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Wyświetlanie 1-10 z 20
Tytuł:
Gene expression pattern in canine mammary osteosarcoma
Autorzy:
Pawlowski, K.
Majewska, A.
Szyszko, K.
Dolka, I.
Motyl, T.
Krol, M.
Tematy:
bone tumour
canine mammary osteosarcoma
gene expression
mammary osteosarcoma
microarray
osteosarcoma
transcriptome
tumour
sarcoma
proliferation
aggressive tumour
gene list
Pokaż więcej
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Powiązania:
https://bibliotekanauki.pl/articles/32248.pdf  Link otwiera się w nowym oknie
Opis:
Canine mammary sarcomas are usually very aggressive and easily metastasize. Unfortunately the biology of this type of tumor is not well known because they are a very rare type of tumors. The aim of this study was to find differences in gene expression patterns in canine mammary osteosarcomas (malignant) versus osteomas (benign) using DNA microarrays. Our microarray experiment showed that 11 genes were up-regulated in osteosarcoma in comparison to osteoma whereas 36 genes were down-regulated. Among the up-regulated genes were: PDK1, EXT1, and EIF4H which are involved in AKT/PI3K and GLI/Hedgehog pathways. These genes play an important role in cell biology (cancer cell proliferation) and may be essential in osteosarcoma formation and development. Analyzing the down-regulated genes, the most interesting seemed to be HSPB8 and SEPP1. HSPB8 is a small heat shock protein that plays an important role in cell cycle regulation, apoptosis, and breast carcinogenesis. Also SEPP1 may play a role in carcinogenesis, as its down-regulation may induce oxidative stress possibly resulting in carcinogenesis. The preliminary results of the present study indicate that the up-regulation of three genes EXT1, EIF4H, and PDK1 may play an essential role in osteosarcoma formation, development and proliferation. In our opinion the cross-talk between GLI/Hedgehog and PI3K/AKT pathways may be a key factor to increase tumor proliferation and malignancy.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Accuracy of various MRI sequences in determining the tumour margin in musculoskeletal tumours
Autorzy:
Walter, Noel
Madhuri, Vrisha
Gibikote, Sridhar
Putta, Tharani
Opis:
BACKGROUND: It is imperative that bone tumour margin and extent of tumour involvement are accurately assessed pre-operatively in order for the surgeon to attain a safe surgical margin. In this study, we comprehensively assessed each of the findings that influence surgical planning, on various MRI sequences and compared them with the gold standard - pathology. MATERIAL AND METHODS: In this prospective study including 21 patients with extremity bone tumours, margins as seen on various MRI sequences (T1, T2, STIR, DWI, post-gadolinium T1 FS) were measured and biopsies were obtained from each of these sites during the surgical resection. The resected tumour specimen and individual biopsy samples were studied to assess the true tumour margin. Margins on each of the MRI sequences were then compared with the gold standard - pathology. In addition to the intramedullary tumour margin, we also assessed the extent of soft tissue component, neurovascular bundle involvement, epiphyseal and joint involvement, and the presence or absence of skip lesions. RESULTS: T1-weighted imaging was the best sequence to measure tumour margin without resulting in clinically significant underestimation or overestimation of the tumour extent (mean difference of 0.8 mm; 95% confidence interval between -0.9 mm to 2.5 mm; inter-class correlation coefficient of 0.998). STIR and T1 FS post-gadolinium imaging grossly overestimated tumour extent by an average of 16.7 mm and 16.8 mm, respectively (P values <0.05). Post-gadolinium imaging was better to assess joint involvement while T1 and STIR were the best to assess epiphyseal involvement. CONCLUSIONS: T1-weighted imaging was the best sequence to assess longitudinal intramedullary tumour extent. We suggest that osteotomy plane 1.5 cm beyond the T1 tumour margin is safe and also limits unwarranted surgical bone loss. However, this needs to be prospectively proven with a larger sample size.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Dual effect of 2-methoxyestradiol on cell cycle events in human osteosarcoma 143B cells.
Autorzy:
Gołębiewska, Justyna
Rozwadowski, Piotr
Spodnik, Jan
Knap, Narcyz
Wakabayashi, Takashi
Woźniak, Michał
Tematy:
osteosarcoma 143B cells
2-methoxyestradiol
apoptosis
cell cycle
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Wydawca:
Polskie Towarzystwo Biochemiczne
Powiązania:
https://bibliotekanauki.pl/articles/1043807.pdf  Link otwiera się w nowym oknie
Opis:
We have demonstrated for the first time that the steroid metabolite, 2-methoxyestradiol (2-ME) is a powerful growth inhibitor of human osteosarcoma 143 B cell line by pleiotropic mechanisms involving cell cycle arrest at two different points and apoptosis. The ability of 2-ME to inhibit cell cycle at the respective points has been found concentration dependent. 1 μM 2-ME inhibited cell cycle at G1 phase while 10 μM 2-ME caused G2/M cell cycle arrest. As a natural estrogen metabolite 2-ME is expected to perturb the stability of microtubules (MT) in vivo analogously to Taxol - the MT binding anticancer agent. Contrary to 2-ME, Taxol induced accumulation of osteosarcoma cells in G2/M phase of cell cycle only. The presented data strongly suggest two different mechanisms of cytotoxic action of 2-ME at the level of a single cell.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Clinico-epidemiologic review of 91 cases of non-odontogenic sarcomas of the orofacial region in a Nigerian population
Autorzy:
Agbara, Rowland
Fomete, Benjamin
Omeje, Kelvin
Onyebuchi, Polycarp
Tematy:
delayed presentation
health resources
jaw
osteosarcoma
patient compliance
sarcoma
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Wydawca:
Index Copernicus International
Powiązania:
https://bibliotekanauki.pl/articles/1399449.pdf  Link otwiera się w nowym oknie
Opis:
