Temat: nausea - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: A quantitative analytical investigation on the oxycodone side effects listed in recent clinical trials
Autorzy:: Toussi, Alireza Ghassemi
Toosi, Farshad Ghassemi
Tematy:: oxycodone
nausea
vomiting
itching
confusion; Pokaż więcej
Wydawca:: Gdański Uniwersytet Medyczny
Powiązania:: https://bibliotekanauki.pl/articles/2203242.pdf Link otwiera się w nowym oknie
Opis:: Background: Oxycodone is a semi-synthetic narcotic analgesic medication with numerous side eefcts. Patients who use oxycodone may have one or more side eefcts depending on their clinical status and/or other factors. Our aim was to analyze clinical trials for any potential paetrn related to the side eefcts of oxycodone. Methods: We searched the ClinicalTrials.gov database for clinical studies conducted around the world regarding oxycodone. A number of general data analytic and text manipulation techniques were used in the Python programming language. Results: We analyzed 842 clinical trials involving oxycodone. Our results suggest that the researchers focused on oxycodone's typical side eefcts (e.g. vomiting), as opposed to the less evident and/or long-term side eefcts e.g. depression, confusion and constipation. Conclusions: The adverse eefcts of oxycodone most commonly reported in the clinical trials are nausea, vomiting and depression. Despite the clinical use of oxycodone in all the age groups (including infants), very few of the publicly-available clinical trials included participants < 18 years of age. Toussi AG, Toosi FG. A quantitative analytical investigation on the oxycodone side eefcts listed in recent clinical trials. Eur J Transl Clin Med. 2023;6(1):58-63.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: A quantitative analytical investigation on the oxycodone side effects listed in recent clinical trials
Autorzy:: Toosi, Farshad Ghassemi
Toussi, Alireza Ghassemi
Wydawca:: Medical University of Gdańsk
Cytata wydawnicza:: Toussi AG, Toosi FG. A quantitative analytical investigation on the oxycodone side effects listed in recent clinical trials. Eur J Transl Clin Med. 2023;6(1):58-63. DOI:10.31373/ejtcm/163415
Opis:: Background: Oxycodone is a semi-synthetic narcotic analgesic medication with numerous side effects. Patients who use oxycodone may have one or more side effects depending on their clinical status and/or other factors. Our aim was to analyze clinical trials for any potential pattern related to the side effects of oxycodone. Methods: We searched the ClinicalTrials.gov database for clinical studies conducted around the world regarding oxycodone. A number of general data analytic and text manipulation techniques were used in the Python programming language. Results: We analyzed 842 clinical trials involving oxycodone. Our results suggest that the researchers focused on oxycodone’s typical side effects (e.g. vomiting), as opposed to the less evident and/or long-term side effects e.g. depression, confusion and constipation. Conclusions: The adverse effects of oxycodone most commonly reported in the clinical trials are nausea, vomiting and depression. Despite the clinical use of oxycodone in all the age groups (including infants), very few of the publicly-available clinical trials included participants < 18 years of age.
Dostawca treści:: Repozytorium Centrum Otwartej Nauki

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Skocz do pozycji: 3.

