Temat: proton therapy - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Bragg peak position monitoring using silicon and titanium nanoparticles as prompt-gamma tracers
Autorzy:: Magiera, Andrzej
Garbacz, Magdalena
Kołodziej, Barbara
Beus, Barbara
Klębowski, Bartosz
Kasper, Jonas
Kaszlikowska, Aleksandra
Wrońska, Aleksandra
Hetzel, Ronja
Opis:: Purpose: Spherical silicon and rods-like titanium oxide nanoparticles (NPs) have been analyzed for use in the proton range verification method in proton therapy (main goal), as well as radiosensitizers (second goal) in this therapy due to their physical and biological properties. The method involved the use of tracers emitting prompt-gamma radiation during irradiation with protons. The basic assumption of the method is to selectively deliver the tracer in form of NPs to the tumor. The cytotoxicity of the obtained nanomaterials was also checked against normal and cancer cells. Methods and Materials: Correlation between the Bragg peak (BP) position in the PMMA phantom and the signal emitted by the analyzed tracers were determined on the basis of simulations carried out using the Geant4 toolkit. To determine the cytotoxicity of nanosilicone and nanotitanium, as well as their radiosensitizing properties a classic MTS test and a modified multiple MTS test were performed. The location of both types of NPs was determined using holotomographic microscopy. Results: For silicon NPs, a signal was observed when the BP was located entirely in the structure imitating a tumor and decreased when the BP was entirely outside the structure. In the case of titanium NPs, the signal did not correlate with the position of the structure mimicking a tumor. Both types of NPs at low concentrations turned out to be non-toxic to both cell lines. It has been shown that both types of nanoparticles have promising radiosensitizing properties, in particular towards cancer cells. Conclusions: When it comes to physical properties, silicon appears to be an optimal candidate for use in proton therapy monitoring. Moreover, the silica NPs turned out to be slightly more effective radiosensitizers than titanium NPs.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 2.

Tytuł:: Ambient dose equivalent measurements in secondary radiation fi elds at proton therapy facility CCB IFJ PAN in Krakow using recombination chambers
Autorzy:: Jakubowska, E. A.
Gryziński, M. A.
Golnik, N.
Tulik, P.
Stolarczyk, L.
Horwacik, T.
Zbroja, K.
Góra, Ł.
Tematy:: recombination chambers
workplace monitoring
proton therapy; Pokaż więcej
Wydawca:: Instytut Chemii i Techniki Jądrowej
Powiązania:: https://bibliotekanauki.pl/articles/147396.pdf Link otwiera się w nowym oknie
Opis:: This work presents recombination methods used for secondary radiation measurements at the Facility for Proton Radiotherapy of Eye Cancer at the Institute for Nuclear Physics, IFJ, in Krakow (Poland). The measurements of H*(10) were performed, with REM-2 tissue equivalent chamber in two halls of cyclotrons AIC-144 and Proteus C-235 and in the corridors close to treatment rooms. The measurements were completed by determination of gamma radiation component, using a hydrogen-free recombination chamber. The results were compared with the measurements using rem meter types FHT 762 (WENDI-II) and NM2 FHT 192 gamma probe and with stationary dosimetric system.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Sex differences in the treatment of uveal melanoma in a group of 1336 patients
Autorzy:: Dębicka-Kumela, Magdalena
Romanowska-Dixon, Bożena
Nowak, Michał Szymon
Śmigielski, Janusz
Opis:: (1) Background: The aim of this study was to analyze the sex differences in the treatment of uveal melanoma (UM) in a group of 1336 patients from a national referral center during the period 2018–2021. (2) Materials and Methods: The study was designed in a retrospective manner. A total of 1336 patients who were newly diagnosed with UM at the Department of Ophthalmology and Ophthalmic Oncology, Jagiellonian University Collegium Medicum, Krakow, Poland, between 1 January 2018 and 31 December 2021, were included in the study. The demographic and clinical data were compiled, including the sex of patients and the treatment methods. (3) Results: In total, 1336 patients with ocular melanoma were identified, including 726 women (54.34%) and 610 men (45.66%). A total of 49.70% of tumors were localized in the right eye and 50.30% in the left eye. UMs were localized statistically significantly more frequently posterior to the equator of the eye globe in men than in women (79.67% vs. 74.10%, Chi^2 Pearson test p = 0.035). Tumors tended to be larger in men, but this difference was not clinically significant. Men were enucleated more often than women (23.44% vs. 18.04%, Chi^2 Pearson test p = 0.015). (4) Conclusions: Statistically significant sex differences were found in the treatment of uveal melanoma in a national referral center in Poland, with men being enucleated more often than women.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 4.

