Temat: oxyhemoglobin - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Flavonoids as reductants of ferryl hemoglobin
Autorzy:: Gebicka, Lidia
Banasiak, Ewa
Tematy:: methemoglobin
ferryl hemoglobin
oxyhemoglobin
flavonoids; Pokaż więcej
Wydawca:: Polskie Towarzystwo Biochemiczne
Powiązania:: https://bibliotekanauki.pl/articles/1040549.pdf Link otwiera się w nowym oknie
Opis:: The ferryl derivatives of hemoglobin are products of the reactions of oxy- and methemoglobin with hydrogen peroxide. Ferryl hemoglobins, either with or without a radical site on the protein moiety, are oxidizing species. Plant polyphenols, flavonoids, have been shown to act as antioxidants in vivo and in vitro. Reactions of met- and oxyhemoglobin with hydrogen peroxide in the presence of catechin, quercetin and rutin were studied. These flavonoids accelerated reduction of ferryl hemoglobin to methemoglobin. The rate constants of the reactions of ferryl hemoglobin with catechin, quercetin and rutin were in the order of 102 M-1 s-1, i.e. similar to the rate constants of ferryl hemoglobin with intracellular reducing compounds like urate or ascorbate. The beneficial effect of flavonoids against oxidative damage of hemoglobin caused by hydroperoxides, reported in the literature, is probably, at least in part, connected with the ability of flavonoids to scavenge ferryl hemoglobin.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Functional MRI – how does it work?
Autorzy:: Truszkiewicz, Adrian
Aebisher, David
Przypek, Aneta
Guz, Wiesław
Bartusik-Aebisher, Dorota
Tematy:: deoxyhemoglobin
oxyhemoglobin
Magnetic Resonance Imaging functional Magnetic Resonance Imaging; Pokaż więcej
Wydawca:: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Powiązania:: https://bibliotekanauki.pl/articles/454947.pdf Link otwiera się w nowym oknie
Opis:: Magnetic Nuclear Resonance (MRI) is a non-invasive tissue imaging method. This technique is based on the influence of a strong magnetic field and electromagnetic wave of strictly defined frequency on the nucleus of elements with non-zero spin. The study describes one of the variants of functional MRI, (fMRI), which has become a key technique in brain imaging. This technique has excellent spatial and temporal resolution and involves a changing signal intensity depending on the degree of oxygenation of the blood. Blood oxygenation levels are known to vary in accordance with neural activity and these differences can be used to detect brain activity. This is due to increased demand for energy and oxygen in the area of increased neural activity. The basis of this imaging is the so-called Blood Oxygenation-Level Dependent (BLOD) effect. The aim of this paper is to present the scope of fMRI as a diagnostic method in neurology and in neurosurgery. This paper presents the principles of fMRI, methods of application, research result development, and suggests areas of possible medical applications. The limitations of fMRI as a clinical tool in medical applications will also be addressed. Studies presented in this paper are based on clinical fMRI experience and a literature review.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Modeling of the influence of elevated temperature on oxygen distribution in soft tissue
Autorzy:: Jasiński, Marek
Zadoń, Maria
Tematy:: bioheat transfer
tissue thermal damage
oxygen transport
Krogh cylinder
oxyhemoglobin dissociation curve
finite difference method
shooting method
sensitivity analysis; Pokaż więcej
Wydawca:: Instytut Podstawowych Problemów Techniki PAN
Powiązania:: https://bibliotekanauki.pl/articles/38910037.pdf Link otwiera się w nowym oknie
Opis:: The purpose of the study was to analyze the combined model of bioheat transfer and oxygen distribution in tissue during exposition to the external heat impulse. The effect of temperature and thermal damage to the tissue on the values of its thermophysical parameters was taken into account. The variable value of the perfusion coefficient affects the blood velocity in the capillary and thus the distribution of the partial oxygen pressure in the tissue. Various models of the oxygen dissociation curves were also considered and a sensitivity analysis was performed for the parameters of the oxygen distribution model. In the numerical realization stage, the finite difference method and the shooting method were used.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Numerical analysis of the temperature impact to the oxygen distribution in the biological tissue
