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Wyświetlanie 1-10 z 58
Tytuł:
DNA – a molecule that transformed science. A short history of research
Autorzy:
Gabryelska, Marta M.
Szymański, Maciej
Barciszewski, Jan
Tematy:
DNA
molecular biology
genomics
genetics
Pokaż więcej
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Powiązania:
https://bibliotekanauki.pl/articles/703398.pdf  Link otwiera się w nowym oknie
Opis:
Deoxyribonucleic acid (DNA) was identified 140 years ago by a Swiss physician Friedrich Miescher. His discovery was fundamental for the development of biochemistry, genetics and molecular biology. Contemporary biology, biotechnology and medicine largely depends on our ability to analyze, synthesize and manipulate DNA. We present highlights of the history of DNA research from the very beginning to the sequencing of human genome.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
ELF3 as an important factor in carcinogenesis – a brief review of the recent studies
Autorzy:
Domańska, Julia
Poboży, Kamil
Kuryłek, Michał
Fudalej, Marta M.
Sobiborowicz, Aleksandra
Deptała, Andrzej
Badowska-Kozakiewicz, Anna M.
Tematy:
ELF3
carcinogenesis
molecular biology
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Wydawca:
Medical Education
Powiązania:
https://bibliotekanauki.pl/articles/1035652.pdf  Link otwiera się w nowym oknie
Opis:
Introduction and objective: E74-like transcription factor 3 (ELF3) is mainly expressed in epithelial tissue, being responsible for differentiation and regeneration. Furthermore, it plays a role in inflammation, remodeling, allergy regulation and apoptosis. Various studies on ELF3 conducted since 1997 have also proved its connection with carcinogenesis and metastasis. This review summarizes recent advances in understanding the role of ELF3 in the following cancers: ampullary, bladder, breast, gastric, hepatocellular, nasopharyngeal, thyroid, lung and ovarian ones. State of knowledge: There are still many unresolved and undiscovered issues regarding ELF3 mutations, however, based on research since 2016, a link to many signaling pathways important for carcinogenesis has been shown. There is no simple correlation between a specific ELF3 mutation and effect on cancer cells. In various types of cancers, ELF3 is associated with other pathways, and modifications exerted by silencing or amplifying its or associated genes, cause different effects in patient prediction. An example of the effect of ELF3 on tumor progression is achieved by negatively regulating the ZEB1 transcription factor responsible for metastasis. WNT, RAS, Akt, mTOR, HER2, Cyclin D, IRF6 are other ELF3-related factors that affects pathways crucial for tumorigenesis. Conclusions: Further research and attempts to use ELF3 in the treatment and prognosis of cancer appear to be beneficial.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Simulation of the electrophoresis of DNA by the method of cellular automata
Autorzy:
Krawczyk, Małgorzata
Kułakowski, Krzysztof
Tematy:
Biochemistry, molecular biology
Cellular automata
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Wydawca:
Polskie Towarzystwo Matematyczne
Powiązania:
https://bibliotekanauki.pl/articles/747601.pdf  Link otwiera się w nowym oknie
Opis:
.
