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    Wyświetlanie 1-7 z 7
    Tytuł:
    Immunohistochemical study of expression of immunoglobulins in canine B-cell lymphomas
    Autorzy:
    Sokolowska, J.
    Micun, J.
    Zabielska, K.
    Malicka, E.
    Lechowski, R.
    Tematy:
    immunohistochemistry
    expression
    immunoglobulin
    dog
    B cell
    lymphoma
    tumour
    neoplastic cell
    immunoglobulin light chain
    cancer
    Pokaż więcej
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Powiązania:
    https://bibliotekanauki.pl/articles/31685.pdf  Link otwiera się w nowym oknie
    Opis:
    Nineteen canine lymphomas were included in this study. Tumors were classified according to the updated Kiel classification adapted for canine lymphomas by Fournel-Fleury et al. Immunoglobulin light chains (κ and λ) and IgM and IgG expression were determined by immunohistochemical method. In all examined cases neoplastic cells were positive for one of the immunoglobulin light chains. Expression of λ light chains and κ light chains was observed in 18/19 and 1/19 tumors, respectively. In the majority of neoplastic cells in each examined specimen this reaction had a membranous pattern (sκ/sλ). In all examined cases the presence of immunoglobulin light chains was also observed in the cytoplasm of some neoplastic cells (cκ/cλ). These cells were usally rare and never constituted a dominant population. The expression of immunoglobulin was found in 13/19 cases. Most lymphomas were sIgM positive (11/13 cases). In one case expression of IgG was found, and in another lymphoma two populations of neoplastic cells with different expression of examined immunoglobulins (cells with IgM+ and IgG+ phenotypes) were observed. The reaction also had a membranous pattern. The cells containing cytoplasmic immunoglobulins were rare, and in most cases were of the same type as the surface immunoglobulins. Our study has confirmed that canine lymphomas are a monoclonal proliferation of B-cells usually expressing immunoglobulin λ light chains and that the vast majority of tumors deriving from B-cells express IgM. Our study also indicates a possibility of occurence of biclonal lymphomas in canine species.
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A clinicopathological study of nasal and paranasal sinus tumours
    Autorzy:
    Joshi, Ankita
    Behera, Subrat
    Malik, Junaid
    Tematy:
    histopathology
    nasal obstruction
    neoplastic lesion
    squamous cell carcinom
    Pokaż więcej
    Wydawca:
    Index Copernicus International
    Powiązania:
    https://bibliotekanauki.pl/articles/1398946.pdf  Link otwiera się w nowym oknie
    Opis:
    Introduction: A variety of benign and malignant tumours involving the nasal cavity and paranasal sinuses (PNS) are commonly encountered in clinical practice. The presenting features and symptomatology of all sinonasal masses are similar. It is impossible to determine clinically what pathology lies underneath. So a detailed history, clinical examination, proper imaging, and thorough histopathologic evaluation are essential to reach a diagnosis. Objectives The purpose of this study was to classify various types of Benign and malignant lesions presenting as nasal and paranasal mass and characterize their clinico-pathological profile in a tertiary care center. Materials and Methods: This was a prospective study where 120 cases of nasal and paranasal masses were included over a period of 24 months (sep 2013-sep 2015) Clinico-pathological study was carried out in these cases. A provisional diagnosis was made after clinical assessment and radiologic investigations, but final diagnosis was made after histopathologic examination. Results: The number of benign lesions were more than the malignant lesion, 66.66% versus 33.33% respectively. All age groups were involved and the mean age of presentation was benign tumours 29.5 years and malignant tumours 50.25 years. Male to Female ratio was 3:1 for benign tumours and 1.7:1 for malignant tumours. In our study, among benign lesions the occurrence of Angiofibroma was highest seen in 37.5% cases. In malignant lesions, Squamous cell carcinoma was most common seen in 67.5% cases. Carcinoma nasal cavity was the commonest malignant lesion seen in 70% cases. Nasal obstruction was the most common (91.6%) presenting complaint followed by intermittent epistaxis (69.16%) and nasal discharge (58.3%). Conclusion: We concluded that for proper evaluation of a sinonasal mass, clinical, radiologic, and histopathologic evaluation should be carried out conjointly in all the cases. Histopathology always gives a confirmatory diagnosis but in few cases immuno-histocytochemistry becomes the ultimate diagnostic technique for correct and timely intervention.
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Endovascular embolization of renal cell carcinoma in a patient with solitary kidney
    Autorzy:
    Sojka, Michał
    Kuklik, Ewa
    Szczerbo-Trojanowska, Małgorzata
    Światłowski, Łukasz
    Opis:
    Background: Kidney tumors account for about 3% of tumors in adults. The primary therapy of renal cancer is the surgical removal. Traditionally, and also modern procedures are performed to remove the kidneys, especially when the tumor involves the entire kidney. In the cases of unresectable tumors embolization is used as a palliative procedure. Case Report: The aim of this study is to present the case of endovascular treatment of renal cell carcinoma in patient with solitary kidney. 77-years old patient had an ultrasound examination because of the pain in left lumbar region. MRI confirmed the presence of tumor size 29×45 mm in the left kidney. The right kidney had been removed eight years earlier because of clear cell carcinoma. Histopathological diagnosis was renal clear cell carinoma. The patient did not consent to surgical treatment. Tumor embolization was proceeded as a minimally invasive procedure. Pathological tumor vessels were closed using particles filling the entire vascular tumor. Next, the blood vessels supplying the tumor were closed using a mixture of lipiodolu and glubranu. Control angiographiy of the left renal artery confirmed the effective closure of all vascular pathology. In a recent ultrasound examination which was done 15 months after surgery no evidence of vascular pathology was found. Conclusions: Embolization of kidney cancer in particular cases may be an alternative way of treatment and give a good result in the form of stopping the growth of the tumor with simultaneous retaining the remaining parenchyma and renal function.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
      Wyświetlanie 1-7 z 7

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