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    Wyświetlanie 1-7 z 7
    Tytuł:
    Analiza skryningowa czternastu klasycznych leków psychotropowych metodą NACE
    Screening analysis of fourteen classic psychotropic drugs by the non-aqueous capillary electrophoresis method
    Autorzy:
    Madej, Katarzyna
    Marczyk, Anna
    Woźniakiewicz, Michał
    Opis:
    In our examinations, sixteen psychotropic drugs from the phenothiazines and tricyclic antidepressants group were studied. For the purpose o f screening analysis, the separation conditions of the drugs were studied using capillary electrophoresis in a non-aqueous medium. The influence of both background electrolyte composition and the kind o f medium used for dissolution o f the drugs on the separation efficiency was examined. Noxiptyline was selected as the internal standard. In optimal separation conditions, the identification parameter - relative migration time (RMT) - and repeatability of the identification parameter for each drug tested were determined.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
    Tytuł:
    Interaction of phenothiazines, stilbenes and flavonoids with multidrug resistance-associated transporters, P-glycoprotein and MRP1
    Autorzy:
    Wesołowska, Olga
    Tematy:
    multidrug resistance-associated protein 1 (MRP1,ABCC1)
    P-glycoprotein (ABCB1)
    phenothiazines
    multidrug resistance reversal
    stilbenes
    flavonoids
    Pokaż więcej
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Powiązania:
    https://bibliotekanauki.pl/articles/1039822.pdf  Link otwiera się w nowym oknie
    Opis:
    Multidrug resistance (MDR) of cancer cells poses a serious obstacle to successful chemotherapy. The overexpression of multispecific ATP-binding cassette transporters appears to be the main mechanism of MDR. A search for MDR-reversing agents able to sensitize resistant cells to chemotherapy is ongoing in the hope of their possible clinical use. Studies of MDR modulators, although they have not produced clinically beneficial effects yet, may greatly enrich our knowledge about MDR transporters, their specificity and mechanism of action, especially substrate and/or inhibitor recognition. In the present review, interactions of three groups of modulators: phenothiazines, flavonoids and stilbenes with both P-glycoprotein and MRP1 are discussed. Each group of compounds is likely to interact with the MDR transporters by a different mechanism. Phenothiazines probably interact with drug binding sites, but they also could indirectly affect the transporter's activity by perturbing lipid bilayers. Flavonoids mainly interact with ABC proteins within their nucleotide-binding domains, though the more hydrophobic flavonoids may bind to regions within transmembrane domains. The possible mechanism of MDR reversal by stilbenes may result from their direct interaction with the transporter (possibly within substrate recognition sites) but some indirect effects such as stilbene-induced changes in gene expression pattern and in apoptotic pathways should also be considered. Literature data as well as some of our recent results are discussed. Special emphasis is put on cases when the interactions of a given compound with both P-glycoprotein and MRP1 have been studied simultaneously.
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Inhibitors of bacterial efflux pumps that also inhibit efflux pumps of cancer cells
    Autorzy:
    Martins, Ana
    Handzlik, Jadwiga
    Amaral, Leonard
    Armada, Ana
    Spengler, Gabriella
    Molnar, Joseph
    Kieć-Kononowicz, Katarzyna
    Opis:
    Bacteria and cancer cells frequently increase their resistance to chemotherapeutics as a consequence of therapy. Whenever studied, refractory response to chemotherapy is due to the over-expression of efflux pumps that render the bacterium or cancer cell resistant not only to the agent used for therapy, but to many, if not all other agents as well. Control over the efflux pump that bestows multidrug resistance has been a goal of research during the past decade. As a consequence of this search for inhibitors of efflux pumps, it has been noted that many agents which affect the efflux pump system of bacteria also have similar activity against efflux pumps of drug-resistant cancer cells. This review aims to identify such agents.
    Dostawca treści:
    Repozytorium Uniwersytetu Jagiellońskiego
    Artykuł
      Wyświetlanie 1-7 z 7

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