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Wyświetlanie 1-10 z 217
Tytuł:
Innovation in cosmetics
Autorzy:
Prokopowicz, Monika
Różycki, Krzysztof M.
Tematy:
Cosmetics
cosmeceuticals
marine peptides
milk peptides
opioids
peptides
Pokaż więcej
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Powiązania:
https://bibliotekanauki.pl/articles/1179767.pdf  Link otwiera się w nowym oknie
Opis:
Cosmetics market is still rapidly growing with new ranges of cosmetics emerging. New ingredients are added to formulas in order to obtain innovative activity and higher external effects such as anti-aging, anti-inflammatory, antibacterial, regenerating, soothing, relaxing muscles, or simply moisturizing or cleaning. One of the biggest family of innovative ingredients used in cosmetics are peptides. Thanks to their chemical and physiochemical properties, they show various activities that may gain different applications. Compounds derived from natural sources such as milk, plants or marine organisms become especially popular. Their activity may not always stay strictly cosmetic, but also therapeutic as it is shown in cases of opioid peptides derived from milk or anticancer peptides from algae.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Udział peptydów amyloidu beta w modulacji przemian fosfoinozytydów w mózgu
Autorzy:
Zambrzycka, Agata
Współwytwórcy:
Strosznajder, Joanna B.
Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego PAN
Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN
Wydawca:
Instytut Medycyny Doświadczalnej i Klinicznej PAN
Opis:
Bibliogr. s. 121-139
139 s. : wykr. ; 30 cm
Dostawca treści:
RCIN - Repozytorium Cyfrowe Instytutów Naukowych
Książka
Tytuł:
Characterization of a possible uptake mechanism of selective antibacterial peptides
Autorzy:
Polanco, Carlos
Samaniego, José
Castañón-González, Jorge
Buhse, Thomas
Sordo, Marili
Tematy:
Polarity index method
cell penetrating peptides
selective antibacterial peptides
Pokaż więcej
Wydawca:
Polskie Towarzystwo Biochemiczne
Powiązania:
https://bibliotekanauki.pl/articles/1039457.pdf  Link otwiera się w nowym oknie
Opis:
Selective antibacterial peptides containing less than 30 amino acid residues, cationic, with amphipathic properties, have been the subject of several studies due to their active participation and beneficial effects in strengthening the immune system of all living organisms. This manuscript reports the results of a comparison between the group of selective antibacterial peptides and another group called "cell penetrating peptides". An important number of the selective antibacterial peptides are cell penetrating peptides, suggesting that their toxicity is related to their uptake mechanism. The verification of this observation also includes the adaptation of a method previously published, called Polarity index, which reproduces and confirms the action of this new set of peptides. The efficiency of this method was verified based on four different databases, yielding a high score. The verification was based exclusively on the peptides already reported in the databases which have been experimentally verified.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Interactions of Galleria mellonella proline-rich antimicrobial peptides with Gram-negative and Gram-positive bacteria
Autorzy:
Mak, Paweł
Zdybicka-Barabas, Agnieszka
Stączek, Sylwia
Wydrych, Jerzy
Cytryńska, Małgorzata
Pawlikowska-Pawlęga, Bożena
Gruszecki, Wiesław I.
Kapral-Piotrowska, Justyna
Skrzypiec, Krzysztof
Opis:
Two proline-rich antimicrobial peptides (PrAMPs), named P1 and P2, purified from hemolymph of the greater wax moth Galleria mellonella, were studied for their effects on Gram-negative (Escherichia coli) and Gram-positive (Micrococcus luteus) bacteria. Both peptides decreased the M. luteus bacterial survival rate and caused E. coli bacterial membrane permeabilization. However, in both cases, the P2 peptide was approximately three times more effective than the P1 peptide. Fluorescence microscopy imaging demonstrated binding of both FITC-labeled peptides to E. coli and M. luteus cells. Atomic force microscopy (AFM) and scanning electron microscopy (SEM) imaging of peptide-treated bacteria revealed considerable changes in cell morphology, cell surface topography, and nanomechanical properties. The interactions of the PrAMPs with bacterial cells were also analyzed by FTIR spectroscopy. The P1 peptide action toward E. coli led to partial aggregation of proteins, whereas treatment with P2 resulted in reduced protein aggregation, reflecting differences between both G. mellonella PrAMPs antibacterial action. Moreover, both PrAMPs caused a decrease and an increase in the protein content in relation to lipids on the E. coli and M. luteus cell surface, respectively. The obtained results reflect not only differences between the G. mellonella P1 and P2 peptides but also differences in the cell surface between Gram-negative and Gram-positive bacteria. Both characterized G. mellonella PrAMPs are further representatives of proline-rich peptides with a membrane-permeabilizing antimicrobial mode of action.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Lipidation of temporin-1CEb derivatives as a tool for activity improvement, pros and cons of the approach
