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Wyświetlanie 1-10 z 13
Tytuł:
Aluminum nanoparticles affect human platelet function in vitro
Autorzy:
Pękala, Przemysław
Skinningsrud, Bendik
Taterra, Dominik
Szwedowski, Dawid
Tomaszewska, Iwona
Tomaszewski, Krzysztof
Lauritzen, Sigurd S.
Opis:
Endoprostheses are prone to tribological wear and biological processes that lead to the release of particles, including aluminum nanoparticles (Al NPs). Those particles can diffuse into circulation. However, the toxic effects of NPs on platelets have not been comprehensively analyzed. The aim of our work was to investigate the impact of Al NPs on human platelet function using a novel quartz crystal microbalance with dissipation (QCM-D) methodology. Moreover, a suite of assays, including light transmission aggregometry, flow cytometry, optical microscopy and transmission electron microscopy, were utilized. All Al NPs caused a significant increase in dissipation (D) and frequency (F), indicating platelet aggregation even at the lowest tested concentration (0.5 µg/mL), except for the largest (80 nm) Al NPs. A size-dependent effect on platelet aggregation was observed for the 5–20 nm NPs and the 30–50 nm NPs, with the larger Al NPs causing smaller increases in D and F; however, this was not observed for the 20–30 nm NPs. In conclusion, our study showed that small (5–50 nm) Al NPs caused platelet aggregation, and larger (80 nm) caused a bridging–penetrating effect in entering platelets, resulting in the formation of heterologous platelet–Al NPs structures. Therefore, physicians should consider monitoring NP serum levels and platelet activation indices in patients with orthopedic implants.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Safety of dental extractions in patients on dual antiplatelet therapy : a meta-analysis
Autorzy:
Ziakas, Antonio
Malinowski, Krzysztof
Lillis, Theodoros
Siudak, Zbigniew
Zabojszcz, Michał
Sławska, Agnieszka
Janion, Marianna
Janion-Sadowska, Agnieszka
Opis:
Introduction: Safety of dental extractions in patients on chronic antiplatelet therapy either with only acetylsalicylic acid (ASA) or clopidogrel or with both combined has been a matter of debate, with no clearly conclusive studies published. Aim: To perform a meta-analysis of published observational studies in order to study the effect of single and double antiplatelet therapy in comparison to controls on the occurrence of immediate local bleeding complications during dental extractions. Material and methods: PubMed/Scopus/Embase database search revealed 22 papers (13 original and 9 review), 3 of which were finally included in the meta-analysis. Phrases searched: dual[All Fields] AND antiplatelet[All Fields] AND (“therapy”[Subheading] OR “therapy”[All Fields] OR “therapeutics”[MeSH Terms] OR “therapeutics”[All Fields]) AND (“tooth extraction”[MeSH Terms] OR (“tooth”[All Fields] AND “extraction”[All Fields]) OR “tooth extraction”[All Fields]). Results: The overall event incidence (bleeding complication after extraction) in the entire population was 1.59% (42 events in 2637 patients). As compared to the control group, the use of double antiplatelet therapy DAPT was associated with on odd ratio OR of 40.23 (95% CI: 4.37–370.36) increase in risk of bleeding events occurrence (p = 0.0011). Significant heterogeneity was observed (p < 0.001; I2 of 76.7%). Conclusions: Dental extractions following strict procedural protocols in patients on double antiplatelet therapy with clopidogrel and ASA are associated with an additional risk of immediate local bleeding complications.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
The effect of some ε-aminocaproic acid derivatives on platelet responses.
Autorzy:
Bruzgo, Irena
Tomasiak, Marian
Stelmach, Halina
Midura-Nowaczek, Krystyna
Tematy:
platelet aggregation
ε-aminocaproic acid derivatives
platelet adhesion
LDH release
Pokaż więcej
Wydawca:
Polskie Towarzystwo Biochemiczne
Powiązania:
https://bibliotekanauki.pl/articles/1043320.pdf  Link otwiera się w nowym oknie
Opis:
ε-Aminocaproic acid (EACA) is a synthetic low molecular drug with antifibrinolytic activity. However, treatment with this drug can be incidentally associated with an increased thrombotic tendency. The aim of the present work was to test synthetic EACA derivatives for their antiplatelet activities. We investigated the effect of three EACA derivatives with antifibrinolytic activity: I. ε-aminocaproyl-L-leucine hydrochloride (HClH-EACA-L-Leu-OH), II. ε-aminocaproyl-L-(S-benzyl)-cysteine hydrochloride (HClH-EACA-L-Cys(S-Bzl)-OH) and III. ε-aminocaproyl-L-norleucine (H-EACA-L-Nle-OH) on platelet responses (aggregation and adhesion) and on their integrity. It was found that: 1. as judged by LDH release test, none of the tested compounds, up to 20 mM, was toxic to platelets, 2. in comparison with EACA, all the synthetic derivatives inhibited much stronger the ADP- and collagen-induced aggregation of platelets suspended in plasma (platelet rich plasma) and aggregation of these cells in whole blood, 3. EACA and its derivatives exerted a similar inhibitory effect on the thrombin-induced adhesion of platelets to fibrinogen-coated surfaces. Since platelet activation and blood coagulation are tightly associated processes, the antiplatelet properties of EACA derivatives are expected to indicate reduced thrombotic properties of these derivatives compared to EACA.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The inhibition of human platelet aggregation by a low-molecular weight chitosan
Autorzy:
Drozd, Natalia N
Logvinova, Yulia S.
