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    Wyświetlanie 1-9 z 9
    Tytuł:
    pH Profile of cytochrome c-catalyzed tyrosine nitration
    Autorzy:
    Kambayashi, Yasuhiro
    Hitomi, Yoshiaki
    Kodama, Norio
    Kubo, Masayuki
    Okuda, Junna
    Takemoto, Kei
    Shibamori, Masafumi
    Takigawa, Tomoko
    Ogino, Keiki
    Tematy:
    pseudo-peroxidase
    pH
    cytochrome c
    nitrite
    nitrotyrosine
    Pokaż więcej
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Powiązania:
    https://bibliotekanauki.pl/articles/1041220.pdf  Link otwiera się w nowym oknie
    Opis:
    In the present study, we investigated how cytochrome c catalyzed the nitration of tyrosine at various pHs. The cytochrome c-catalyzed nitration of tyrosine occurred in proportion to the concentration of hydrogen peroxide, nitrite or cytochrome c. Thecytochromec-catalyzed nitration of tyrosine was inhibited by catalase, sodium azide, cystein, and uric acid. These results show that the cytochrome c-catalyzednitrotyrosine formation was due to peroxidase activity. The rate constant between cytochrome c and hydrogen peroxide within the pH range of 3 - 8 was the largest at pH 6 (37°C). The amount of nitrotyrosine formed was the greatest at pH 5. At pH 3, onlycytochromec-independent nitration of tyrosine occurred in the presence of nitrite. At this pH, the UV as well as visible spectrum of cytochrome c was changed by nitrite, even in the presence of hydrogen peroxide, probably via the formation of a heme iron - nitric oxide complex. Due to this change, the peroxidase activity of cytochrome c was lost.
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Oxidative and nitrosative stress in patients with meningitis
    Autorzy:
    Namiduru, Emine Siber
    Namiduru, Mustafa
    Karaoğlan, İlkay
    Koçak, Kübra
    Tematy:
    bacterial meningitis
    oxidative stress
    nitrotyrosine
    tuberculous meningitis
    viral menengitis
    Pokaż więcej
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Powiązania:
    https://bibliotekanauki.pl/articles/2049160.pdf  Link otwiera się w nowym oknie
    Opis:
    Introduction and aim. Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord, known as the meninges. In this study, oxidative and nitrosative stress were evaluated in cerebrospinal fluid (CSF) and blood samples that were taken from patients with meningitis. Our goal was to identify a fast and a reliable biomarker using these parameters in order to the early diagnose of bacterial meningitis. Material and methods. In this study, 37 bacterial meningitis, 30 tuberculous meningitis and 30 viral meningitis cases were included. Serum/CSF total oxidant status (TOS) and total antioxidant status (TAS) were measured by the Erel method. Nitrotyrosine concentrations were quantified by using ELISA in both serum and CSF. Results. Serum nitrotyrosine, CSF TAS and TOS levels were not significantly different in three groups (p>0.05). CSF nitrotyrosine levels were significantly higher in bacterial meningitis than tuberculous meningitis group (p<0.05). Viral meningitis patients had higher serum TOS and TAS concentrations than tuberculous meningitis group (p<0.05). Conclusion. As a result, we can say that the oxidative and nitrosative stress markers studied are not a rapid and reliable biomarker in bacterial meningitis’s diagnosis.
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Nadtlenoazotyn - silny biologiczny utleniacz
    Peroxynitrite a strong biological oxidant
    Autorzy:
    Bijak, M.
    Ponczek, M. B.
    Saluk, J.
    Chabielska, M.
    Stępniak, J.
    Nowak, P.
    Tematy:
    nadtlenoazotyn
    stres oksydacyjny
    3-nitrotyrozyna
    peroxynitrite
    oxidative stress
    3-nitrotyrosine
    Pokaż więcej
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Powiązania:
    https://bibliotekanauki.pl/articles/172573.pdf  Link otwiera się w nowym oknie
    Opis:
    As demonstrated in recent years, one of the major factors of oxidative stress, generated in the circulatory system, in both acute and chronic pathological conditions, is peroxynitrite (ONOO –) [4]. Peroxynitrite is a strong biological oxidant and nitrating compound, generated in vivo from a rapid reaction of two relatively less reactive, but commonly found, of free radicals: nitrogen monoxide (NO ) and superoxide (O2–) [8]. This reaction occurs spontaneously and is not catalyzed by any enzyme. A fundamental reaction of ONOO – in biological systems is its fast reaction with carbon dioxide (k = 5,7 ź 104 M–1 s–1) and yields a short-lived intermediate, nitrosoperoxycarbonate (ONOOCO 2 –), which homolyzes leads to the formation of carbonate (CO 3–) and nitrogen dioxide (NO 2) radicals (yield ~35%) [29, 30] (Fig. 1), which are one-electron oxidants. ONOO – is responsible for oxidative modifications in a wide variety of biomolecules and is capable to induce of nitrative changes in sulfur and aromatic amino acids, especially 3-nitrotyrosine and dityrosine formation [17] (Fig. 2). This article describes the formation, reactivity and biological action of peroxynitrite.