Tytuł:: CANNABINOIDS AS ANTIEMETICS: A SHORT REVIEW
Autorzy:: Mikołajczak, Przemysław Ł.
Calavia Liano, Hugo
Zakowicz, Przemysław
Tematy:: cancer
chemotherapy
nausea
vomiting
Emesis; Pokaż więcej
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Powiązania:: https://bibliotekanauki.pl/articles/895448.pdf Link otwiera się w nowym oknie
Opis:: Chemotherapy Induced Nausea and Vomiting (CINV) remains one of the most frequent adverse effects of cancer chemotherapy, often leading to patient non-adherence to the prescribed chemotherapeutic regime, as well as several associated complications. Current antiemetic therapy has been reported to provide relief of CINV in 75%-80% of patients, still leaving margin for improvement. This makes the development and study of novel antiemetics, especially those providing relief of both early and late phases of CINV, a matter of prime importance. The purpose of this review is to illustrate the mechanism of action of cannabinoid substances and provide a general view into their current use as antiemetic drugs in clinical practice. Several research articles pertaining the subject were compiled and studied. This review presents the information thereby obtained. It is concluded that cannabinoids possess value as antiemetic drugs, along with certain properties that set them apart from other classes of antiemetic substances.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: A nursing perspective of nutrition in cancer patients undergoing chemotherapy
Autorzy:: Lavdaniti, M.
Tematy:: Nutrition
chemotherapy
cancer
nausea-vomiting
diarrhea
constipation; Pokaż więcej
Wydawca:: Uniwersytet Medyczny w Białymstoku
Powiązania:: https://bibliotekanauki.pl/articles/1916646.pdf Link otwiera się w nowym oknie
Opis:: Purpose: To present of an appropriate diet consists in cancer patients undergoing chemotherapy. Materials and methods: A search was made in the Pubmed and Scopus databases for reports on nutrition and chemotherapy in cancer patients. There were used the following key words: nutrition, cancer, chemotherapy and the combination of them. Results: Nutritional problems of patients are caused by the same disease, the antitumor therapy and the patient's response to the diagnosis and treatment. Symptoms such as anorexia, changes in taste, nausea - vomiting, diarrhea, stomatitis and constipation are common side effects of chemotherapy and can lead to inadequate food intake and consequently, malnutrition. There are many appropriate nursing interventions that alleviate the above symptoms. Conclusions: Nurse plays an important role in the care of patients who have been feeding problems receiving chemotherapy. Nutritional interventions are individualized and should be started immediately and incorporated into the care plan in order to be successful. In order this to be achieved; all patients should be assessed for nutritional problems and weight loss before starting treatment and after starting regularly.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Comparison of granisetron and palonosetron for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgery: a prospective randomised study
Autorzy:: Singh, Priyanka
Kachru, Nisha
Yadav, Nidhi
Singhal, Shubhi
Yadav, Rupesh
Tematy:: Granisetron
palonosetron
PONV
laparoscopic surgery
nausea
vomiting; Pokaż więcej
Wydawca:: Towarzystwo Pomocy Doraźnej
Powiązania:: https://bibliotekanauki.pl/articles/48867290.pdf Link otwiera się w nowym oknie
Opis:: INTRODUCTION: Postoperative nausea and vomiting (PONV), a common and uncomfortable consequence of anaesthesia and surgery, can lead to dehydration, alkalosis, aspiration, and psychological distress, including a reluctance to undergo future surgical procedures. The aim of the study was to compare the effect of Granisetron and Palonosetron on the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgery under general anaesthesia. MATERIALS AND METHODS: In this randomised prospective study, after a full preoperative evaluation and investigation, patients meeting the inclusion criteria were taken for the study. 80 patients were selected and randomly divided into two groups. Group G received 40 mcg/kg of granisetron and group P was administered palonosetron 1 mcg/kg before induction of anesthesia. The patients were monitored in the postoperative period and PONV scores were observed at 0-2, 4-6, 6-12, and 12-24 hours postoperatively. Rescue antiemetic, in the form of Dexamethasone 4 mg IV, was administered with PONV score <1. RESULTS: There were no statistically significant differences between the two groups with respect to the classification of ASA, the sex distribution, age, BMI or the duration of anaesthesia, making the two groups comparable. PONV scores were comparable between the two groups during 0 to 2 hours and 2 to 6 hours postoperatively (p value>0.05). During the 6- to 12-hour interval and the 12- to 24-hour interval, PONV scores were significantly lower in patients in Group P (p-value 0.022). There was no statistically significant difference between the antiemetic rescue requirement between the group G and group P (p-value 0.152). CONCLUSIONS: This study concludes that both granisetron and palonosetron are effective in controlling PONV in the immediate postoperative period, but palonosetron is superior to granisetron in preventing PONV beyond 6 hours.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Comparison of granisetron and palonosetron for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgery: a prospective randomised study.
Autorzy:: Kachru, Nisha
Singhal, Shubhi
Singh, Priyanka
Yadav, Rupesh
Yadav, Nidhi
Wydawca:: Towarzystwo Pomocy Doraźnej
Cytata wydawnicza:: Singh P, Kachru N, Yadav N, Singhal S, Yadav R. Comparison of granisetron and palonosetron for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgery: a prospective randomised study. Crit. Care Innov. 2024; 7(3): 1-10.
Opis:: INTRODUCTION: Postoperative nausea and vomiting (PONV), a common and uncomfortable consequence of anaesthesia and surgery, can lead to dehydration, alkalosis, aspiration, and psychological distress, including a reluctance to undergo future surgical procedures. The aim of the study was to compare the effect of Granisetron and Palonosetron on the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgery under general anaesthesia. MATERIALS AND METHODS: In this randomised prospective study, after a full preoperative evaluation and investigation, patients meeting the inclusion criteria were taken for the study. 80 patients were selected and randomly divided into two groups. Group G received 40 mcg/kg of granisetron and group P was administered palonosetron 1 mcg/kg before induction of anesthesia. The patients were monitored in the postoperative period and PONV scores were observed at 0-2, 4-6, 6-12, and 12-24 hours postoperatively. Rescue antiemetic, in the form of Dexamethasone 4 mg IV, was administered with PONV score <1. RESULTS: There were no statistically significant differences between the two groups with respect to the classification of ASA, the sex distribution, age, BMI or the duration of anaesthesia, making the two groups comparable. PONV scores were comparable between the two groups during 0 to 2 hours and 2 to 6 hours postoperatively (p value>0.05). During the 6- to 12-hour interval and the 12- to 24-hour interval, PONV scores were significantly lower in patients in Group P (p-value 0.022). There was no statistically significant difference between the antiemetic rescue requirement between the group G and group P (p-value 0.152). CONCLUSIONS: This study concludes that both granisetron and palonosetron are effective in controlling PONV in the immediate postoperative period, but palonosetron is superior to granisetron in preventing PONV beyond 6 hours.
Dostawca treści:: Repozytorium Centrum Otwartej Nauki