Shagdarova, Balzhima Ts.
Il’ina, Alla V.
Varlamov, Valery P.
Tematy:
chitosan
deacetylation degree
depolymerisation
molecular weight
platelet aggregation
Pokaż więcej
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Powiązania:
https://bibliotekanauki.pl/articles/1034373.pdf  Link otwiera się w nowym oknie
Opis:
Chitosan derivatives were obtained by chemical (MW of 6 kDa, DD 99% - Ch6/99; MW13 kDa, DD 98% - Ch13/98) and enzymatic (MW of 5 kDa, DD 85% - Ch5/85; MW of 10 kDa, DD 85% - Ch10/85) depolymeri-sation of chitosan with a MW of 334 and 1000 kDa. Chitosan derivatives (almost identical MW pairs and different DD) possessed insignificant an-ticoagulant activity, did not promote human platelet aggregation and re-duced ADP or collagen-induced platelet aggregation. The studied sam-ples at a concentration of 2 mg/ml reduced the aggregation of platelets more than twice induced in 2x10-6M and 1x10-5M concentrations; at weak activation in 2x10-6M, the Ch10/85 sample was the most effective. The Ch6/99 and Ch13/98 samples were 20 times more effective at the inhibi-tion of collagen-induced platelet aggregation than the Ch10/85 sample. The latter can be explained by the greater value of positive charge (DD) and polydispersity (Mw/Mn) of chitosan samples obtained by chemical de-polymerisation
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Features of the regulation of reparative processes of chronic wounds in response to the effect of photobiomodulation therapy on a wound defect. Photobiomodulation therapy for chronic wounds
Autorzy:
Pavlov, Sergey
Babenko, Nataliia
Kumetchko, Marina
Litvinova, Olga
Tematy:
platelet aggregation
intercellular mediators
histological indicators
remodeling phase
optimization of therapy parameters
Pokaż więcej
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Powiązania:
https://bibliotekanauki.pl/articles/57112729.pdf  Link otwiera się w nowym oknie
Opis:
Background: One of the promising methods of influencing the wound process is photobiomodulation (PBM) therapy. The optimal parameters of PBM therapy have not yet been found because the molecular mechanisms of light interaction with tissue are not fully understood. Objective: Studying the influence of PBM of various parameters on the regulation of reparative processes of chronic wounds using the example of indicators of aggregation activity of platelets, platelet-derived growth factor (PDGF), interleukin-8 (IL-8), and amino-terminal propeptide of type III procollagen (PIIINP) at the remodeling stage. And also the study of the structural and functional features of chronic wound healing in an experiment under various parameters of PBM therapy. Methods: Experiments were carried out on Wistar rats. Chronic wounds were simulated. Experimental animals were exposed to PBM at a wavelength of 660 nm and an energy density of 1 J/cm2. In serum, PDGF, IL-8, and PIIINP levels were measured by enzyme-linked immunosorbent assay. The functional activity of platelets was measured using the turbidimetric method. Histological analysis was performed. Results: The work noted the dose-dependent effect of PBM using the example of platelet aggregation at the remodeling stage during the healing of chronic wounds. The use of PBM therapy resulted in increased serum PDGF levels. Histological examination data indicate a positive effect of PBM therapy on the wound healing process. Conclusions: The effectiveness of the use of PBM therapy for the healing of chronic wounds to regulate reparative processes has been proven.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of caramel carbon quantum dots and caramel on platelet aggregation, protein glycation and lipid peroxidation
Autorzy:
Kotańska, Magdalena
Wojnicki, Marek
Kubacka, Monika
Wojtaszek, Konrad
Nicosia, Noemi
Bednarski, Marek
Opis:
Caramel, defined as a coloring agent and as an antioxidant, is used in several kinds of food products and is consumed by many people in different amounts. In our research we showed that the caramelization of sucrose under special conditions leads to the formation of carbon quantum dots (CQDs). So, it makes sense that humans also consume this type of CQDs, and it is theoretically possible for these particles to affect the body. Despite an increasing number of studies describing different types of CQDs, their biosafety is still not clearly understood. In our in vitro research, we examined the effects on platelet aggregation, protein glycation and lipid peroxidation of CQDs and caramel formed from a 20% sucrose solution. In vitro aggregation tests were conducted using freshly collected whole rat blood in a multiplate platelet function analyzer and measurer of electric impedance. The cytotoxic effect of the tested solutions on blood platelets was evaluated based on the release of lactate dehydrogenase. The formation of glycated bovine serum albumin was measured as fluorescence intensity and fructosamine level. The reducing power of the solutions was determined in