Temat: model 5A - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Beacons as the touchpoints on the customer journey
Autorzy:: Bajak, Maria
Tematy:: beacons
customer journey
consumer buying behavior
touchpoints
market communication
model 5A
beacon
zachowania zakupowe konsumentów
touchpointy
komunikacja rynkowa; Pokaż więcej
Wydawca:: Politechnika Śląska. Wydawnictwo Politechniki Śląskiej
Powiązania:: https://bibliotekanauki.pl/articles/27313548.pdf Link otwiera się w nowym oknie
Opis:: Purpose: The overriding goal of the presented considerations is to discuss beacons as consumer-brand touchpoints. In addition, the possibilities of using these sensors at various stages of the customer journey to implement the assumptions of the 5A model and build a lasting relationship with the buyer were indicated. Design/methodology/approach: In order to build a lasting relationship with the consumer, it is necessary to conduct multidimensional marketing communication based on numerous touchpoints. This interaction is assisted by mobile devices and many different technological solutions. One of them may be beacons, supporting consumer service at every stage of the customer journey. As part of the considerations, it was examined how the sensors can support marketing activities at individual stages of the customer journey. Findings: As part of the research, it was determined what role beacons can play at every stage of the customer journey, as well as their connections with promotion-mix elements. An attempt has been also made to indicate how these devices can create a holistic experience leading to buyer satisfaction and ultimately their loyalty. Research limitations/implications: The article contains a preliminary study. In the future it is planned to conduct additional quantitative and qualitative research. The study will help to perform a comprehensive analysis of the application being discussed. Practical implications: The article can help businesses to better realize the potential of beacons as a tool to support consumers during the shopping experience. It shows practical ways of using devices as part of individual promotional mix elements, which allows for their optimal use at all stages of the customer journey. Originality/value: Although the topic of beacons in commerce appears in academic publications, only a few of them relate these devices to the customer journey. This paper comprehensively deals with this topic and focuses on the relationship between sensors, the 5A model and the promotion mix tools.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Parametric studies and simulation of PSA process for oxygen production from air
Autorzy:: Beeyani, A.
Singh, K.
Vyas, R.
Kumar, S.
Tematy:: amplituda ciśnienia adsorpcji
model matematyczny
symulacja
produkcji tlenu
MATLAB
Zeolit5A
pressure swing adsorption
mathematical model
simulation
oxygen production
Zeolite 5A; Pokaż więcej
Wydawca:: Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Powiązania:: https://bibliotekanauki.pl/articles/779567.pdf Link otwiera się w nowym oknie
Opis:: A numerical simulation and parametric studies for the separation of air using 5A zeolite for the production of oxygen are presented for a basic two bed pressure swing adsorption (PSA) process. The simulation is based on an in-house program 'PSASOL' developed in MATLABŽ. The transient process of PSA has been described by a set of partial differential equations, which were solved using a finite difference method. Simulation results have been validated with the experimental data from literature. Based on the simulation results, an optimal set of operational parameter values has been obtained for the PSA bed. The values of the optimal parameters, viz. adsorption pressure, cycle time, feed rate, and product rate have been found to be 2.5 atm, 150 s, 15 cm3/s, and 2.55 cm3/s, respectively. For the optimal conditions, purity of 95.45% and recovery of 77.3% have been achieved. It has also been found that a longer tubular unit with the length to diameter (L/D) ratio of 10.5 is advantageous. The estimated pressure drop across the bed has been found to be negligible. Power consumption and productivity have also been computed.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Do AutoML-based QSAR models fulfill OECD principles for regulatory assessment? A 5-HT_1A receptor case
Autorzy:: Czub, Natalia
Pacławski, Adam
Szlęk, Jakub
Mendyk, Aleksander
Opis:: The drug discovery and development process requires a lot of time, financial, and workforce resources. Any reduction in these burdens might benefit all stakeholders in the healthcare domain, including patients, government, and companies. One of the critical stages in drug discovery is a selection of molecular structures with a strong affinity to a particular molecular target. The possible solution is the development of predictive models and their application in the screening process, but due to the complexity of the problem, simple and statistical models might not be sufficient for practical application. The manuscript presents the best-in-class predictive model for the serotonin 1A receptor affinity and its validation according to the Organization for Economic Co-operation and Development guidelines for regulatory purposes. The model was developed based on a database with close to 9500 molecules by using an automatic machine learning tool (AutoML). The model selection was conducted based on the Akaike information criterion value and 10-fold cross-validation routine, and later good predictive ability was confirmed with an additional external validation dataset with over 700 molecules. Moreover, the multi-start technique was applied to test if an automatic model development procedure results in reliable results.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 4.

