Temat: release kinetics - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Encapsulation of l-menthol in hydroxypropyl-β-cyclodextrin and release characteristics of the inclusion complex
Autorzy:: Zhu, G.
Xiao, Z.
Zhou, R.
Niu, Y.
Tematy:: l-menthol
inclusion complex
release characteristics
binding energy
release kinetics; Pokaż więcej
Wydawca:: Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Powiązania:: https://bibliotekanauki.pl/articles/778623.pdf Link otwiera się w nowym oknie
Opis:: l-menthol has been widely used in flavour, food and pharmaceuticals. Because of its high volatility and whisker growth, l-menthol-hydroxypropyl-β-cyclodextrin inclusion complex was produced to improve shelf-life, provide protection, and enhance the stability of l-menthol. The inclusion complex was characterized by Fourier transform infrared spectroscopy, X-ray diffraction. The results show that l-menthol was successfully encapsulated in hydroxypropyl-β-cyclodextrin. l-menthol loading capacity is about 8.44%. Geometries and binding energies of l-menthol-hydroxypropyl-β-cyclodextrin inclusion complexes were investigated using molecular mechanics calculations. The shape and orientation of the most stable complex, and the minimum binding energy were determined. L-menthol release from complex was determined by thermogravimetric analysis. Two l-menthol release rate peaks were observed at 69.3 and 279.1°C. The l-menthol release reaction order, release activation energy and the preexponential factor were obtained.
Dostawca treści:: Biblioteka Nauki

Artykuł

na półce

Skocz do pozycji: 2.

Tytuł:: Evaluation of the effect of formulation composition and physicochemical properties of omeprazole and bisoprolol hemifumarate on electrospun nanofibers characteristics
Autorzy:: Brniak, Witold
Łyszczarz, Ewelina
Majda, Dorota
Mendyk, Aleksander
Srebro, Justyna
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Artykuł

na półce

Skocz do pozycji: 3.

Tytuł:: Chitosan/poly(vinyl alcohol) hydrogels as controlled drug delivery systems
Autorzy:: Kocemba, Aleksandra
Mucha, Maria
Tematy:: chitosan/PVA hydrogel
gentamicin
glutaraldehyde
release kinetics
swelling; Pokaż więcej
Wydawca:: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Powiązania:: https://bibliotekanauki.pl/articles/1034608.pdf Link otwiera się w nowym oknie
Opis:: In order to achieve hydrogel and drug release profiles, a comprehensive knowledge of the types, properties and syntheses of hydrogel polymer networks are needed. For this reason, a natural biopolymer hydrogel based on chitosan was described. Chitosan has many advantages, which meet the requirements necessary for the preparation of medical materials; for example, wound dressings. This article focused on the biomedical use of a chitosan hydrogel: chitosan–poly(vinyl alcohol) (PVA). The method of preparation of hydrogels containing a drug as an active wound dressing was described. To obtain a hydrogel dressing to be applied in patients with burns or difficult curative wounds, gentamicin (an aminoglycoside antibiotic) was used as a medicament. The effect of the PVA concentration in hydrogels on the release rate of the antibiotic was examined. For this, the crosslinking agent of the hydrogel, glutaraldehyde, was used. The release process of gentamicin was described by using an equation of first order kinetics.
Dostawca treści:: Biblioteka Nauki

Artykuł

na półce

Skocz do pozycji: 4.