Autorzy:: Jasiński, Marek
Tematy:: oxygen transport
Krogh cylinder
oxyhemoglobin dissociation curve
hypoxia
finite difference method
transport tlenu
cylinder Krogha
krzywa dysocjacji oksyhemoglobiny
niedotlenienie
metoda różnic skończonych; Pokaż więcej
Wydawca:: Politechnika Częstochowska. Wydawnictwo Politechniki Częstochowskiej
Powiązania:: https://bibliotekanauki.pl/articles/1839761.pdf Link otwiera się w nowym oknie
Opis:: The aim of the study was to analyze changes in tissue oxygen distribution resulting from temperature changes by the use of the Krogh cylinder model with Michaelis-Menten kinetics. A Hill model was also used to describe the oxyhemoglobin dissociation curve. In particular, variable values of parameters of dissociation curve and blood velocity in capillary were considered. Mathematical description was based on two separate equations for radial and axial directions. An additional task related to determination of the temperature, tissue thermal damage and perfusion was also solved. At the stage of numerical realization, the finite difference method was used.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Oddziaływania nadsubtelne w kompleksach hemoglobiny
Hyperfine interactions in hemoglobin complexes
Autorzy:: Grabska, Agata
Opis:: Praca dyplomowa skupia się na zbadaniu struktury nadsubtelnej dwóch najpowszechniej występujących kompleksów hemoglobiny – methemoglobiny i oksyhemoglobiny. Jako metodę badawczą wykorzystano spektroskopię mössbauerowską ze względu na obecność żelaza w obu związkach. Pomiary prowadzone były w różnych temperaturach z zakresu: 5 - 295 K, jak również w obecności zewnętrznego pola magnetycznego o indukcji 8 T. Dodatkowo przeprowadzono analizy komplementarne metodą spektroskopii UV-Vis ze względu na fakt, że podana technika jest skuteczna w określeniu stanu utlenienia żelaza obecnego w hemoproteinach.Pracę podzielono na cztery części – część teoretyczną, część doświadczalną, wyniki oraz podsumowanie. Część teoretyczna zawiera podstawowe informacje o hemoglobinie i jej wybranych kompleksach. Ponadto traktuje o dwóch wykorzystanych technikach badawczych – spektroskopii mössbauerowskiej i spektroskopii absorpcyjnej UV-Vis. W części doświadczalnej przedstawiono badane związki i sprzęt używany podczas eksperymentu. W przypadku spektroskopii UV-Vis zawarto również opis przygotowania próbek i procedury przeprowadzania pomiarów. W dwóch ostatnich częściach przedstawiono wyniki w postaci widm i opisujących je parametrów oraz podsumowanie przeprowadzonych badań.
The thesis focuses on examining the hyperfine structure of two most common hemoglobin complexes – methemoglobin and oxyhemoglobin. Mössbauer spectroscopy was used as a research method due to the presence of iron in both compounds. Measuerments were carried out in the temperature range: 5 - 295 K as well as in the external magnetic field of 8 T. Additionally, UV-Vis spectroscopy was used as a method of complementary anylises because of a very effective way of determining oxidation state of the iron in hemeproteins.The paper was divided into four parts – the theoretical part, the experimental part and the parts presenting results and summary. The theoretical part consists of basic information about hemoglobin and its complexes. Besides, it deals with used research methods – Mössbauer spectroscopy and UV-Vis spectroscopy. In the experimental part there were presented the measured samples and the equipment used during experiment. In the case of UV-Vis spectroscopy this section includes also a description of preparing samples and procedure of the measurements. The last two parts contains the results gained in the form of spectra, determined parameters and also a discussion of the conducted experiments.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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