Tytuł:: Status report of the LNS Superconducting Cyclotron
Autorzy:: Rifuggiato, D.
Calabretta, L.
Cuttone, G.
Tematy:: cyclotron
axial injection
electrostatic deflectors
proton therapy; Pokaż więcej
Wydawca:: Instytut Chemii i Techniki Jądrowej
Powiązania:: https://bibliotekanauki.pl/articles/146187.pdf Link otwiera się w nowym oknie
Opis:: The LNS Superconducting Cyclotron has been working in stand alone mode since the beginning of 2000, after 5 years of operation as a booster of the 15 MV Tandem. The new mode has proven to be by far more advantageous than the previous one from the point of view of operation. Working with axial injection, a quite high number of new beam types has been developed. The new mode allows for acceleration of H2 + molecules, which break into two protons when crossing a stripper in the beam line out of the cyclotron. 62 MeV protons have been used for radiotherapy since February 2002. The new mode allows to inject a more intense beam as compared to the previous mode. Therefore, an upgrading program of the cyclotron has started, aiming at having an intense extracted beam to be used as a primary beam in a facility for production of radioactive beams. Beam tests have been accomplished to evaluate transmission figures, while the upgrading of the present electrostatic deflectors has started: new deflector systems, able to dissipate high beam power and allowing for easier maintenance, have been designed and will soon be tested in the machine.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Influence of the energy spectrum and spatial spread of proton beams used in eye tumor treatment on the depth-dose characteristics
Autorzy:: Konefał, A.
Szaflik, P.
Zipper, W.
Tematy:: Bragg peak
proton therapy
Monte Carlo calculations; Pokaż więcej
Wydawca:: Instytut Chemii i Techniki Jądrowej
Powiązania:: https://bibliotekanauki.pl/articles/148640.pdf Link otwiera się w nowym oknie
Opis:: The influence of the energy spectrum and the spatial spread of a therapeutic proton beam impinging on an irradiated medium (called the entrance beam) on the depth-dose characteristics in water, in the proton energy range of 50 division sign 70 MeV was studied. It turns out that full width at half maximum (FWHM) of the Bragg peak increases almost linearly with increasing proton energy. It ranges from 1.53 mm for 50 MeV to 2.59 mm for 70 MeV, for monoenergetic protons. Moreover, the significant influence of the energy spread of the entrance proton beam on the intensity and FWHM of the Bragg peak is visible. FWHM of the Bragg peak of 60 MeV protons is equal to 2.03, 3.37 and 5.86 mm for a monoenergetic beam and beams with an energy spread of 0.5 and 1 MeV SD (standard deviation), respectively. The intensity of the Bragg peak of a 60 MeV proton beam with an energy spread of 1 MeV SD is approximately 25% less than that for a monoenergetic beam. Moreover, the Bragg peak shifts to smaller depths as the energy spread of the entrance beam increases. The shift of the peak is about 0.2÷0.3 mm for a beam with an energy spread of 0.5 MeV SD and between 0.4 division sign 0.5 mm for an energy spread of 1 MeV SD, compared with a monoenergetic beam in the energy range from 50 to 60 MeV. However, the spatial spread of the entrance proton beam does not affect significantly the depth-dose characteristic.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Spectroscopic study of prompt-gamma emission for range verification in proton therapy
Autorzy:: Kelleter, Laurent
Magiera, Andrzej
Tessonnier, Thomas
Laihem, Karim
Rusiecka, Katarzyna
Konefał, Adam
Leidner, Johannes
Parodi, Katia
Besuglow, Judith
Stahl, Achim
Wrońska, Aleksandra
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 7.