Tytuł:: FORMULATION AND IN VITRO EVALUATION OF FLOATING TABLETS OF PSYLLIUM HUSK & TRAGACANTH USING SITAGLIPTIN PHOSPHATE AS A MODEL DRUG
Autorzy:: Ghumman, Shazia A.
Andleeb, Sahrish
Bashir, Sajid
Muhammad, Sarfraz R.
Badshah, Munair
Khattak, Majeedullah
Tematy:: sustained release
Release kinetics
Tragacanth
floating tablets
Sitagliptin phosphate
psyllium husk; Pokaż więcej
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Powiązania:: https://bibliotekanauki.pl/articles/895403.pdf Link otwiera się w nowym oknie
Opis:: Abstract A novel floating controlled release drug delivery system of Sitagliptin phosphate was formulated in an effort to increase the gastric retention time of the dosage form and thereby increased drug bioavailability. The tablets were prepared by wet granulation method using Psyllium Husk and tragacanth gum as a release retarding polymers and sodium bicarbonate as a gas generating agent. All the designed nine batches of floating tablets were evaluated for physical characteristics viz. weight variation, thickness, content uniformity, hardness, floating capacity, swelling studies. All formulations had floating lag time of less than 1 min and constantly floated for 12 h except F1, F4 and F7 (that dissolved completely in 8 h or less than 8 h). In vitro drug release studies were carried out for 8 h and release mechanism was further evaluated by linear regression analysis, F9 composed of 30% Psyllium Husk, 10% tragacanth gum and 18% sodium bicarbonate sustained the drug release for longer period. The formulations followed first order kinetics, Higuchi drug release kinetics with diffusion as the dominant mechanism of drug release and the release exponent ranged (0.452-0.635) indicating that the drug release from all formulations was by non-Fickian diffusion mechanism. The prepared floating tablets of STP (F9) might be a promising drug delivery system with sustained release action and improved bioavailability.
Dostawca treści:: Biblioteka Nauki

Artykuł

na półce

Skocz do pozycji: 5.

Tytuł:: Sugar Palm Starch/Chitosan Bionanocomposite Films Incorporated with Anthocyanin and Curcumin – Thermal Properties and Release Kinetics
Autorzy:: Rachmina, Rachmina
Hasan, Muhammad
Hasanah, Uswatun
Halim, Abdul
Tematy:: release kinetics
anthocyanin
curcumin
bionanocomposite film
sugar palm starch
chitosan; Pokaż więcej
Wydawca:: Polskie Towarzystwo Inżynierii Ekologicznej
Powiązania:: https://bibliotekanauki.pl/articles/59114271.pdf Link otwiera się w nowym oknie
Opis:: The packaging industry responding to growing consumer demands for product safety, seeks active packaging that allows controlled antioxidant release through incorporating anthocyanin, curcumin, cinnamaldehyde, and other polyphenolic compounds to enhance functional properties of the film antimicrobial interfacial interaction. The research focuses on exploring the impact of adding curcumin and anthocyanin to sugar palm starch/chitosan bionanocomposite films, specifically examining the release kinetics of these bioactive compounds. The biocomposite film with added curcumin exhibits a smoother surface compared to the anthocyanin-based film. Although the thermal stability of the CH/SPS matrix remains unaffected by the addition of anthocyanin and curcumin, the inclusion of these compounds significantly reduces the melting enthalpy of the CH/SPS matrix. Specifically, the addition of curcumin decreases it from 142.96 J/g to 23.43 J/g, and the addition of anthocyanin reduces it to 33.22 J/g. Anthocyanin release from the CH/SPS matrix into water conforms to the Kosmeye-Peppas model (R2 = 0.9808, n = 0.1177), while the release kinetics of curcumin compounds adhere to the Higuchi model (R2 = 0.9968). These findings provide advantageous insights that potentially have implications for a variety of applications, particularly in areas such as sustainable food packaging.
Dostawca treści:: Biblioteka Nauki

Artykuł

na półce

Skocz do pozycji: 6.

