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Wyświetlanie 1-10 z 18
Tytuł:
Effects of Tremella fuciformis-Derived Polysaccharides with Different Molecular Weight on D-Galactose-Induced Aging of Mice
Autorzy:
Luo, Donghui
Liu, Xiaofei
Guan, Jingjing
Jang, Guili
Hua, Yanglin
Zhang, Xinfei
Xu, Xiaofei
Tematy:
mushroom
polysaccharide purification
anti-oxidant activity
anti-aging activity
structure-function relationship
anti-oxidant enzyme
Pokaż więcej
Wydawca:
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Powiązania:
https://bibliotekanauki.pl/articles/16538544.pdf  Link otwiera się w nowym oknie
Opis:
The structure-bioactivity relationship of Tremella fuciformis polysaccharides (TFPs) in anti-aging in vivo is rarely reported. In the present study, a purified TFP, named HM, mainly composed of mannose, fucose, xylose, and glucose in a molar ratio of 4.14:0.98:0.81:0.62, was obtained from the fruiting body of T. fuciformis. Subsequently, two differentially degraded TFPs, named MM and LM, respectively, were prepared by a combined method of ultrasonic irradiation (US) and H2O2 treatment. Their structural properties, scavenging activities against free radicals in vitro, and anti-aging effects on D-galactose-induced aging of mice were determined. The average molecular weight of HM, MM, and LM was 58.3×106, 4.68×106, and 3.14×105 Da, respectively. All three TFPs were devoid of triple helix conformation and exhibited concentration- and molecular weight-dependent scavenging activity against radicals. The TFPs markedly relieved skin aging, effectively attenuated oxidative stress, and significantly decreased inflammation in D-galactose-induced aging mice. MM exhibited the best anti-aging effect among the TFPs. Additionally, TFPs partially restored the alterations in pH and the total content of short-chain fatty acids (SCFAs) in the colon but exhibited various impacts on the content of the individual SCFAs. These findings would provide rational guidance for a better application of TFPs in anti-aging foods and expand our understanding of the structure-function relationship of mushroom polysaccharides.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Melatonin as a potential treatment option in diabetes complications
Autorzy:
Alnaser, Raniah I.
Abed, Mohammed N.
Alassaf, Fawaz A.
Wydawca:
Gdański Uniwersytet Medyczny
Cytata wydawnicza:
Alnaser R. I., Alassaf F. A., Abed M. N. Melatonin as a potential treatment option in diabetes complications Eur J Transl Clin Med 2024;7(2):78-91. https://doi.org/10.31373/ejtcm/192108
Opis:
Recent research indicates that disrupted sleeping and eating patterns along with ageing can contribute to the development of diabetes mellitus (DM) via effects on circadian rhythms and metabolic control. The use of anti- -DM drugs alone is insufficient to achieve control of the reduction in β-cell function, insulin resistance, inflammatory mediation, oxidative stress and the DM-related complications. To prevent micro- and macrovascular DM complications, researchers are exploring the therapeutic potential of melatonin, a hormone secreted from the pineal gland with peak at night-time. We searched the Cochrane Library, PubMed and Google Scholar databases for relevant articles. Review articles, clinical research and case studies about the impact of melatonin on DM complications, the anti-oxidant action of melatonin, anti-inflammatory action of melatonin and the combination of melatonin plus DM drugs were included in this review. One hundred three articles that met our selection criteria, published between November 2004 and January 2024 were analyzed. This review aims to summarize the literature regarding melatonin’s mechanisms of action and potential as a therapeutic option in the treatment of DM complications.
Dostawca treści:
Repozytorium Centrum Otwartej Nauki
Artykuł
Tytuł:
Number of circulating pro-angiogenic cells, growth factor and anti-oxidative gene profiles might be altered in type 2 diabetes with and without diabetic foot syndrome
Autorzy:
Witek, Przemysław
Koblik, Teresa
Józkowicz, Alicja
Kusińska, Katarzyna
Nowak, Witold
Bukowska-Straková, Karolina
Borys, Sebastian
Małecki, Maciej
Dulak, Józef
Opis:
Aims/Introduction. Type 2 diabetes is often complicated by diabetic foot syndrome (DFS). We analyzed the circulating stem cells, growth factor and anti-oxidant gene expression profiles in type 2 diabetes patients without or with different forms of DFS. Materials and Methods. Healthy volunteers (n = 13) and type 2 diabetes patients: (i) without DFS (n = 10); or with (ii) Charcot osteoneuropathy (n = 10); (iii) non-infected (n = 17); (iv) infected (n = 11); and (v) healed ulceration were examined (n = 12). Peripheral blood endothelial progenitor cells (EPC), mesenchymal stem cells (MSC), hematopoietic stem cells (HSC) and very small embryonic-like (VSEL) cells were phenotyped using flow cytometry. Plasma cytokine concentrations and gene expressions in blood cells were measured by Luminex and quantitative real-time polymerase chain reaction assays, respectively. Results. Patients with non-complicated type 2 diabetes showed reduced HMOX1 expression, accompanied by HMOX2 upregulation, and had less circulating EPC, MSC or HSC than healthy subjects. In contrast, VSEL cells were elevated in the type 2 diabetes group. However, subjects with DFS, even with healed ulceration, had fewer VSEL cells, more CD45-CD29+CD90+MSC, and upregulated HMOX1 when compared with the type 2 diabetes group. Patients with Charcot osteopathy had lowered plasma fibroblast growth factor-2. Elevated plasma tumor necrosis factor-α and decreased catalase expression was found in all diabetic patients. Conclusions. Patients with type 2 diabetes and different forms of DFS have an altered number of circulating stem cells. Type 2 diabetes might also be associated with a changed plasma growth factor and anti-oxidant gene expression profile. Altogether, these factors could contribute to the pathogenesis of different forms of DFS.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Double-edged sword behaviour of gallic acid and its interaction with peroxidases in human microvascular endothelial cell culture (HMEC-1). Antioxidant and pro-oxidant effects
