poland in 2021, including 526 cases in men and 217 cases in women. This paper describes a rare case of hepatocellular carcinoma (HCC) metastasis to the palatine tonsil in a 48-year-old male patient. Case study: The patient presented to the Department of Otolaryngology, Head and Neck Surgery at the Medical University of Warsaw (MUW) complaining of a sensation of obstruction within the throat. Thirteen months earlier, the patient had undergone liver transplantation due to cirrhosis caused by chronic hepatitis C virus (HCV) infection, which was complicated by HCC. The patient was referred for urgent computed tomography (CT) of the head which revealed a tumor in the right palatine tonsil. An urgent bilateral tonsillectomy was performed. Postoperative histopathological examination confirmed a metastasis of HCC. Conclusions: The pathway of HCC metastasis to the oral cavity is unclear, with one hypothesis suggesting the migration of cancer cells bypassing the lungs via paravertebral Batson veins. The mean survival time of patients with metastases to the tonsil is approximately 9 months regardless of the primary tumor site, and the mean survival time after HCC metastasis to the oral cavity is 21 weeks.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Accuracy of diffusion-weighted imaging in discriminating atypical vertebral haemangiomas from malignant masses in patients with vertebral lesions : a cross-sectional study
Autorzy:
Zarrintan, Armin
Khamanian, Jhila
Ghaderi, Payam
Daghighi, Mohammad Hossein
Yazdaninia, Iman
Daghighi, Shadi
Hajalioghli, Parisa
Ghaffari, Jaber
Mirza-Aghazadeh-Attari, Mohammad
Opis:
Purpose: Vertebral haemangiomas are incidental findings in imaging modalities. Atypical haemangiomas are haemangiomas rich in vascular tissue, and they are found to be hypointense in T1 sequences and hyperintense in T2 sequences, mimicking the findings of metastatic lesions. In the present study we aim to evaluate the ability of diffusionweighted imaging to differentiate these two groups of vertebral lesions. Material and methods: In the present cross-sectional study, a total of 23 lesions were included, including 10 haemangiomas and 13 malignant lesions. Diffusion-weighted imaging was used to compare atypical haemangiomas and metastatic lesions. The apparent diffusion co-efficient was determined for each lesion, and then the mean of each group was calculated. The means were then compared. Receiver operating characteristic analysis was used to determine a cut-off ADC value to differentiate these lesions. Results: The difference between the mean age of the two groups was not significant. The mean ADC value for atypical haemangiomas was 1884 ± 74 × 10-6 mm2/s and 1008 ± 81 × 10-6 mm2/s for the malignant lesions. The difference between the two groups was statistically significant (p < 10-3). ROC curve analysis determined an ADC value of 958 × 10-6 mm2/s to be able to differentiate between atypical haemangiomas and malignant lesions. Conclusions: Diffusion-weighted MRI could be used to differentiate between atypical haemangiomas and malignant metastatic lesions.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Disseminated pancreatic neuroendocrine neoplasm (NEN) with an uncommon localisation in the central nervous system : a case report
Autorzy:
Białkowska, Joanna
Kolasińska-Ćwikła, Agnieszka
Sowa, Mariusz
Cichocki, Andrzej
Maksymowicz, Wojciech
Mroczkowska, Dorota
Ćwikła, Jarosław B.