Tytuł:: BOX BEHNKEN DESIGN: A STATISTICAL APPROACH TO EVALUATE THE EFFECT OF CROSSLINKED CARBOXYMETHYL CELLULOSE AND SODIUM STARCH GLYCOLATE ON RELEASE KINETICS OF DRUG
Autorzy:: Hanif, Muhammad
Abbas, Ghulam
Rasul, Akhtar
Khan, Sajid M.
Amir, Muhammad N.
Tematy:: FTIR
XRD
DSC
quality by design
domperidone maleate
drug release kinetics; Pokaż więcej
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Powiązania:: https://bibliotekanauki.pl/articles/895395.pdf Link otwiera się w nowym oknie
Opis:: The aim of study was to evaluate the release kinetics of domperidone maleate (DM) from immediate release (IR) tablets prepared by wet granulation method. Box behnken design (BBD) was used to optimize and evaluate the main, interaction and quadratic effects of independent variables i.e. crosslinked carboxymethyl cellulose (CMC) (X1), sodium starch glycolate (SSG) (X2) and starch (X3) on responses R2 of first order (YI) and β value of weibull model (Y2). Prepared tablets were characterized by various physical tests, in-vitro drug release, fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD) and differential scanning calorimetry (DSC). Accelerated stabilities studies were performed on optimized formulation D9. Y1 and Y2 were ranged from 0.9959 to 0.9994 and 0.041 to 0.912 respectively. β value of weibull model indicated the parabolic shape of dissolution curve. The quadratic model fit the data well and the resulting equations were used to predict the responses in the box behnken design. FTIR spectra showed the compatibility of DM with CMC and SSG. XRD presented diffraction lines indicates crystalline nature of drug. DSC thermograms indicated endothermic peak at 220 0C for DM. Stabilities studies revealed that no significant change in hardness, friability, disintegration time and dissolution release profile of DM. It is concluded that a combination of CMC and SSG can be used to enhance the dissolution and release kinetics of IR tablets of DM.
Dostawca treści:: Biblioteka Nauki

Artykuł

na półce

Skocz do pozycji: 7.

Tytuł:: Release of selected nutrients from polymer-coated fertilisers in the soil environment
Autorzy:: Włodarczyk, Małgorzata
Siwek, Hanna
Lubkowski, Krzysztof
Buchwał, Anna
Tematy:: biodegradable polymer-coated fertiliser
diffusion coefficient
nutrients
release kinetics
soil leachate; Pokaż więcej
Wydawca:: Instytut Technologiczno-Przyrodniczy
Powiązania:: https://bibliotekanauki.pl/articles/58907020.pdf Link otwiera się w nowym oknie
Opis:: The aim of the study was to evaluate the release of NH4-N and PO4-P from polymer-coated fertilisers in the soil environment, and to analyse their impact on pH and conductivity of the soil leachates. In this investigation mineral NPK(S) 6-20-30(7) fertiliser (as a starting material), commercial, controlled-release OsmocoteTM fertiliser (as a reference material) and four polymer-coated fertilisers have been used. Biodegradable polybutylene(succinate-co-dilinoleate), polyethylene(succinate-co-terepftalate) and chitosan have been used as coating materials. The experiments were conducted in the laboratory conditions, in PVC columns filled with air-dry soil. The nutrients release from the investigated materials was explained based on the diffusion mechanism and it was interpreted with the use of the Korsmeyer-Peppas kinetic model. Two mechanisms dominate in the release process of nutrients: the mechanism based on quasi-Fickian diffusion and non-Fickian (anomalous case) mechanism. The largest changes of pH and electrical conductivity (EC) of soil leachates occurred in the initial period of research for all tested fertilisers (pH: 9.5-20.3% - loamy sand (S1) 7.9-20.6% – sandy loam (S2); EC: 438-1667% - S1, 771-1509% - S2). The polymer coating significantly reduces the nutrient release from the fertiliser core. The size of these changes depends on the type and thickness of the polymer layer and the physicochemical properties of the soils.
Dostawca treści:: Biblioteka Nauki

Artykuł

na półce

Skocz do pozycji: 8.