adipose tissue, and their effect on lipid peroxidation in adipose tissue in vitro was also assessed. By measuring the intensity of hemolysis after incubation in solutions with red blood cell, we assessed their influence on the integration of the red blood cell membrane. All tests were performed in comparison with glucose and fructose and other frequently used sweeteners, such as erythritol and xylitol. Our study showed that caramel and CQDs formed from caramel may influence the glycation process and integrity of the red blood cell membrane, but unlike glucose and fructose, they decrease lipid peroxidation and may reduce Fe (III). Additionally, it is unlikely that they affect platelet aggregation. Compared to glucose and fructose, they may be safer for patients with metabolic disorders; however, further research is needed on the safety and biological activity of caramel and CQD.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
The Inhibitory Effect of Human Plasma Albumin and Haptoglobin on Platelet Aggregation and 5-HT Release
Autorzy:
Khan, Nadia
Kurnik-Łucka, Magdalena
Latacz, Gniewomir
Gil, Krzysztof
Arshad Saeed, Sheikh
Tematy:
human plasma
endogenous inhibitor of platelet aggregation (EIPA)
arachidonic acid metabolism
affinity chromatography
albumin
haptoglobin
Pokaż więcej
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Powiązania:
https://bibliotekanauki.pl/articles/57065131.pdf  Link otwiera się w nowym oknie
Opis:
Platelet aggregation contributes to the pathogenesis of cardiovascular diseases. After activation it leads to dense granule secretion and 5-HT release. The question arises; how platelet aggregation is endogenously controlled during blood circulation. In preliminary studies, we observed that human plate-lets aggregate more rapidly when suspended in buffer as compared to those suspended in plasma (PRP). These observations point to the presence of an endogenous substance that may inhibit arachidonic acid– induced platelet aggregation. An analysis of plasma Cohn fractions demonstrated that most of the plasma inhibitory activity was associated with albumin–rich and α-globulin rich protein fractions. The identity of plasma endogenous inhibitors of platelet aggregation (EIPA) was established by affinity chromatography on Cibacron Blue F3G-A for specific removal of albumin. The association of α-globulins to EIPA activity was recognized as due to haptoglobin by affinity chromatography on a column of hemoglobin-sepharose. In addition, we also found that the distribution of EIPA activity varies according to sex and physiological state. These findings reveal that EIPA may act by modulation of arachidonic acid metabolism or seques-tering the fatty acid substrate.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analiza interakcji elementów morfotycznych krwi z wybranymi komponentami chemicznymi nanomateriałów
Analysis of the interaction of blood morphotic elements with selected chemical components of nanomaterials
Autorzy:
Majkowska, Natalia
Opis:
The compound commonly used in medicine for the modification of, for example, proteins and nanomaterials is polyethylene glycol (PEG). It has a beneficial effect on the pharmacokinetics of the substance and was considered neutral for the human body for many years. Recent studies, however, indicate, among other things, its immunotoxicity. The properties of PEGs depend on its mass and the type of modification (as methylation). The presented studies analyze seven different types of PEGs in terms of their potential hemolytic properties (destruction of red blood cells) and their ability to activate platelet aggregation. Studies showed no activation of platelets, but one of the tested polymers (mPEG 20,000 g / mol) showed significant hemolytic abilities and two others were at the acceptable limit, above which, compounds are considered to cause hemolysis of erythrocytes.
Związkiem powszechnie wykorzystywanym w medycynie do modyfikacji na przykład białek oraz nanomateriałów jest glikol polietylenowy (PEG). Wpływa on korzystnie na farmakokinetykę substancji i przez wiele lat był uważany za neutralny dla organizmu człowieka. Najnowsze badania wskazują jednak, między innymi, na jego immunotoksyczność. Właściwości PEGów zależą od jego masy cząsteczkowej oraz rodzaju modyfikacji (takich jak metylacja). W poniższej pracy przedstawiono analizę siedmiu różnych rodzajów PEGów pod względem ich potencjalnych właściwości hemolitycznych (powodujących rozpad krwinek czerwonych) oraz zdolności do aktywacji agregacji płytek krwi. Badania wykazały brak aktywacji płytek krwi, jednak jeden z badanych polimerów (mPEG 20 tys. g/mol) wykazał znaczne zdolności hemolityczne, a dwa inne znalazły się na dopuszczalnej granicy, powyżej której związki są już uważane za powodujące hemolizę erytrocytów.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
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Wyświetlanie 1-10 z 13

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