Temat: prebiotic - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: The citric acid-modified, enzyme-resistant dextrin from potato starch as a potential prebiotic
Autorzy:: Śliżewska, Katarzyna
Tematy:: resistant dextrin
prebiotic
intestinal bacteria; Pokaż więcej
Wydawca:: Polskie Towarzystwo Biochemiczne
Powiązania:: https://bibliotekanauki.pl/articles/1039464.pdf Link otwiera się w nowym oknie
Opis:: In the present study, enzyme-resistant dextrin, prepared by heating of potato starch in the presence of hydrochloric (0.1% dsb) and citric (0.1% dsb) acid at 130ºC for 3 h (CA-dextrin), was tested as a source of carbon for probiotic lactobacilli and bifidobacteria cultured with intestinal bacteria isolated from feces of three healthy 70-year old volunteers. The dynamics of growth of bacterial monocultures in broth containing citric acid (CA)-modified dextrin were estimated. It was also investigated whether lactobacilli and bifidobacteria cultured with intestinal bacteria in the presence of resistant dextrin would be able to dominate the intestinal isolates. Prebiotic fermentation of resistant dextrin was analyzed using prebiotic index (PI). In co-cultures of intestinal and probiotic bacteria, the environment was found to be dominated by the probiotic strains of Bifidobacterium and Lactobacillus, which is a beneficial effect.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Biased versus unbiased randomness in homo-polymers and copolymers of amino acids in the prebiotic world
Autorzy:: Mosqueira, Fernando
Negron, Alicia
Ramos, Sergio
Polanco, Carlos
Tematy:: polarity of amino acids
homo-peptides
prebiotic co-polypeptides
lysine
Markov chain
prebiotic homo polymerization of amino acids; Pokaż więcej
Wydawca:: Polskie Towarzystwo Biochemiczne
Powiązania:: https://bibliotekanauki.pl/articles/1039646.pdf Link otwiera się w nowym oknie
Opis:: The polymerization of amino acids under anhydrous prebiotic conditions was first studied several decades ago. Here we use a stochastic model stressing the relevant role of the polarity of amino acids in the formation of oligopeptides in a prebiotic milieu. Our goal is to outline the predominance of co-polypeptides over homo-polypeptides, resulting not only from the randomness, but also from polarity properties of amino acids. Our results conclude that there was a higher probability of the formation of co-polypeptides than of homo-polymers. Besides, we may hypothesize that the former would have a more ample spectrum of possible chemical functions than homo-polypeptides.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: The polar profile of ancient proteins: a computational extrapolation from prebiotics to paleobiochemistry
Autorzy:: Polanco, Carlos
Buhse, Thomas
Vizcaíno, Gloria
Picciotto, Jacobo
Tematy:: origins of life
prebiotic protein formation
abiogenesis; Pokaż więcej
Wydawca:: Polskie Towarzystwo Biochemiczne
Powiązania:: https://bibliotekanauki.pl/articles/1038695.pdf Link otwiera się w nowym oknie
Opis:: This paper addresses the polar profile of ancient proteins using a comparative study of amino acids found in 25 000 000-year-old shells described in Abelson's work. We simulated the polar profile with a computer platform that represented an evolutionary computational toy model that mimicked the generation of small proteins starting from a pool of monomeric amino acids and that included several dynamic properties, such as self-replication and fragmentation-recombination of the proteins. The simulations were taken up to 15 generations and produced a considerable number of proteins of 25 amino acids in length. The computational model included the amino acids found in the ancient shells, the thermal degradation factor, and the relative abundance of the amino acids observed in the Miller-Urey experimental simulation of the prebiotic amino acid formation. We found that the amino acid polar profiles of the ancient shells and those simulated and extrapolated from the Miller-Urey abundances are coincident.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Prebiotics and bioactive natural substances induce changes of composition and metabolic activities of the colonic microflora in cancerous rats
Autorzy:: Hijová, Emília
Bomba, Alojz
Bertková, Izabela
Strojný, Ladislav
Szabadosová, Viktória
Šoltésová, Alena
Tematy:: Horse chestnut
prebiotic
rats
flaxseed oil
colon cancer; Pokaż więcej
Wydawca:: Polskie Towarzystwo Biochemiczne
Powiązania:: https://bibliotekanauki.pl/articles/1039747.pdf Link otwiera się w nowym oknie
