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Wyszukujesz frazę "programmed cell death" wg kryterium: Temat

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Wyświetlanie 1-10 z 42
Tytuł:
Bacterial putative metacaspase structure from Geobacter sulfureducens as a template for homology modeling of type II Triticum aestivum metacaspase (TaeMCAII)
Autorzy:
Dudkiewicz, Malgorzata
Piszczek, Ewa
Tematy:
Programmed Cell Death
metacaspase
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Wydawca:
Polskie Towarzystwo Biochemiczne
Powiązania:
https://bibliotekanauki.pl/articles/1039720.pdf  Link otwiera się w nowym oknie
Opis:
Metacaspases, cysteine proteases belonging to the peptidase C14 family, are suspected of being involved in the programmed cell death of plants, although their sequences and substrate specificity differ from those of animal caspases. At present, the knowledge on the metacaspase reaction mechanism is based only on biochemical data and homology models constructed on caspase templates. Here we propose a novel template for metacaspase modeling and demonstrate important advantages in comparison to the conventionally used caspase templates. We also point out the connection between plant and bacterial metacaspases, underlining the prokaryotic roots of Programmed Cell Death (PCD).
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modulation of ERK1/2 activity is crucial for sphingosine-induced death of glioma C6 cells
Autorzy:
Krzemiński, Patryk
Tematy:
glioma C6
ERK1/2
cytoskeleton
programmed cell death
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Wydawca:
Polskie Towarzystwo Biochemiczne
Powiązania:
https://bibliotekanauki.pl/articles/1041346.pdf  Link otwiera się w nowym oknie
Opis:
In this study the contribution of the ERK1/2 pathway to sphingosine-induced death and morphological changes of the actin cytoskeleton in glioma C6 cells was investigated. Surprisingly, the level of ERK1/2 phosphorylation does not change after incubation of cells with sphingosine. Despite this, sphingosine induces rounding and detachment of cells without formation of apoptotic bodies. To shed light on this process, a specific inhibitor of ERK1/2 phosphorylation, U0126, was used. Cells incubated simultaneously with sphingosine and U0126 not only detached, but also exhibited formation of apoptotic-like blebs. These data suggest that during sphingosine-induced glioma C6 cell death apoptotic blebbing is dependent on ERK1/2 signalling and occurs only when ERK1/2 activity is decreased or abolished.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Apoptoza w jajniku.
Apoptosis in the ovary.
Autorzy:
Natkaniec, Weronika
Opis:
Śmierć komórki została opisana po raz pierwszy przez Waltera Flemminga, który początkowo nazwał ten fenomen „chromatolizą”. Po latach badań i obserwacji tego zjawiska zostało ono nazwane- apoptozą. Obecnie naukowcy są zgodni co do natury oraz mechanizmu procesu jakim jest zaprogramowana śmierć komórki. Mimo, że apoptoza jest zjawiskiem powszechnym w naszym organizmie, nie we wszystkich strukturach jest tak dobrze widoczna jak w jajniku. Z uwagi na to iż jajnik jest narządem, w którym bardzo duża liczba komórek ulega degradacji zarówno w życiu prenatalnym jak i postnatalnym to właśnie w gonadzie żeńskiej proces ten jest najlepiej widoczny. W związku z tym, że zaprogramowana śmierć komórki jest kontrolowana przez szereg czynników i związków chemicznych i odgrywa ważną role w różnicowaniu się organizmów wielokomórkowych, tak ważnym jest aby w pełni zrozumieć ten proces.