Tytuł:: Assessment of exposure to X - rays during patient positioning at the proton eye radiotherapy facility at IFJ PAN, Kraków
Autorzy:: Adamczyk, D.
Dulny, B.
Horwacik, T.
Swakoń, J.
Olko, P.
Tematy:: eye proton therapy
exposure assessment
patient positioning; Pokaż więcej
Wydawca:: Instytut Chemii i Techniki Jądrowej
Powiązania:: https://bibliotekanauki.pl/articles/147898.pdf Link otwiera się w nowym oknie
Opis:: At the Institute of Nuclear Physics of the Polish Academy of Sciences (IFJ PAN, Kraków, Poland) the proton eye radiotherapy facility has recently been developed and is now fully operational. A set of two X-ay RAD-14 Varian medical systems tubes are used to obtain orthogonal images of the patient’s eyeball undergoing radiotherapy with tantalum clips already attached to its surface to delineate the tumour volume. We assessed the dose received by the patient from multiple X-ray exposures during the patient positioning procedure. Measurements of Kair were performed using various types of ionization chambers and MCP-N thermoluminescent (TL) detectors and calculated using the PCXMC code. Good agreement between measurements and calculations was found. The mean absorbed dose to the brain was measured using TL detectors placed inside the head of a Rando anthropomorphic phantom used in simulation of the patient positioning procedure. The measured maximum incident air kerma absorbed during the entire procedure of patient positioning was found not to exceed 7 mGy, while the mean absorbed dose to the brain did not exceed 2 mSv.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Evidence for external beam radiotherapy in mediastinal Hodgkin and non-Hodgkin lymphoma – systematic review
Autorzy:: Kowalska, Malwina
Siwiec, Jacek
Jaros, Klaudia
Sitarz-Kilian, Ewelina
Moćko, Paweł
Koperny, Magdalena
Kawalec, Paweł
Opis:: Introduction and objective: Proton beam therapy (PBT) provides the opportunity for a more localized delivery of high energy protons and may reduce the damage to healthy tissues and vital organs. The aim of this review was to assess the effects of proton therapy for patients diagnosed with Hodgkin or non-Hodgkin lymphoma treated with mediastinal irradiation. Review methods: A systematic search of EMBASE, MEDLINE via OVID and Cochrane Library was conducted in May 2022 according to PRISMA guidelines to identify relevant data on the efficacy and toxicity of proton beam therapy for patients diagnosed with Hodgkin or non-Hodgkin lymphoma. Brief description of the state of knowledge: Of 566 screened abstracts (430 after de-duplication) 11 studies with a total of 529 patients were included. All studies were case series published between 2011–2021. Median range of follow-up time was 15–63.6 months. The overall survival (OS) for 2 years varied from 91% – 98% for 5 of the included studies. Three of the included studies had favourable outcomes with 2-year progression-free survival (PFS) ranging from 73% – 94%. Skin reaction, oesophagitis and fatigue were found to be the most common grade 1 and grade 2 toxicities. No acute or late grade 4 and higher toxicities/adverse events were observed. Summary: There are data indicating that PBT may to be an effective treatment against mediastinal Hodgkin and non-Hodgkin lymphoma. Because all the studies were case series, the authors of this review have little confidence in the evidence. There remains a need for well-designed randomized controlled trials to inform about the optimal approach to proton irradiation in HL and NHL.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 9.