The authors give the description of a new cellular automaton for simulating the electrophoresis of gel DNA. This automaton is deterministic, which corresponds to the well-known Monte Carlo rules holding for the electrophoresis at a low temperature and a high intensity electric field. The experimental results indicate that under such conditions the electrophoresis efficiency depends significantly on the string length.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bioengineering in cosmetology – the overview of present state and future prospects
Autorzy:
Betyna, Monika
Tematy:
engineering
innovation
molecular biology
techniques
technology
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Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Powiązania:
https://bibliotekanauki.pl/articles/1178917.pdf  Link otwiera się w nowym oknie
Opis:
Biological engineering, also referred to as bioengineering, is a branch of biotechnology focused on solving problems of life sciences with the use of the most modern technology, analytical and synthetic methodologies, including possibly lowest cost of the conducted analyses and procedures. Nowadays, bioengineering is in the lead in the scientific world. Unlike traditional engineering techniques, which apply mathematical and physical sciences to analysis processes and structures of biological systems, the biological engineering is capable of molecular analysis due to developing knowledge of molecular biology and progress in technology.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Molecular biology of sporadic vestibular schwannomas including genetic and epigenetic alterations
Autorzy:
Makuszewska, Maria
Litwiniuk-Kosmala, Małgorzata
Bartoszewicz, Robert
Niemczyk, Kazimierz
Tematy:
gene expression
merlin
microRNA
molecular biology
neuroblastoma
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Wydawca:
Index Copernicus International
Powiązania:
https://bibliotekanauki.pl/articles/1399235.pdf  Link otwiera się w nowym oknie
Opis:
Introduction: Vestibular schwannomas (VS) are benign tumors developing from the myelin-producing Schwann cells, which surround the vestibular branches of the auditory nerve. The vast majority occur sporadically and a small proportion are associated with neurofibromatosis type 2 (NF2). Most sVS are slow-growing neoplasms; however some have a cystic structure, show more rapid growth, cause more frequently paralysis of the facial nerve, and brainstem compression. The molecular hallmark of both sporadic and NF-2 associated VS is the inactivation of the tumor-suppressor gene NF2, also called merlin gene. Purpose: The paper presents the current knowledge on the molecular biology of VS, including: information on genetic and epigenetic aberrations, changes in gene expression and specific microRNA expression profiles.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Współczesna rewolucja naukowa na pograniczu fizyki i biologii
The Present Scientific Revolution on the Borderline between Physics and Biology
Autorzy:
Ślósarek, Genowefa
Tematy:
scientific revolution
molecular biology
biophysics
nanotechnology
single-molecule methods
system biology
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Wydawca:
Copernicus Center Press
Powiązania:
https://bibliotekanauki.pl/articles/690980.pdf  Link otwiera się w nowym oknie
Opis:
At the end of the 20th century, substantial changes in the paradigms of molecular physics and biology occurred. They have brought two new and entirely independent, fields of scientific research – nanotechnology and systems biology. Thanks to these disciplines, a new paradigm was born opening a new way of research in biology. It enables a holistic treatment of living organisms. As a consequence of these changes, an entirely new picture of the interface between physics and biology emerges.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Heat shock protein A2 is a novel extracellular vesicle-associated protein
Autorzy:
Mielańczyk, Łukasz
Abramowicz, Agata
Karnas, Elżbieta
Telka, Ewa
Adamiec-Organiściok, Małgorzata
Scieglinska, Dorota
Blamek, Sławomir
Kania, Daria
Sojka, Damian Robert
Opis:
70-kDa Heat Shock Proteins (HSPA/HSP70) are chaperones playing a central role in the proteostasis control mechanisms. Their basal expression can be highly elevated as an adaptive response to environmental and pathophysiological stress conditions. HSPA2, one of poorly characterised chaperones of the HSPA/HSP70 family, has recently emerged as epithelial cells differentiation-related factor. It is also commonly expressed in cancer cells, where its functional significance remains unclear. Previously, we have found that proteotoxic stress provokes a decrease in HSPA2 levels in cancer cells. In the present study we found that proteasome inhibition-related loss of HSPA2 from cancer cells neither is related to a block in the gene transcription nor does it relate to increased autophagy-mediated disposals of the protein. Proteotoxic stress stimulated extracellular release of HSPA2 in extracellular vesicles (EVs). Interestingly, EVs containing HSPA2 are also released by non-stressed cancer and normal cells. In human urinary EVs levels of HSPA2 were correlated with the levels of TSG101, one of the main EVs markers. We conclude that HSPA2 may constitute basic components of EVs. Nevertheless, its specific role in EVs and cell-to-cell communication requires further investigation.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Wyświetlanie 1-10 z 58

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