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Tytuł:
Blends of poly(L-lactide) and poly(L-lactide-co-trimethylene carbonate) as promising materials for bone and cartilage tissue engineering
Autorzy:
Marchewka, J.
Laska, J.
Tematy:
poly(L-lactide)
poly(L-lactide-co-trimethylene carbonate)
polymer blends
mechanical properties
biomaterials
Pokaż więcej
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Powiązania:
https://bibliotekanauki.pl/articles/286020.pdf  Link otwiera się w nowym oknie
Opis:
The aim of this work was to evaluate the properties of polymer blends of poly(L-lactide) and poly(L-lactide-co-trimethylene carbonate) 15/85 and to select two compositions to be used to prepare the materials for bone and cartilage tissue engineering. PLLA and PLLATMC as the polymers with significantly different mechanical properties could be used to prepare a wide range of polymer blends. They were investigated by ultimate tensile strength and Young modulus measurements. Considering similar mechanical properties to these types of human tissues PLLA:PLLATMC 80:20 and 30:70 blends have been chosen as appropriate materials for bone and cartilage engineering, respectively. The materials were examined by thermal analysis (thermogravimetry and differential scanning calorimetry), ATR-FTIR spectroscopy and surface analysis (roughness and contact angle measurements). Miscibility of two polymers was discussed. High thermal stability of the blends allow to process them by fused deposition modelling which is one of the most promising methods for the manufacturing of computationally designed scaffolds. Based on the results of thermal analysis at least partial miscibility of PLLA and PLLATMC in the examined blends is indicated. Detailed interpretation of ATR-FTIR spectra let to distinguish the polymers despite their structural similarities. Surface properties of the materials depend on the preparation method and on their form.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of poly(L-lactide) surface modification by CO2 and excimer lasers on mechanical properties
Autorzy:
Tomanik, M.
Kobielarz, M.
Antończak, A.
Filipiak, J.
Pezowicz, C.
Tematy:
polymers
laser surface modification
poly(L-lactide)
Pokaż więcej
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Powiązania:
https://bibliotekanauki.pl/articles/285049.pdf  Link otwiera się w nowym oknie
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and characterization of high-molar-mass star-shaped poly(l-lactide)s
Synteza i charakterystyka gwiaździstych poli(l-laktydów) o dużych masach molowych
Autorzy:
Michalski, A.
Łapienis, G.
Tematy:
poly(l-lactide)
stabilization
DSC
NMR
thermal properties
poli(l-laktyd)
stabilizacja
właściwości termiczne
Pokaż więcej
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Chemii Przemysłowej
Powiązania:
https://bibliotekanauki.pl/articles/947098.pdf  Link otwiera się w nowym oknie
Opis:
The synthesis of high-molar-mass linear and 6-arm star-shaped poly(l-lactide)s(PLLA’s) is presented. Dipentaerythritol and benzyl alcohol were used asinitiators and Sn(Oct)2 was applied asa catalyst in the ring-opening polymerization (ROP) of l-lactide (l-LA) carried out at 130 °C. The prepared PLLA’s were characterized by SEC (size exclusion chromatography), 1H NMR (proton nuclear magnetic resonance spectroscopy), DSC (differential scanning calorimetry), and TGA (thermogravimetric analysis). The structure of the obtained star-shaped polymers was confirmed by comparison of the radii of gyration (Rg) determined by SEC for the linear and star macromolecules. The thermal properties of PLLA’s were shown for the wide range of molar masses. Additionally, it was confirmed that Irganox stabilizer has an influence on the thermal stability of PLLA’s.