Autorzy:
Pikuła, Michał
Wyrzykowski, Dariusz
Obuchowski, Michał
Deptula, Milena
Kosikowska-Adamus, Paulina
Lesner, Adam
Sikorska, Emilia
Golda, Anna
Prahl, Adam
Walewska, Aleksandra
Opis:
The alarming raise of multi-drug resistance among human microbial pathogens makes the development of novel therapeutics a priority task. In contrast to conventional antibiotics, antimicrobial peptides (AMPs), besides evoking a broad spectrum of activity against microorganisms, could offer additional benefits, such as the ability to neutralize toxins, modulate inflammatory response, eradicate bacterial and fungal biofilms or prevent their development. The latter properties are of special interest, as most antibiotics available on the market have limited ability to diffuse through rigid structures of biofilms. Lipidation of AMPs is considered as an effective approach for enhancement of their antimicrobial potential and in vivo stability; however, it could also have undesired impact on selectivity, solubility or the aggregation state of the modified peptides. In the present work, we describe the results of structural modifications of compounds designed based on cationic antimicrobial peptides DK5 and CAR-PEG-DK5, derivatized at their N-terminal part with fatty acids with different lengths of carbon chain. The proposed modifications substantially improved antimicrobial properties of the final compounds and their effectiveness in inhibition of biofilm development as well as eradication of pre-formed 24 h old biofilms of Candida albicans and Staphylococcus aureus. The most active compounds (C5-DK5, C12-DK5 and C12-CAR-PEG-DK5) were also potent against multi-drug resistant Staphylococcus aureus USA300 strain and clinical isolates of Pseudomonas aeruginosa. Both experimental and in silico methods revealed strong correlation between the length of fatty acid attached to the peptides and their final membranolytic properties, tendency to self-assemble and cytotoxicity.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Comparative study of the potential cell-penetrating peptide $\Delta M4$ on apoptosis cell signaling in A375 and A431 cancer cell lines
Autorzy:
Brankiewicz, Aleksandra
Guevara Lora, Ibeth
Manrique-Moreno, Marcela
Fandino-Devia, Estefanía
Santa-González, Gloria A.
Opis:
In recent yearsjajajj, peptide-based therapeutics have attracted increasing interest as a potential approach to cancer treatment. Peptides are characterized by high specificity and low cytotoxicity, but they cannot be considered universal drugs for all types of cancer. Of the numerous anticancer-reported peptides, both natural and synthetic, only a few have reached clinical applications. However, in most cases, the mechanism behind the anticancer activity of the peptide is not fully understood. For this reason, in this work, we investigated the effect of the novel peptide $\Delta M4$, which has documented anticancer activity, on two human skin cancer cell lines. A novel approach to studying the potential induction of apoptosis by anticancer peptides is the use of protein microarrays. The results of the apoptosis protein study demonstrated that both cell types, skin malignant melanoma (A375) and epidermoid carcinoma (A431), exhibited markers associated with apoptosis and cellular response to oxidative stress. Additionally, ∆M4 induced concentration- and time-dependent moderate ROS production, triggering a defensive response from the cells, which showed decreased activation of cytoplasmic superoxide dismutase. However, the studied cells exhibited a differential response in catalase activity, with A375 cells showing greater resistance to the peptide action, possibly mediated by the Nrf2 pathway. Nevertheless, both cell types showed moderate activity of caspases 3/7, suggesting that they may undergo partial apoptosis, although another pathway of programmed death cannot be excluded. Extended analysis of the mechanisms of action of anticancer peptides may help determine their effectiveness in overcoming chemoresistance in cancerous cells.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Aromatic peptides as components of potential scaffolds for regenerative medicine
Autorzy:
Strzempek, W.
Menaszek, E.
Dziadek, M.
Stodolak-Zych, E.
Boguń, M.
Kolesińska, B.
Tematy:
peptides
components
regenerative medicine
Pokaż więcej
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Powiązania:
https://bibliotekanauki.pl/articles/284726.pdf  Link otwiera się w nowym oknie
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthetic phosphoserine-tethered hyperbranched peptides as biomimetic coatings for medical implants
Autorzy:
Stϋbinger, S.
Nuss, K.
Bϋrki, A.
Mosch, I.
Sidler, M.
Meikle, S. T.
Rechenberg von, B.
Santin, M.
Tematy:
peptides
implants
biomimetic coatings
Pokaż więcej
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Powiązania:
https://bibliotekanauki.pl/articles/284800.pdf  Link otwiera się w nowym oknie
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 217

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