Tytuł:: Near-field coded-mask technique and its potential for proton therapy monitoring
Autorzy:: Magiera, Andrzej
Mueller, Florian
Schulz, Volkmar
Weissler, Bjoern
Urbanevych, Vitalii
Wong, Ming Liang
Stahl, Achim
Kasper, Jonas
Müller, Sara
Hetzel, Ronja
Rafecas, Magdalena
Kołodziej, Magdalena
Wrońska, Aleksandra
Schug, David
Bolke, Andreas
Rusiecka, Katarzyna
Kercz, Monika
Opis:: Objective. Prompt-gamma imaging encompasses several approaches to the online monitoring of the beam range or deposited dose distribution in proton therapy. We test one of the imaging techniques - a coded mask approach - both experimentally and via simulations. Approach. Two imaging setups have been investigated experimentally. Each of them comprised a structured tungsten collimator in the form of a modified uniformly redundant array mask and a LYSO:Ce scintillation detector of fine granularity. The setups differed in detector dimensions and operation mode (1D or 2D imaging). A series of measurements with radioactive sources have been conducted, testing the performance of the setups for near-field gamma imaging. Additionally, Monte Carlo simulations of a larger setup of the same type were conducted, investigating its performance with a realistic gamma source distribution occurring during proton therapy. Main results. The images of point-like sources reconstructed from two small-scale prototypes' data using the maximum-likelihood expectation maximisation algorithm constitute the experimental proof of principle for the near-field coded-mask imaging modality, both in the 1D and the 2D mode. Their precision allowed us to calibrate out certain systematic offsets appearing due to the limited alignment accuracy of setup elements. The simulation of the full-scale setup yielded a mean distal falloff retrieval precision of 0.72 mm in the studies for beam energy range 89.5–107.9 MeV and with 1 × 10$^{8}$ protons (a typical number for distal spots). The implemented algorithm of image reconstruction is relatively fast—a typical procedure needs several seconds. Significance. Coded-mask imaging appears a valid option for proton therapy monitoring. The results of simulations let us conclude that the proposed full-scale setup is competitive with the knife-edge-shaped and the multi-parallel slit cameras investigated by other groups.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 10.

Tytuł:: First experimental test of a coded-mask gamma camera for proton therapy monitoring
Autorzy:: Kercz, Monika
Mielke, Linn
Roser, Jorge
Urbanevych, Vitalii
Ostrzołek, Gabriel
Kołodziej, Magdalena
Rafecas, Magdalena
Fenger, Alexander
Rusiecka, Katarzyna
Kołodziej, Barbara
Kasper, Jonas
Wong, Ming-Liang
Wrońska, Aleksandra
Farah, George N.
Dubiel, Mikołaj
Brons, Stephan
Stahl, Achim
Hetzel, Ronja
Opis:: Objective. The objective of the presented study was to evaluate the feasibility of a coded-mask (CM) gamma camera for real-time range verification in proton therapy, addressing the need for a precise and efficient method of treatment monitoring. Approach. A CM gamma camera prototype was tested in clinical conditions. The setup incorporated a scintillator-based detection system and a structured tungsten collimator. The experiment consisted of the irradiation of PMMA phantom with proton beams of energies ranging from 70.51 to 108.15 MeV. Experimental data were benchmarked against Monte Carlo simulations. The distal falloff position (DFP) was determined for both experimental data and simulations. Main results. The tested CM camera achieved a statistical precision of DFP determination of 1.7 mm for 108 protons, which is consistent with simulation predictions, despite hardware limitations such as non-functional detector pixels. Simulations indicated that a fully operational setup would further improve the performance of the detector. The system demonstrated rate capability sufficient for clinical proton beam intensities and maintained performance without significant dead time. Significance. This study validates the potential of the CM gamma camera for real-time proton therapy monitoring. The technology promises to enhance treatment accuracy and patient safety, offering a competitive alternative to existing approaches such as single-slit and multi-slit systems.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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