Introduction: Sarcomas are a rare group of malignant tumours. This study highlights important findings in 91 cases of nonodontogenic sarcomas of the orofacial region. Materials and Methods: Patients who presented with orofacial sarcoma at the Oral and Maxillofacial Surgery Department of a regional University Teaching Hospital between January 1997 and June 2017 were retrospectively studied. Excluded were cases of Kaposi and odontogenic sarcomas. Data obtained were analyzed using Statistical Package for Social Sciences (SPSS) version 16 (SPSS Inc., Chicago, IL, USA). Results from descriptive statistics were represented in the form of charts. Results: A total of 91 cases were reviewed and consisted of 51 (56.0%) males and 40 (44.0%) females, with a male to female ratio of 1.3:1. The mandible (n = 47; 51.6%) and the maxilla (n = 26; 28.6%) were the major sites involved. Osteogenic sarcoma (n = 44; 48.4%) and rhabdomyosarcoma (n = 16; 17.6%) occurred more frequently. A total of 41 (45.1%) patients had surgery and the common hard tissue procedures were mandibulectomy (n = 26; 28.6%) and maxillectomy (n = 10; 11.0%). Discussion: Most recurrences were noted less than one year post treatment. There is a tendency for patients to present late and compliance with follow-up review is poor in this environment.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Elevated expression of serine/threonine phosphatase type 5 correlates with malignant proliferation in human osteosarcoma
Autorzy:
Han, Kun
Gan, Zhihua
Lin, Shuchen
Hu, Haiyan
Shen, Zan
Min, Daliu
Tematy:
cell proliferation
lentivirus
Osteosarcoma
PP5
siRNA
targeted therapy
Pokaż więcej
Wydawca:
Polskie Towarzystwo Biochemiczne
Powiązania:
https://bibliotekanauki.pl/articles/1038676.pdf  Link otwiera się w nowym oknie
Opis:
Osteosarcoma is the most common primary malignant bone tumor in adolescents and young adults. However, the involvement of serine/threonine phosphatase type 5 (PP5) in osteosarcoma remains unclear. The aim of this study was to evaluate the functional role of PP5 in osteosarcoma cells. Firstly, we found that PP5 is widely expressed in several human osteosarcoma cell lines. Then we used lentivirus-delivered siRNA to silence PP5 expression in Saos-2 and U2OS cell lines. Knockdown of endogenous PP5 expression by shRNA-expressing lentivirus significantly decreased the viability and proliferation of the osteosarcoma cells. Moreover, FACS analysis showed that knockdown of PP5 expression induced a significant arrest in the G0/G1 phase of the cell cycle, which was associated with the inhibition of cell proliferation. Therefore, knockdown of PP5 is likely to provide a novel alternative to targeted therapy of osteosarcoma and deserves further investigation.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Diagnostic imaging of primary malignant bone tumors in children (osteosarcoma, Ewings sarcoma) : part I
Opis:
Neoplastic conditions of developmental period are an important problem in oncology and pediatrics. Multi-agent chemotherapy introduced in the 1970’s significantly improved the results of treatment but still these tumors are the 2nd cause of death in children and adolescents. Primary malignant bone tumors account for 1-1.5% of all neoplasms and for 7% of developmental period tumors. Depending on the kind of tissue, bone tumors demonstrate various patterns of growth, infiltration and internal architecture. Imaging methods are an important part of diagnostics and the most effective tool of monitoring response to treatment. Plains films were the only imaging technique for many years. In the 2nd half of 20th century, angiography was introduced. Despite invasiveness, it showed malignant character of the tumor and its extension in soft tissues. In the 7th decade of the last century, ultrasound and computed tomography started being routinely used in clinical practice. After a few years, resolution of these modalities was improved so that they could better visualize musculoskeletal tumors. Magnetic resonance imaging was the next step, this method came into use in Poland 16 years ago. MRI is the best modality to show the extent of marrow involvement. All the imaging techniques have their place in the diagnostic algorithm of bone tumors. Scintigraphy plays an important role in detecting skeletal metastases and disseminated disease. Fusion of radiological and nuclear medicine methods, PET-CT, brings new possibilities to musculoskeletal tumor diagnostics.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Diagnostic imaging of primary malignant bone tumors in children (osteosarcoma, Ewings sarcoma) : part II
Opis:
Neoplastic conditions of developmental period are an important problem in oncology and pediatrics. Multi-agent chemotherapy introduced in the 1970's of the last century significantly improved the results of treatment but still these tumors are the 2nd cause of death in children and adolescents. Primary malignant bone tumors account for 1-1.5% of all neoplasms and for 7% of developmental period tumors. Depending on the kind of tissue, bone tumors demonstrate various patterns of growth, infiltration and internal architecture. Imaging methods are an important part of diagnostics and the most effective tool of monitoring response to treatment. Plains films were the only imaging technique for many years. In the 2nd half of 20th century, angiography was introduced. Despite invasiveness, it showed malignant character of the tumor and its extension in soft tissues. In the 7th decade of the last century, ultrasound and computed tomography started being routinely used in clinical practice. After a few years, resolution of these modalities was improved so that they could better visualize musculoskeletal tumors. Magnetic resonance imaging was the next step, this method came into use in Poland 16 years ago. MRI is the best modality to show the extent of marrow involvement, All the imaging techniques have their place in the diagnostic algorithm of bone tumors. Scintigraphy plays an important role in detecting skeletal metastases and disseminated disease. Fusion of radiological and nuclear medicine methods, PET-CT, brings new possibilities to musculoskeletal tumor diagnostics.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Wyświetlanie 1-10 z 20

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