Opis:: Prebiotics are defined as selectively fermented food ingredients that induce specific changes in the composition and/or activity in the gastrointestinal microbiota beneficial to the host well-being and health. The aim of the presented experiment was to investigate the effect of a prebiotic applied alone or in combination with Hyppocastani extractum siccum, and Lini oleum virginale in rats with dimethylhydrazine induced colon cancer. Wistar albino rats were fed high fat diet supplemented with the prebiotic alone or in combination with Horse chestnut and flaxseed oil. The activity of faecal glycolytic enzymes, lipid parameters, bile acids, short chain fatty acids and counts of coliforms and lactobacilli were determined. Treatment with the prebiotic alone and in combination with selected substances significantly decreased the activity of glycolytic bacterial enzyme β-glucuronidase (P<0.001) and increased activities of β-galactosidase and β-glucosidase. Bile acids concentration was significantly decreased (P<0.01) except for the combination of the prebiotic with Horse chestnut. The prebiotic alone decreased the lipid parameters (P<0.001) and enhanced production of short chain fatty acids. Application of prebiotic and bioactive natural substances significantly reduced number of coliforms (P<0.05). Prebiotic alone significantly increased the count of lactobacilli (P<0.05). These results show that prebiotics have a protective effect and may be the useful for colon cancer prevention and treatment.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Skin microbiome friendly topical formulations containing probiotic : loaded alginate microspheres: in vitro studies
Autorzy:: Łętocha, Anna
Bielecka, Ewa
Michalczyk, Alicja
Miastkowska, Małgorzata
Kantyka, Tomasz
Sikora, Elżbieta
Opis:: Skin dysbiosis - a perturbed microbiome balance - is associated with numerous skin conditions. To manage dysbiosis, pre- and probiotics may be used as modulators to restore microbial balance. In this study, Lactobacillus casei ATCC 393-based novel probiotic formulation has been elaborated. The antimicrobial activity of L. casei against Staphylococcus epidermidis and Staphylococcus aureus was studied using kill test and well diffusion assay. The probiotic strain was found to be active against S. aureus (0.81 and 0.99 log reduction of S. aureus cells after 5 and 24 h, respectively). The well diffusion assay showed that L. casei metabolites were active against S. aureus (zone of inhibition: 5 mm). Alginate-prebiotic (tapioca flour)-encapsulated probiotic strain microspheres were used as active ingredients in a topical formulation. The safety and efficacy of this formulation was determined in vitro in human keratinocytes (HaCaT) and fibroblasts (HSF), analyzing cytotoxicity, cell proliferation rate, and proinflammatory cytokine (IL-6 and IL-8) release. In addition, the formulation+n exhibited regenerative potential in the scratch test. In vitro studies showed that the formulation containing MP reduced the survival of pathogenic strains (E. coli, S. aureus, C. albicans, C. neoformans) compared to the base formulation, devoid of lactic acid bacteria (even by 2.82 log).
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 6.

Tytuł:: Personalized vaccination? II. The role of natural microbiota in a vaccine-induced immunity
Szczepienia spersonalizowane? II. Rola naturalnej mikrobioty w indukowanej odporności poszczepiennej
Autorzy:: Dlugonska, H.
Grzybowski, M.
Tematy:: vaccination
vaccine
immunity
Microbiotidae
microorganism
immune response
probiotic
prebiotic; Pokaż więcej
Wydawca:: Polskie Towarzystwo Parazytologiczne
Powiązania:: https://bibliotekanauki.pl/articles/836484.pdf Link otwiera się w nowym oknie
Opis:: Inter-individual variation in immune response to widely used prophylactic vaccines against infectious diseases is strongly influenced by sex, MHC (Major Histocompatibility Complex), age and current hormones status of vaccinated individuals. Numerous findings showed that microorganisms residing at different sites of human or animal body (natural microbiota), especially in the gastrointestinal tract, appear to contribute to nearly every element of the host’s physiology. Recently, the microbiota is also supposed to be an underappreciated yet, but very important factor responsible for diverse vaccine efficacy observed in humans from developing vs. developed countries. In the article, selected aspects of the microbiota – host relation are presented: importance of the gut microbiota in the development of both the intestinal mucosal and systemic immune responses, bacteria of a predominant role for the immunity (e.g., SFB, Segmented Filamentous Bacteria), and several clinical observations on the varied immunogenicity of the same vaccines in different human populations. In the light of our current knowledge, manipulation of the microbiota by probiotics and/or prebiotics is becoming a realistic therapeutic and prophylactic strategy for many infectious, inflammatory and even neoplastic diseases within the gut but it may be also used for improving vaccine efficacy.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Personalized vaccination? II. The role of natural microbiota in a vaccine-induced immunity
Szczepienia spersonalizowane? II. Rola naturalnej mikrobioty w indukowanej odporności poszczepiennej
Autorzy:: Długońska, H.
Grzybowski, M.