Cell death was first described by Walter Flemming who at first called this phenomenon “chromatolysis”. After years of research and observation of this process, it has been termed apoptosis. Nowadays, scientists are in agreement about the nature and mechanism which runs programmed cell death. Although apoptosis is fairly common in our system is not all structures are easy to observe. In view of the fact that the ovary is a structure in which a large number of cells are eliminated during both, prenatal and postnatal life, it is in the female gonads, apoptosis is the most visible. Due to the fact that apoptosis is controlled by a number of compounds and plays an important role in the differentiation of multicellular organisms is so important to accurate understanding of this process.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Inne
Tytuł:
Polyadenylation and decay of 26S rRNA as part of Nicotiana tabacum response to cadmium
Autorzy:
Lewandowska, Małgorzata
Borcz, Barbara
Kamińska, Jolanta
Wawrzyński, Adam
Sirko, Agnieszka
Tematy:
polyadenylation of rRNA
RNA decay
programmed cell death
cadmium
tobacco
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Wydawca:
Polskie Towarzystwo Biochemiczne
Powiązania:
https://bibliotekanauki.pl/articles/1040862.pdf  Link otwiera się w nowym oknie
Opis:
In contrast to mRNAs, ribosomal RNAs are generally not considered to be polyadenylated. Only a few recent reports describe non-abundant polyadenylated rRNA-related transcripts that have been detected and characterized in yeast and in human cells. Here we depict the phenomenon of 26S rRNA polyadenylation and degradation that was observed in shoots of Nicotiana tabaccum plants grown in the presence of cadmium. Fragments corresponding to 26S rRNA were identified using suppression subtractive hybridization during screening for genes induced in tobacco plants upon a three-week exposure to 15 µM cadmium chloride. Extracts prepared from the above-ground tissues of cadmium-treated tobacco plants were supposed to contain exclusively polyadenylated mRNAs. Surprisingly, numerous polyadenylated fragments matching parts of 26S rRNA were identified and their presence was confirmed by Northern blot and cDNA amplification techniques. To our knowledge this is the first report on rRNA polyadenylation in plants.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Strefa twardzieli w drewnie i proces jej powstawania
Heartwood zone and its formation process
Autorzy:
Bieniasz, A.
Tulik, M.
Tematy:
parenchyma cells
programmed cell death
sapwood
tyloses
aspiration
ecstracts
heartwood formation
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Wydawca:
Polskie Towarzystwo Leśne
Powiązania:
https://bibliotekanauki.pl/articles/979188.pdf  Link otwiera się w nowym oknie
Opis:
This paper reviews the literature on heartwood and its formation process. The factors involved in the process of heartwood formation are described, with particular attention paid to molecular, intercellular, organismal and environmental ones. The spatial distribution of heartwood along longitudinal and radial axes of the stem as well as biochemical changes in the heartwood and durability of this zone are also presented. Based on the literature data, it turns out that the heart−wood formation is neither clearly studied, nor fully understood. It seems that this part of wood can not only play a significant role from the point of view of tree biomechanics, but also is of great importance in their immune responses. In the era of observed dying processes of forest−forming trees, knowledge about the role of heartwood in these responses seems desirable.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Unraveling the non-senescence phenomenon in Hydra
Autorzy:
Dańko, Maciej
Kozłowski, Jan
Schaible, Ralf
Opis:
Unlike other metazoans, Hydra does not experience the distinctive rise in mortality with age known as senescence, which results from an increasing imbalance between cell damage and cell repair. We propose that the Hydra controls damage accumulation mainly through damage-dependent cell selection and cell sloughing. We examine our hypothesis with a model that combines cellular damage with stem cell renewal, differentiation, and elimination. The Hydra individual can be seen as a large single pool of three types of stem cells with some features of differentiated cells. This large stem cell community prevents “cellular damage drift,” which is inevitable in complex conglomerate (differentiated) metazoans with numerous and generally isolated pools of stem cells. The process of cellular damage drift is based on changes in the distribution of damage among cells due to random events, and is thus similar to Muller׳s ratchet in asexual populations. Events in the model that are sources of randomness include budding, cellular death, and cellular damage and repair. Our results suggest that non-senescence is possible only in simple Hydra-like organisms which have a high proportion and number of stem cells, continuous cell divisions, an effective cell selection mechanism, and stem cells with the ability to undertake some roles of differentiated cells.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
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