Przedstawiono syntezę liniowych i 6-ramiennych gwiaździstych poli(l-laktydów)(PLLA) o dużych masach molowych. Polimeryzację z otwarciem pierścienia (ROP) l-laktydu(l-LA) inicjowaną dipentaerytrytem oraz alkoholem benzylowym prowadzono w temperaturze130 °C wobec Sn(Oct)2 jako katalizatora. Otrzymane PLLA scharakteryzowano za pomocą SEC (chromatografia żelowa), 1HNMR (spektroskopia magnetycznego rezonansu jądrowego), DSC (różnicowa kalorymetria skaningowa) i TGA (analiza termograwimetryczna). Strukturę otrzymanych polimerów gwiaździstych potwierdzono przez porównanie wyznaczonych w SEC promieni bezwładności (Rg) dla gwiaździstych iliniowych makrocząsteczek. Właściwości termiczne PLLA przedstawiono dla szerokiego zakresu mas molowych. Dodatkowo potwierdzono, że stabilizator Irganox ma wpływ na stabilność termiczną PLLA.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of surface and structural properties on the initial release of risperidone from polymeric drug carriers
Autorzy:
Turek, A.
Kasperczyk, J.
Jelonek, K.
Dobrzyński, P.
Walichiewicz, J.
Krzemińska, K.
Smola, A.
Musiał-Kulik, M.
Marcinkowski, A.
Libera, M.
Gębarowska, K.
Tematy:
risperidone
implantable drug carriers
poly(L-lactide-co-glycolide)
poly(DL-lactide-co-glycolide)
initial release
Pokaż więcej
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Powiązania:
https://bibliotekanauki.pl/articles/284323.pdf  Link otwiera się w nowym oknie
Opis:
In this work, implantable drug formulation with risperidone on the basis of poly(L-lactide-co-glycolide) (L-PLGA) and poly(D,L-lactide-co-glycolide) (D,L-PLGA) as drug carries was developed. The influence of surface and structural properties on the initial release of risperidone during the first twenty four hours was determined. In this aim, high-performance liquid chromatography, nuclear magnetic resonance spectroscopy, scanning electron microscope and atomic force microscope were used. Significant differences between L-PLGA and D,L-PLGA matrices in all analyzed data were noted. The burst effect was not revealed for any of the studied polymers, however the released drug was almost five times larger for D,L-PLGA matrices. The L-PLGA copolymer revealed a significantly longer average length of the lactidyl and glycolidyl blocks than D,L-PLGA. Moreover, various characters of surface for analyzed matrices were shown, i.e. in case of L-PLGA the surface was porous and in case of D,L-PLGA it was nonporous. Undoubtedly, there were dependences between risperidone's initial release and the topography and the structure of polymeric matrices. We suppose that the larger drug release for L-PLGA was more associated with surface properties and thus structure of matrices. The obtained results showed the great potential of both polymers and possibility to choose the optimal polymer.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Physical properties of biodegradable polymers exposed to artificial plasma flow
Autorzy:
Zegartowska, Alicja
Stojko, Mateusz
Joszko, Kamil
Goldsztajn, Karolina
Orłowska, Ada
Szewczenko, Janusz
Tematy:
bioresorbable stents
biodegradable coatings
poly(L-lactide-co-glycolide) (PLGA)
splay coating
radial forces
stenty
biomateriały
biodegradacja
Pokaż więcej
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Powiązania:
https://bibliotekanauki.pl/articles/58809850.pdf  Link otwiera się w nowym oknie
Opis:
Despite significant advances in diagnosis and treatment, cardiovascular disease remains a major cause of premature death. Approximately 80% of cardiovascular incidents can be prevented by optimizing risk factor control and lifestyle modification, including dietary change. Treatment of cardiovascular disease, like treatment of other diseases, can be divided into conservative and curative. Conservative treatment is based on pharmacotherapy, while surgical treatment is mainly based on the use of PCI (percutaneous coronary intervention) procedures, i.e., increasing blood flow through narrowed arteries. This effect can be achieved with stents. The main limitation of metal stents is their permanent presence within the body, which can lead to complications such as thrombosis. A more advanced solution is the use of polymer or drug-coated stents, both of which are made of biodegradable materials. These stents are designed to release medications to support treatment and maintain their shape within the blood vessel before being naturally absorbed and eliminated by the body. In this study, the surface of stents made of polylactide was modified by applying a layer of PLGA using an ultrasound method. The study was carried out for uncoated and coated stents in both the initial state and after exposure to artificial plasma flow. The scope of the work included microscopic observations, weight measurements of the specimen, and examination of radial forces. The analysis of the results showed no clear effect of exposure on stent weight, but a clear effect of long- -term exposure on radial forces was observed.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Optimizing manufacturing conditions of polymer microspheres as cell carriers for modular tissue engineering
