- Tytuł:
- Blockade of GABA_{A} receptors disrupts isoperiodic neuronal oscillations in the intergeniculate leaflet of the rat
- Autorzy:
-
Lewandowski, Marian
Błasiak, Tomasz - Opis:
- The intergeniculate leaflet of the thalamus is, besides the suprachiasmatic nucleus of the hypothalamus, the other important neuronal element of the mammalian biological clock. The extracellularly recorded activity of neurons constituting the intergeniculate leaflet, recorded in vivo, is characterized by distinct, very regular ultradian oscillations. The majority of neurons in the circadian timing system are GABAergic. Many, if not all, neurons of the suprachiasmatic nucleus and intergeniculate leaflet contain GABA. In the present study we examined the effects of the GABA_{A} receptor antagonist bicuculline and the chloride channel blocker picrotoxin on isoperiodic neuronal oscillations in the intergeniculate leaflet of rats. We recorded extracellular multiple-unit neuronal activity from the intergeniculate leaflet of anesthetized rats. During the recording of isoperiodic oscillations, bicuculline or picrotoxin were stereotaxically injected at different concentrations into the lateral ventricle of rat brain. In all the experiments, injection of GABA_{A} receptor antagonists transiently disrupted the isoperiodic phasic discharge recorded from the intergeniculate leaflet. These data suggest that GABA_{A} receptors are involved in the generation of ultradian rhythmical neuronal oscillations in rat intergeniculate leaflet.
- Dostawca treści:
- Repozytorium Uniwersytetu Jagiellońskiego
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