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of Medicago sativa Mhb1gene expression on defense response of Arabidopsis thaliana plants
    Autorzy:
    Maassen, Anna
    Hennig, Jacek
    Tematy:
    Arabidopsis thaliana
    pathogen infection
    nitrotyrosine
    nitric oxide
    peroxidase activity
    non-symbiotic hemoglobin
    Pokaż więcej
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Powiązania:
    https://bibliotekanauki.pl/articles/1039900.pdf  Link otwiera się w nowym oknie
    Opis:
    Besides the previously described nitric oxide-detoxification activity we identified new features of class-1 non-symbiotic hemoglobin from Medicago sativa (Mhb1). Under in vitro conditions, using peroxidase in-gel activity assay, the Mhb1 protein was shown to possess also peroxidase-like activity. Due to this activity, in the presence of nitrite and hydrogen peroxide, the protein can mediate autonitration and nitration of other proteins at tyrosine residues, as revealed by tandem mass spectrometry and immune assay approaches. Mhb1 through its multifunctional activities can affect different components of signal transduction cascades operating during plant response to infections. This influence is manifested by Mhb1-mediated selective up-regulation of expression of certain pathogen inducible genes in Pseudomonas syringae infected Arabidopsis thaliana plants which overproduce Mhb1, as revealed by reverse transcription-quantitative real-time PCR analysis. Changes in expression level of these genes can influence such processes as synthesis of secondary metabolites, protein degradation and biosynthesis of ethylene. They can also result in alteration of pathogen-induced defense response of Mhb1 transgenic plants.
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Peroxynitrite mediated linoleic acid oxidation and tyrosine nitration in the presence of synthetic neuromelanins.
    Autorzy:
    Stępień, Krystyna
    Wilczok, Adam
    Zajdel, Alicja
    Dzierżęga-Lęcznar, Anna
    Wilczok, Tadeusz
    Tematy:
    3-nitrotyrosine
    DA/CysDA-copolymers
    peroxidation
    peroxynitrite
    CysDA-melanin
    DA-melanin
    nitration
    linoleic acid
    neuromelanin
    Pokaż więcej
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Powiązania:
    https://bibliotekanauki.pl/articles/1044213.pdf  Link otwiera się w nowym oknie
    Opis:
    Peroxynitrite-mediated linoleic acid oxidation and tyrosine nitration were analysed in the presence of synthetic model neuromelanins: dopamine (DA) -melanin, cysteinyldopamine (CysDA) -melanin and various DA/CysDA copolymers. The presence of melanin significantly decreased the amount of 3-nitrotyrosine formed. This inhibitory effect depended on the type and concentration of melanin polymer. It was found that incorporation of CysDA-derived units into melanin attenuated its protective effect on tyrosine nitration induced by peroxynitrite. In the presence of bicarbonate, the melanins also inhibited 3-nitrotyrosine formation in a concentration dependent manner, although the extent of inhibition was lower than in the absence of bicarbonate. The tested melanins inhibited peroxynitrite-induced formation of linoleic acid hydroperoxides, both in the absence and in the presence of bicarbonate. In the presence of bicarbonate, among the oxidation products appeared 4-hydroxynonenal (HNE). CysDA-melanin inhibited the formation of HNE, while DA-melanin did not affect the aldehyde level. The results of the presented study suggest that neuromelanin can act as a natural scavenger of peroxynitrite.