Grabarczyk, Łukasz
Opis:
BACKGROUND: Neuroendocrine neoplasms (NEN) are rare neoplasms that originate from neuroendocrine cells and are characterized by the potential of hormonal activity. Approximately 70% of these tumours are located in the gastrointestinal system (GI), followed by the bronchi, endocrine glands-like C cells of the thyroid (medullary carcinoma), the parasympathetic and sympathetic system (paragangliomas, pheochromocytoma) and other very rare locations. The prevalence of cerebral metastases in neuroendocrine tumours is estimated by various authors to be approximately 1.5-5%. When the primary tumour is located in the pancreas, it is associated with a risk of cerebral metastases lower than 2%. CASE REPORT: We describe a patient with a disseminated pancreatic NEN that presented with an isolated lesion in the brain. We gathered the important data via medical history,, observation, analysis of medical records, imaging and others diagnostic tests. Despite the fairly rare prevalence of cerebral metastases in NENs, a neurological work-up should be performed. This should include neuroimaging of the brain, preferably with MR, together with the somatostatin receptor scintigraphy (SRS), in each clinically suspicious case. A histopathological examination of the CNS tumour can confirm a dedifferentiation of NEN in the direction of a neuroendocrine carcinoma (NEC - neuroednocrine carcinoma) with a poor prognosis. CONCLUSIONS: Cerebral metastases are diagnosed in 1.5-5% of patients with a neuroendocrine neoplasm. In each case suggestive of a dissemination into the central nervous system, MRI of the brain should be performed.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Silver nanoparticles inhibit metastasis of 4T1 tumor in mice after intragastric but not intravenous administration
Autorzy:
Kapka-Skrzypczak, Lucyna
Kucińska, Małgorzata
Wojewódzka, Maria
Urbańska, Krystyna
Brzóska, Kamil
Kruszewski, Marcin
Biela, Ewa
Michalczyk-Wetula, Dominika
Elas, Martyna
Szczygieł, Małgorzata
Piotrowska-Kempisty, Hanna
Murias, Marek
Śniegocka, Martyna
Drzał, Agnieszka
Opis:
The potential anticancer activity of different silver nanoformulations is increasingly recognized. In the present work, we use the model of 4T1 tumor in BALB/ccmdb immunocompetent mice to analyze the impact of citrate- and PEG-coated silver nanoparticles (AgNPs) on the development and metastatic potential of breast cancer. One group of mice was intragastrically administered with 1 mg/kg body weight (b.w.) of AgNPs daily from day 1 to day 14 after cancer cells implantation (total dose 14 mg/kg b.w.). The second group was intravenously administered twice with 1 or 5 mg/kg b.w. of AgNPs. A tendency for lowering tumor volume on day 21 (mean volumes 491.31, 428.88, and 386.83 $mm^{3}$ for control, AgNPs-PEG, and AgNPs-citrate, respectively) and day 26 (mean volumes 903.20, 764.27, and 672.62 $mm^{3}$ for control, AgNPs-PEG, and AgNPs-citrate, respectively) has been observed in mice treated intragastrically, but the effect did not reach the level of statistical significance. Interestingly, in mice treated intragastrically with citrate-coated AgNPs, the number of lung metastases was significantly lower, as compared to control mice (the mean number of metastases 18.89, 14.90, and 8.03 for control, AgNPs-PEG, and AgNPs-citrate, respectively). No effect of AgNPs treatment on the number of lung metastases was observed after intravenous administration (the mean number of metastases 12.44, 9.86, 12.88, 11.05, and 10.5 for control, AgNPs-PEG 1 mg/kg, AgNPs-PEG 5 mg/kg, AgNPs-citrate 1 mg/kg, and AgNPs-citrate 5 mg/kg, respectively). Surprisingly, inhibition of metastasis was not accompanied by changes in the expression of genes associated with epithelial-mesenchymal transition. Instead, changes in the expression of inflammation-related genes were observed. The presented results support the antitumor activity of AgNPs in vivo, but the effect was limited to the inhibition of metastasis. Moreover, our results clearly point to the importance of AgNPs coating and route of administration for its anticancer activity. Finally, our study supports the previous findings that antitumor AgNPs activity may depend on the activation of the immune system and not on the direct action of AgNPs on cancer cells.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Skeletal metastasis from carcinoma of the gall bladder : need for bone scintigraphy justified?
Autorzy:
Hira, Priya
Aswani, Yashant
Opis:
BACKGROUND: Carcinoma of the gall bladder has a guarded prognosis with predominant sites of involvement being liver and regional nodes. Osseous metastasis in carcinoma of the gall bladder is rare and hence bone scintigraphy does not form a part of the routine work-up for such patients. CASE REPORT: We describe two patients with carcinoma of the gall bladder with osteolytic metastasis (stage 4). Conservative treatment was planned but both of them succumbed to the illness. CONCLUSIONS: We thus highlight the importance of performing a bone scan or PET CT in cases of carcinoma of the gall bladder. Besides, our cases challenge Paget's seed - soil theory for sites of metastasis.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł

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