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Skocz do pozycji: 7.

Tytuł:: Ginger as a non-pharmacological prevention of postoperative nausea and vomiting (PONV): a review
Autorzy:: Oklińska, Joanna
Gniado, Weronika
Kazimierski, Bartłomiej
Jadczak, Klaudia
Mądry, Dawid Szymon
Skóra, Michał
Rusak, Aleksandra
Krych, Gabriela
Wydawca:: Gdański Uniwersytet Medyczny
Cytata wydawnicza:: Gniado W., Mądry D. S., Krych G., Rusak A., Oklińska J., Skóra M., Jadczak K., Kazimierski B. Ginger as a non-pharmacological prevention of postoperative nausea and vomiting (PONV): a review Eur J Transl Clin Med 2024;7(2):92-99. https://doi.org/10.31373/ejtcm/196003
Opis:: Postoperative nausea and vomiting (PONV) are significant clinical problems associated with patients’ unpleasant experiences and potential complications such as dehydration and electrolyte imbalances. In the search for effective methods of alleviating PONV, increasing attention is paid to the therapeutic properties of ginger. This review aims to summarize the current state of knowledge regarding the effect of ginger on reducing PONV. Analysis of conducted clinical studies suggests that ginger may be an effective agent in alleviating PONV after surgeries. Many of these studies indicate the beneficial effects of ginger, particularly when used in combination with conventional antiemetic drugs. Due to differences in methodology and inconclusive results in some studies, more research is needed to confirm these results and establish optimal doses and routes of administering ginger in clinical practice.
Dostawca treści:: Repozytorium Centrum Otwartej Nauki

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Skocz do pozycji: 8.

Tytuł:: Uwikłani w słowa - dylematy językowej podmiotowości bohaterów w utworach J.-P. Sartrea
„Entangled in words” – the dilemmas of linguistic identity of characters in J.-P. Sartre’s works
Autorzy:: Sokół, Dorota
Opis:: Pracę poświęcam zagadnieniu podmiotowości bohaterów w utworach Jean-Paula Sartre’a, w kontekście jej ugruntowania w języku. Analizie poddaję dwie powieści, wyzna¬czające ramę chronologiczną w jego twórczości fikcyjnej: debiutanckie Mdłości (1938) oraz ostatnią jego powieść, o charakterze autobiograficznym – Słowa (1964). Zdecydowałam się na analizę tych właśnie tekstów, by na ich przykładzie poruszyć zagadnienia, które Sartre’a interesowały przez cały okres jego aktywności literackiej. Celem było zaobserwować, jak tematyka podmiotowości, egzystencji człowieka w świecie w epoce modernizmu, ewoluowała w dziełach Sartre’a, jaki związek mają Słowa z wczesną próbą literacką, w której Sartre dopiero rozwijał swoje przekonania filozoficzne, ubierając je w formę powieściową. Ze względu na to, że obydwie powieści są mocno zakorzenione w charakteryzujących epokę modernizmu prądach myślowych, w pierwszym rozdziale pracy nakreślam kontekst, w którym będę następnie analizowała powieści. „Modernizm” traktuję raczej w szerokim ujęciu, jako formację literacką, światopoglądową czy artystyczną, która przypadała na czas od końca XIX wieku, do lat sześćdziesiątych wieku XX. Kolejne dwie części poświęcam analizie tekstów, ukazując paradoksalną, niejednoznaczną rolę języka dla podmiotowości bohaterów.
The subject of my work is the notion of subjectivity in Jean-Paul Sartre’s works, in context of its linguistic ground. I will examine two novels which delimit a chronological phrame for his fiction: ‘Nausea’ (1938) – his first performance and ‘The Words’ (1964), the last, autobiographical novel. I have chosen these two works to raise issues that have been intriguing Sartre through all the period of his literary creativity. The aim is to observe an evaluation of the identity’s notion, notion of human existence in the world, in modernistic way in Sartre’s works. Moreover – to find connection between ‘The Words’ and his début, where Sartre was only starting to develop his philosophical beliefs and so why he has chosen the form of novel. Because both of them are deeply related with thought of the era of modernism, in the first chapter I will give a context that will be useful for my future recognitions. By ‘modernism’ I understand here a broad literal, artistic and philosophical formation that has started in the end of 19th century and was still alive till sixties in XXth century. In the next two chapters I will examine two works of Sartre, to show a paradoxical, ambiguous role of language for the character’s identity.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 9.