Autorzy:
Serrano, José
Cipak, Ana
Boada, Jordi
Gonzalo, Hugo
Cacabelos, Daniel
Cassanye, Anna
Pamplona, Reinald
Zarkovic, Neven
Portero-Otin, Manuel
Tematy:
gallic acid
peroxidase
pro-oxidant
antioxidant
HMEC-1
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Wydawca:
Polskie Towarzystwo Biochemiczne
Powiązania:
https://bibliotekanauki.pl/articles/1040403.pdf  Link otwiera się w nowym oknie
Opis:
A previous report from our group had shown in vitro a direct interaction between peroxidases and dietary antioxidants at physiological concentrations, where in the absence of H2O2, the antioxidants could serve as oxidizing substrates for the peroxidases. However, the physiological relevance of those findings had not been evaluated. The main objective of this study was to determine whether the oxidizing products produced in the interaction between peroxidase and gallic acid at a physiological concentration of 1 µM may promote cell death or survival in a human microvascular endothelial cell line (HMEC-1). Our findings suggested that gallic acid may show a double-edged sword behaviour, since in the absence of H2O2 it may have a pro-oxidant effect which may promote cell injury (evidenced by LDH, Crystal Violet and calcein AM viability/citotoxicity assays), while in the presence of H2O2, gallic acid may act as an antioxidant inhibiting oxidative species produced in the peroxidase cycle of peroxidases. These observations were confirmed with several oxidative stress biomarkers and the evaluation of the activation of cell survival pathways like AKT and MAPK/ERK.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antioxidant and antimicrobial potentials of mycelial extracts of Hohenbuehelia myxotricha grown in different liquid culture media
Autorzy:
Krupodorova, T.
Barshteyn, V.
Sevindik, M.
Tematy:
antioxidant
oxidant
antimicrobial
ethanolic extracts
mycelium
Hohenbuehelia myxotricha
Pokaż więcej
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Powiązania:
https://bibliotekanauki.pl/articles/2096244.pdf  Link otwiera się w nowym oknie
Opis:
In addition to their nutritional properties, mushrooms have emerged as a health supplement because of their medicinal potential. Many studies have shown that mushrooms exhibit important biological activities. Here, the antioxidant and antimicrobial activities of Hohenbuehelia myxotricha (Lév.) Singer mycelia cultivated on Sabouraud dextrose broth (SDB) and glucose peptone yeast (GPY) medium were studied. The total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) of ethanolic extracts of mycelia were measured using Rel Assay kits. The antioxidant and oxidant potentials of H. myxotricha mycelial extracts were determined for the first time in the present study. The highest TAS, TOS, and OSI values of H. myxotricha were 5.416 ± 0.150 mmol/l, 1.320 ± 0.156 μmol/l, and 0.024 ± 0.003, respectively. Ethanolic mycelial extracts of H. myxotricha showed antimicrobial activities at concentrations from 25 to 200 μg/ml against all the studied bacteria (Acinetobacter baumannii, Enterococcus faecalis, Escherichia coli, Staphylococcus aureus, methicillin-resistant S. aureus, and Pseudomonas aeruginosa ) and fungi (Candida albicans, C. glabrata, and Issatchenkia orientalis ) tested by the agar dilution method. The antifungal activity of the extract was more significant than its antibacterial activity. The antioxidant, oxidant, and antimicrobial potentials of H. myxotricha mycelia varied depending on the culture media used. GPY medium was more suitable for the synthesis of antibiotic compounds against E. coli, while SDB medium was more appropriate for producing metabolites with antioxidant and antifungal properties. Based on the results, ethanolic extract of H. myxotricha mycelia showed a significant pharmacological potential and could be used as a natural antioxidative and antimicrobial source for health benefit.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Melatonin as a potential treatment option in diabetes complications
Autorzy:
Alnaser, Raniah I.
Alassaf, Fawaz A.
Abed, Mohammed N.
Tematy:
melatonin
anti-oxidant
diabetes mellitus
complications
Pokaż więcej
Wydawca:
Gdański Uniwersytet Medyczny
Powiązania:
https://bibliotekanauki.pl/articles/62762282.pdf  Link otwiera się w nowym oknie
Opis:
Recent research indicates that disrupted sleeping and eating patterns along with ageing can contribute to the development of diabetes mellitus (DM) via effects on circadian rhythms and metabolic control. The use of anti-DM drugs alone is insufficient to achieve control of the reduction in β-cell function, insulin resistance, inflammatory mediation, oxidative stress and the DM-related complications. To prevent micro- and macrovascular DM complications, researchers are exploring the therapeutic potential of melatonin, a hormone secreted from the pineal gland with peak at night-time. We searched the Cochrane Library, PubMed and Google Scholar databases for relevant articles. Review articles, clinical research and case studies about the impact of melatonin on DM complications, the anti-oxidant action of melatonin, anti-inflammatory action of melatonin and the combination of melatonin plus diabetes drugs were included in this review. One hundred three articles that met our selection criteria, published between November 2004 and January 2024 were analyzed. This review aims to summarize the literature regarding melatonin’s mechanisms of action and potential as a therapeutic option in the treatment of DM complications.
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 18

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