Tematy:: vaccination
vaccine
immunity
Microbiotidae
microorganism
immune response
probiotic
prebiotic; Pokaż więcej
Wydawca:: Polskie Towarzystwo Parazytologiczne
Powiązania:: https://bibliotekanauki.pl/articles/2143340.pdf Link otwiera się w nowym oknie
Opis:: Inter-individual variation in immune response to widely used prophylactic vaccines against infectious diseases is strongly influenced by sex, MHC (Major Histocompatibility Complex), age and current hormones status of vaccinated individuals. Numerous findings showed that microorganisms residing at different sites of human or animal body (natural microbiota), especially in the gastrointestinal tract, appear to contribute to nearly every element of the host’s physiology. Recently, the microbiota is also supposed to be an underappreciated yet, but very important factor responsible for diverse vaccine efficacy observed in humans from developing vs. developed countries. In the article, selected aspects of the microbiota – host relation are presented: importance of the gut microbiota in the development of both the intestinal mucosal and systemic immune responses, bacteria of a predominant role for the immunity (e.g., SFB, Segmented Filamentous Bacteria), and several clinical observations on the varied immunogenicity of the same vaccines in different human populations. In the light of our current knowledge, manipulation of the microbiota by probiotics and/or prebiotics is becoming a realistic therapeutic and prophylactic strategy for many infectious, inflammatory and even neoplastic diseases within the gut but it may be also used for improving vaccine efficacy.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Non-racemic mixture model: a computational approach
Autorzy:: Polanco, Carlos
Buhse, Thomas
Tematy:: origin of homochirality
prebiotic peptide formation
chiral asymmetry
amino acids; Pokaż więcej
Wydawca:: Polskie Towarzystwo Biochemiczne
Powiązania:: https://bibliotekanauki.pl/articles/1038677.pdf Link otwiera się w nowym oknie
Opis:: The behavior of a slight chiral bias in favor of l-amino acids over d-amino acids was studied in an evolutionary mathematical model generating mixed chiral peptide hexamers. The simulations aimed to reproduce a very generalized prebiotic scenario involving a specified couple of amino acid enantiomers and a possible asymmetric amplification through autocatalytic peptide self-replication while forming small multimers of a defined length. Our simplified model allowed the observation of a small ascending but not conclusive tendency in the l-amino acid over the d-amino acid profile for the resulting mixed chiral hexamers in computer simulations of 100 peptide generations. This simulation was carried out by changing the chiral bias from 1% to 3%, in three stages of 15, 50 and 100 generations to observe any alteration that could mean a drastic change in behavior. So far, our simulations lead to the assumption that under the exposure of very slight non-racemic conditions, a significant bias between l- and d-amino acids, as present in our biosphere, was unlikely generated under prebiotic conditions if autocatalytic peptide self-replication was the main or the only driving force of chiral auto-amplification.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: Possible role of radon in prebiotic chemistry and in early evolution of Life on Earth
Autorzy:: Zagórski, Z. P.
Tematy:: great oxidation event
ionizing radiation
prebiotic chemistry
radon
thoron
uranium; Pokaż więcej
Wydawca:: Instytut Chemii i Techniki Jądrowej
Powiązania:: https://bibliotekanauki.pl/articles/148902.pdf Link otwiera się w nowym oknie
Opis:: Radon in the environment of early Earth was present in sites, determined by location of deposits of uranium, in very different geological formations. According to the decay of uranium-238, the total production of radon at the beginnings was twice as high as now and was continuously diminishing to the present levels. This nuclide could not play as big a role as do radioactive elements connected with the presence of high concentration of 235U, which was high enough in some places to give rise to formation of natural nuclear fission reactors (e.g. Oklo phenomenon in Africa). The main role of ionizing radiation in prebiotic chemistry and biological evolution was played by low LET (linear energy transfer) radiations, as deep penetrating sources of external energy. High LET radiations are of low penetration and could act only superficially. Radon is an exception, due to its easy transfer in the air. Therefore, it could play a role already in the cases of these early organisms which exhibited the gaseous exchange of chemical compounds with the surrounding atmosphere. The action was destructive, but, on the other hand, was also mutagenic. Nevertheless, the general quantitative effect of radon on the global scale could not be larger than of other radioactive nuclides. Presented considerations are part of the chapter by the present author on the role of nuclear and radiation chemistry in astrobiology, in the monograph published by American Scientific Publishers [1].
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: Encapsulated Mn-saturated lactoferrin as a safe source of manganese ions for restoring probiotic Lactobacillus plantarum
Autorzy:: Ściuk, Anna
Federyga, Eryk
Brindell, Małgorzata
Poznańska, Anna
Gajda-Morszewski, Przemysław
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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