Tytuł:: Emulsions as vehicles for the controlled release of astaxanthin in topical application
Autorzy:: Dymek, Michał
Sikora, Elżbieta
Tematy:: astaxanthin
release kinetics
skin delivery systems
emulsions
antioxidant activity
astaksantyna
kinetyka uwalniania
emulsja
aktywność antyoksydacyjna; Pokaż więcej
Wydawca:: Polska Akademia Nauk. Czasopisma i Monografie PAN
Powiązania:: https://bibliotekanauki.pl/articles/2086812.pdf Link otwiera się w nowym oknie
Opis:: In the work, the antioxidant activity of astaxanthin (AST) and the influence of the base formulation on the kinetics of AST release were studied. Three stable O/W AST-loaded emulsions, differing in droplet size (12.7 m(E1), 3.8 m(E2), 3.2 m(E3)) and a nanoemulsion (0.13 m, NE) were prepared. The results confirmed very strong antioxidant activity of AST. The emulsion internal phase droplet size did not significantly affect the AST release. The amount of released AST was respectively: 13.60% (E1), 11.42% (E2), 9.45% (E3), 9.71% (NE). The best fit to experimental data was obtained using the Higuchi model for emulsions and the Korsmeyer-Peppas model for NE. The results show that the AST release process is limited by the diffusion through carriers and the prepared O/W emulsions can be applied as vehicles for delivery of astaxanthin to the skin, ensuring effective anti-aging action of the cosmetics.
Dostawca treści:: Biblioteka Nauki

Artykuł

na półce

Skocz do pozycji: 9.

Tytuł:: Analysis of model drug release kinetics from complex matrices of polylactide-chitosan
Autorzy:: Balcerzak, Jacek
Mucha, Maria
Tematy:: chitosan
kinetics
polylactide
polymer composite
prolonged release; Pokaż więcej
Wydawca:: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Powiązania:: https://bibliotekanauki.pl/articles/1035492.pdf Link otwiera się w nowym oknie
Opis:: In the present paper the Authors analyse the experimental results of a model drug (ibuprofen) release approximated with three commonly used semi-empirical models: Korsmeyer-Peppas, first order kinetics and Gallagher-Corrigan equation. Drug carriers in the form of films composed of chitosan matrix and polylactide microparticles were produced by ultrasonic emulsification with solvent evaporation followed by film casting technique. Additionally, polylactide shield layers (5μm thick) were attached to both sides of obtained films by means of spray-coating process. A microscopic analysis confirmed the uniform distribution of polylactide microparticles (diameter: 1-2 μm) within chitosan films. Based on the of microscopic study, molecular drug dispersion within composite matrices was found. Fraction of ibuprofen released into medium of pH equal to 1.4 or 7.2 (GI tract) was measured by means of UV-VIS spectrophotometry. The finest approximation was obtained by fitting two-stage release model derived by K. M. Gallagher and O. I. Corrigan to the release data. Analysis of model parameters led to the conclusion that the increase of composite films thickness as well as weight fraction of PLA microparticles within films prolong drug release.
Dostawca treści:: Biblioteka Nauki

Artykuł

na półce

Skocz do pozycji: 10.

Tytuł:: Kinetics of active substance release from flat biopolymer multilayer films
Autorzy:: Michalak, Iwona
Traczyk, Dariusz
Mucha, Maria
Tematy:: chitosan
drug release
polylactid
polymer films
swelling kinetics; Pokaż więcej
Wydawca:: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Powiązania:: https://bibliotekanauki.pl/articles/1035524.pdf Link otwiera się w nowym oknie
Opis:: Abstract. Polymer films were made of different biodegradable materials. Solid support of model active substance (salicylic acid) was unmodified and modified (crosslinked with glutaraldehyde) chitosan and outside layers were polylactid acid (PLA). The aim of the study was to obtain the controlled release kinetics of active substance, in medium of pH 5.6 which is similar to conditions occurring on the human skin surface. The chitosan films were investigated with swelling kinetics while multilayer films were studied with release kinetics of active substance (salicylic acid). The amount of salicylic acid released from film was measured using a UV-VIS spectrophotometer. The appropriate mathematical model was also adjusted to the experimental points. The results prove that the swelling process follows the first order kinetics but the results of release process are fitted with Peppas model.
Dostawca treści:: Biblioteka Nauki

Artykuł

na półce

Informacja

Wyszukujesz frazę "release kinetics" wg kryterium: Temat