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of Finnish sauna treatments on the concentrations of nitric oxide, 3-nitrotyrosine and selected markers of oxidative status in training and non-training men
    Autorzy:
    Gryka, Dorota
    Pilch, Wanda
    Czerwińska-Ledwig, Olga
    Piotrowska, Anna
    Klocek, Ewa
    Bukova, Alena
    Tematy:
    Oxidative stress
    nitric oxide
    3-nitrotyrosine
    nitrosative stress
    Finnish sauna
    training and non-training men
    Pokaż więcej
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Powiązania:
    https://bibliotekanauki.pl/articles/2116648.pdf  Link otwiera się w nowym oknie
    Opis:
    ObjectivesThe aim of the study was to evaluate the effects of repeated Finnish sauna baths on the concentrations of nitric oxide metabolites (NOx) and 3-nitrotyrosine in relation to pro-oxidative and antioxidative status in young males with different physical activity levels.Material and MethodsThe study was performed on healthy males (aged 20–25 years), representing the training (T, N = 10) and non-training groups (NT, N = 10). The protocol included a series of 10 sauna baths during 3 weeks. One bath consisted of three 15-min sessions, with 2 min recovery. Before the first and the 10th treatment, measurements of body composition, blood pressure, rectal temperature, and plasma concentrations of the total pro-oxidative and antioxidative status, 3-nitrotyrosine and NOx were performed.ResultsA significant increase in physiological parameters during sauna treatments, as well as a significant decrease in the total antioxidative status before the 10th bath, were observed in both groups. The series of sauna baths caused a significant increase in the total antioxidative status in the T group, and a decrease in the total oxidative status in the NT group. A significant decrease in 3-nitrotyrosine in both groups before the last treatment, and also in the T group after the last treatment, was noted. In both groups, a significant increase in NOx concentrations was observed after the first bath.ConclusionsA series of sauna baths contributes to the improvement in the prooxidative/antioxidative balance. The increased production of nitric oxide may lead to a better vascular relaxation and blood flow.
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Biomarkery wykorzystywane w ocenie oksydacyjnych uszkodzeń białek
    Biomarkers of proteins oxidative damage
    Autorzy:
    Ognik, Katarzyna
    Cholewińska, Ewelina
    Tematy:
    3-nitrotyrosine
    advanced oxidation protein products
    biomarker
    oxidative stress
    protein
    protein carbonyl
    białko
    3-nitrotyrozyna
    pochodne karbonylowe
    stres oksydacyjny
    zaawansowane produkty utleniania białek
    Pokaż więcej
    Wydawca:
    Polskie Towarzystwo Przyrodników im. Kopernika
    Powiązania:
    https://bibliotekanauki.pl/articles/1033871.pdf  Link otwiera się w nowym oknie
    Opis:
    Przewaga procesów prooksydacyjnych w organizmie skutkuje wystąpieniem stresu oksydacyjnego objawiającego się m.in. utlenianiem białek. Bezpośrednia analiza ilości reaktywnych form tlenu i azotu jest zadaniem bardzo trudnym, dlatego w ocenie nasilenia stresu oksydacyjnego częściej wykorzystuje się markery uszkodzeń, powstające w wyniku reakcji wolnych rodników z białkami. Są one o wiele trwalsze, a przez to łatwiejsze do analizy. Wśród najważniejszych biomarkerów oksydacyjnych uszkodzeń białek wyróżnia się pochodne karbonylowe, 3-nitrotyrozynę, S-nitrotriazole, kynureninę, 3-chlorotyrozynę, bromotyrozynę, sulfotlenek metioniny, dityrozynę, oksohistydynę oraz tzw. zaawansowane produkty oksydacji białek (AOPP).
    W ocenie oksydacyjnych uszkodzeń białek u zwierząt laboratoryjnych najlepiej sprawdzają się pochodne karbonylowe, 3-nitrotyrozyna i AOPP. Ich zawartość w ustroju wyraźnie wzrasta w odpowiedzi na stres oksydacyjny wywołany takimi czynnikami, jak: niewłaściwa dieta, niedobór mikroelementów, zatrucie substancjami toksycznymi, infekcje czy starzenie.
    The prevalence of prooxidative processes in the body is associated with development of oxidative stress, one of the symptoms of which is oxidation of proteins. Direct analysis of the amount of reactive forms of oxygen and nitrogen is a very difficult task. Therefore, in assessing the severity of oxidative stress, markers generated by free radical reactions with proteins are often used. They are much more durable and thus easier to analyze. The most important biomarkers of oxidative damage of proteins are protein carbonyl compounds, 3-nitrothyrosine, S-nitrotriazoles, kynurenine, 3-chlorothyrozine, bromothyroxine, methionine sulfoxide, dithyrosine, oxohistidine and and so called advanced oxidation protein products (AOPP).
    Protein carbonyls, 3-nitrotyrosine and AOPP are the best indicators for evaluating of oxidative damage of proteins in laboratory animals. Their content in the body is clearly increasing in response to oxidative stress caused by such factors as improper diet, micronutrient deficiencies, toxic poisoning, infections or aging.
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-9 z 9

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