Autorzy:
Mielan, Bartosz
Pamuła, Elżbieta
Tematy:
modular tissue engineering
microspheres
cell culture
oil-in-water emulsification
poly(L-lactide-co-glycolide) (PLGA)
Pokaż więcej
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Powiązania:
https://bibliotekanauki.pl/articles/1844978.pdf  Link otwiera się w nowym oknie
Opis:
Microspheres (MS) made of biostable polymer, namely polystyrene, have been used as substrates for cell culture enabling rapid cell expansion in dynamic conditions. However, due to non-resorbability, polystyrene (PS) MS when repopulated with cells cannot be directly used in tissue engineering. Our concept was to produce MS from resorbable polymer – poly(L-lactide- -co-glycolide) (PLGA) as a support for adherent cells, e.g. osteoblasts. We hypothesize that such MS can be applied to the injured site to act as cell carriers or as modules for modular tissue engineering (MTE). In this article, we present the results of optimizing the PLGA MS manufacturing conditions via oil-in-water emulsification. Due to such a technique, MS with the required size, size distribution and properties suitable for cell culturing can be obtained. Three parameters of the oil-in-water emulsification were examined: the stirring speed of a water phase during MS manufacturing, the surfactant concentration, i.e. poly(vinyl alcohol) (PVA) in a water phase and concentration of PLGA in dichloromethane (DCM) as an oil phase. The results proved that the 7.5% PLGA concentration in DCM solution as an oil phase, the 0.5-2% concentration of PVA solution as a water phase and the stirring speed of water phase of 1000 rpm provided MS with the 160 μm mean diameter, which is suitable for cell culture. Moreover, the developed sieving and cleaning procedures were efficient to collect MS with the mean diameter of 280 μm, the more coherent size distribution and the ability to sink in the cell culture medium. The presence on the bottom of cell culture wells is crucial for MTE.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Endothelial cells on pet vascular prostheses impregnated with polyester-based copolymers and coated with cell-adhesive protein assemblies
Autorzy:
Chlupac, J.
Filova, E.
Riedel, T.
Brynda, E.
Pamuła, E.
Lisa, V.
Bacakova, L.
Tematy:
vascular prostheses
polyethylene terephtalate
poly(glycolide-L-lactide)
poly(glycolide-L-lactide-(ε)caprolactone)
extracellular matrix
surface modification
collagen
laminin
fibronectin
fibrin
endothelial cells
static cell culture
Pokaż więcej
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Powiązania:
https://bibliotekanauki.pl/articles/284406.pdf  Link otwiera się w nowym oknie
Opis:
Arterial bypass surgery with synthetic vascular prostheses achieves poor patency rates compared to autogenous natural materials, and this is a challenge for tissue engineering research concerning small caliber vascular grafts. Modifications of the prosthetic surface followed by endothelial cell seeding may reduce thrombogenicity and intimal hyperplasia. Planar polyethylene terephthalate (PET) vascular prosthetic samples were impregnated with the copolymer poly(glycolide-L-lactide) (PGL) or with the terpolymer poly(glycolide-L-lactide-(e)caprolactone) (PGLCap) in order to lower the permeability of the knitted fabrics and ensure a less adhesive background. Subsequent modification with adhesive protein assemblies composed of collagen type I (Co) in conjunction with laminin (LM), fibronectin (FN) or fibrin (Fb) gel was performed to enhance cell adhesion. Bovine pulmonary artery endothelial cells (EC) of the CPAE line were seeded on to the coatings and subjected to static tissue culture conditions for 7 days. Impregnation of the PET prostheses decreased the initial adhesion and proliferation of the EC. After coating with the protein assemblies, the impregnated PET provided better substrates for cell culture than the protein-coated PET, on which the EC population started decreasing after 4 days of culture. The cells proliferated better on the CoFN, CoFb and CoFbFN coatings than on the Co and CoLM coatings. Impregnation type and adhesive matrix protein deposition may play an important role in successful endothelialization, healing and clinical performance of vascular grafts.
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 28

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