Tytuł:: HBK-15, a multimodal compound, showed an anxiolytic-like effect in rats
Autorzy:: Lustyk, Klaudia
Wesołowska, Anna
Partyka, Anna
Marona, Henryk
Jastrzębska-Więsek, Magdalena
Sałaciak, Kinga
Jakubczyk, Magdalena
Pytka, Karolina
Opis:: Anxiety is a common mental disorder, and its prevalence has lately increased because of the COVID-19 pandemic. Unfortunately, the available anxiolytics are often ineffective, and most possess addictive potential. Thus, searching for novel compounds is essential. In our previous studies, we selected a multimodal compound, HBK-15, which showed a fast antidepressant-like effect in animal models of depression. HBK-15 demonstrated a high affinity for serotonin 5-HT1A receptors and moderate for 5-HT$_{7}$, dopamine D$_{2}$, and α1-adrenoceptors. Based on the receptor profile and preliminary studies, we aimed to investigate the anxiolytic potential of HBK-15 using the conditioned-response rat model of anxiety, i.e., the Vogel drinking test. We performed hot plate and free-drinking tests to exclude false positive results in the Vogel test. Using radioligand binding studies, we also investigated the affinity of the compound for the selected biological targets, which play a role in anxiety. Our experiments revealed that HBK-15 showed an anxiolytic-like effect in rats (5 mg/kg) without influencing the pain threshold or the amount of water consumed in the free-drinking test. Furthermore, the tested compound did not show a significant affinity for the selected biological targets, which suggests that its anxiolytic-like mechanism of action could be connected with the interaction with other receptors. This study indicates that multimodal compounds with a receptor profile similar to HBK-15 could be an attractive therapeutic option for patients with a generalized anxiety disorder. However, more studies are required to determine the exact mechanism of action of HBK-15 and its safety profile.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 5.

Tytuł:: The role of higher education institutions in shaping the intellectual capital in light of marketing innovation
Rola szkół wyższych w kształtowaniu kapitału intelektualnego w perspektywie marketingu innowacji
Autorzy:: Białoń, Lidia
Tematy:: 5I’s marketing
A-to-F model
Curriculum
Innovation
innovation marketing
intellectual capital
gospodarka innowacyjna
kapitał intelektualny
marketing 5I
marketing innowacji
model od A do F
programy nauczania; Pokaż więcej
Wydawca:: Sieć Badawcza Łukasiewicz - Instytut Lotnictwa
Powiązania:: https://bibliotekanauki.pl/articles/941571.pdf Link otwiera się w nowym oknie
Opis:: The systemic approach implied by marketing innovation requires professional shaping of the intellectual capital. Innovation marketing shall fulfill its role on the basis of 5 i’s principle. Fulfillment of those tasks requires specialists, thoroughly trained in marketing, management and in the theoretical foundations for innovative activity. The higher education institutions are responsible for preparing such specialists. The fundamental problems lie both in constructing adequate curricula and in training the instructors for using them in class. On the one hand, such program should derive from the logic of the processes of innovation; on the other it should draw from the rules of marketing and management. The necessary level and structure of the intellectual capital demands precise adaptation of such programs to consolidated actions within marketing innovation.