Tytuł:: The role of selected variables in the diagnosis of cervical derangement syndromes
Rola wybranych zmiennych w diagnostyce szyjnych zespołów zaburzeń strukturalnych
Autorzy:: Frańczuk, Bogusław
Szpitalak, Malwina
Ridan, Tomasz
Guzy, Grażyna
Opis:: Background. The study analyzed correlations between selected variables in cervical derangement syndromes. Material and methods. We analyzed data from 63 patients regarding pain (VAS, McGill Pain Question naire), mobility (CROM goniometer), dizziness, nausea, the duration of the current episode, and the number of previous episodes (history). Student’s t and chi2 tests and Pearson’s r correlation were used. Results. Overall pain intensity correlated positively with the indexes of the McGill Pain Questionnaire, the duration of the current episode, intensity of the proximal and distal symptoms and negatively with protraction or extension. Headache correlated positively with neck pain and negatively with retraction. Neck pain cor related negatively with multiple cervical movements and positively with intensity of the distal symptoms. A po sitive relationship between shoulder and upper limb pain was observed. Patients with higher overall pain inten sity or lower shoulder pain intensity experienced dizziness more often. The duration of the current episode cor re lated positively with the number of previous episodes, the frequency of nausea, limited extension and limited protraction. Nausea coexisted with dizziness and reduced protraction. The degree of flexion restriction corre lated positively with the number of previous episodes. Conclusions. 1. Overall and proximal pain intensity, mobility of the cervical spine, the duration of the current episode and dizziness are useful in diagnosis of cervical derangement syndromes. 2. Intensity of the distal symptoms, the number of previous episodes and nausea should be particularly monitored.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 10.

Tytuł:: Development of an EORTC item bank for computer-adaptive testing of nausea and vomiting
Autorzy:: Velikova, Galina
Kemmler, Georg
Holzner, Bernhard
Püsküllüoglu, Mirosława
Young, Teresa
Groenvold, Mogens
Tomaszewska, Iwona
Petersen, Morten Aa
Opis:: Objectives: Nausea and vomiting (NV) remain common cancer symptoms and frequent side effects of anticancer therapies despite available antiemetics. They can lead to treatment disruption and discontinuation. NV is an important patient reported outcome in oncology. This study aimed to build an item bank for computer-adaptive testing (CAT) based on NV questions in the European Organisation for Research for Treatment of Cancer, Quality of Life for Cancer Patients (EORTC QLQ-C30) questionnaire and complete the first three phases of development as described in the EORTC Quality of Life Group guidelines. Data Sources: The development followed a standard procedure. The three phases include conceptualization and literature search (phase 1); item classification, selection, formulation and rating, and expert evaluations (phase 2); and patient pretesting (phase 3). The literature search resulted in a preliminary list of 115 items. Following classification, formulation, and rating, 21 candidate items adhered to the QLQ-C30 format. Evaluation by experts (n = 11) from five countries and patients (n = 31) pretesting in Denmark, Poland, and the UK lead to a final list of 20 items.Conclusion: The selection, development, and refining of NV items have been described. The nature of this testing ensures an initial CAT item bank that after field testing (phase 4) and psychometric analysis is expected to provide a precise and efficient NV measurement while still being comparable to the original QLQ-C30 scale.Implications for Nursing Practice: Access to reliable tools that facilitate NV comprehensive assessment is an important issue for nurses caring for patients with cancer. This CAT item bank is meant to support clinical decisions when all phases of testing are completed.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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