Podstawą działania marketingu innowacji są zasady nowoczesnego marketingu, zwłaszcza zasada 5 I, tj. identyfikacja, indywidualizacja, interakcja, integracja, integralność. Realizacji tych zadań mogą sprostać gruntownie przeszkoleni specjaliści, w zakresie marketingu, zarządzania i teoretycznych podstaw działalności innowacyjnej. Za ich przygotowanie są odpowiedzialne wyższe uczelnie. Podstawowym problemem w tym zakresie są odpowiednie programy nauczania oraz szkolenie kadry dydaktycznej dla ich realizacji. Programy te powinny wynikać z logiki procesów innowacyjnych ale też czerpać z ogólnych zasad marketingu i zarządzania. Dobrze zrealizowane zadania w tym zakresie przez szkoły wyższe szczególnie w zakresie przygotowania kadr menedżerskich dla zarządzania gospodarką innowacyjną, także dla marketingu innowacji może być doskonałym atutem ich przewagi konkurencyjnej na rynku edukacji.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Aktywność analgetyczna nowych ligandów receptora 5-HT1A w zwierzęcych modelach bólu neuropatycznego
The analgesic activity of the new 5-HT1A receptor ligands in animal models of neuropathic pain
Autorzy:: Dyląg, Monika
Opis:: Neuropathic pain is a type of pathological chronic pain and is initiated by the primary injury or dysfunction of nervous system. Recent studies have enabled a better comprehension of the mechanisms leading to the development of this kind of pain. However, effective treatment still remains a great challenge in medicine. Due to the fact, that neuropathic pain is highly resistant to commonly used treatment, there is still a need for searching for new compounds that could be more effective. 5-HT1A serotonergic receptor agonists bring a great hope for better treatment of neuropathic pain.The aim of this study was to determine the potential analgesic activity of two new phenylpiperazine derivatives, in animal models of neuropathic pain. These compounds are the 5-HT1A receptor agonists. To demonstrate the analgesic effectiveness of these compounds, von Frey test and cold water test were carried out. In these tests, mice with previously induced neuropathy were used. Neuropathy was obtained either by sciatic nerve ligation or single oxaliplatin administration.Tested compounds have shown a substantial and statistically significant analgesic activity in both neuropathic pain models (mechanical allodynia and cold allodynia model). Moreover, the contribution of 5-HT1A receptors in the analgesic activity mechanism of tested compounds was confirmed.
Ból neuropatyczny jest rodzajem patologicznego bólu przewlekłego i jest zainicjowany przez pierwotne uszkodzenie lub dysfunkcję układu nerwowego. Mimo, iż badania ostatnich lat przyniosły ze sobą znacznie lepsze zrozumienie mechanizmów prowadzących do rozwoju tego rodzaju bólu, skuteczna terapia wciąż stanowi ogromne wyzwanie dla współczesnej medycyny. Ze względu na wysoki stopień oporności bólu neuropatycznego na dotychczas poznane leczenie, nadal poszukuje się nowych związków, które mogłyby okazać się bardziej skuteczne w walce z tym bólem. Dużą nadzieję niosą ze sobą agoniści receptora serotoninergicznego 5-HT1A.Celem niniejszej pracy było oznaczenie potencjalnej aktywności przeciwbólowej dwóch nowych pochodnych fenylopiperazyny w zwierzęcych modelach bólu neuropatycznego. Związki te należą do agonistów receptora serotoninergicznego 5-HT1A. Testy behawioralne mające wykazać skuteczność analgetyczną badanych związków obejmowały test von Freya oraz test zimnej wody. Badania te zostały przeprowadzone na myszach, u których wyindukowano wcześniej neuropatię poprzez podwiązanie nerwu kulszowego bądź podanie oksaliplatyny.Badane związki wykazały się znaczącą i znamienną statystycznie aktywnością analgetyczną, w obu modelach bólu neuropatycznego (model mechanicznej allodyni i allodyni na zimno). Ponadto potwierdzono udział receptorów 5-HT1A w mechanizmie analgetycznego działania badanych związków.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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