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Wyświetlanie 1-10 z 18
Tytuł:
Renal assessment in teenage patients with cystic fibrosis – preliminary report
Ocena funkcji nerek u nastolatków z mukowiscydozą – doniesienie wstępne
Autorzy:
Sands, Dorota
Jaworska, Joanna
Ozimek, Małgorzata
Urzykowska, Agnieszka
Tematy:
CF
renal function
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Wydawca:
Wydawnictwo ALUNA
Powiązania:
https://bibliotekanauki.pl/articles/1032962.pdf  Link otwiera się w nowym oknie
Opis:
Background: Together with increasing life expectancy of patients with cystic fibrosis (CF), there is a growing need to deal with unforeseen problems and complications. Among others renal dysfunction has become of great concern. Aim: Evaluation of renal function in CF children. Material and methods: We performed cross-sectional study on a group of 11 teenage inpatients with CF. Physical examination, past medical history analysis, renal function measurements and analysis were conducted in all of them. Renal assessment included: serum cystatin C and creatinine levels, measured and estimated creatinine clearance, estimated cystatin C clearance, urine indicators of crystallization risk and renal ultrasonography. Results: One patient had elevated serum cystatin C level and diminished McIsaac equation. Renal ultrasound revealed non-congenital anomaly in 1 case – it was nephrolithiasis. All the individuals had elevated at least 1 urine indicator of crystallization risk. Conclusion: There is a great need of good, standardized test of renal function in cystic fibrosis patients. The focus of research should turn towards finding a tool similar to faecal elastase, which is cheap, easy to perform, sensitive and specific, and can be used to confirm the diagnosis.
Wstęp: Wraz z wzrastającą długością życia chorych na mukowiscydozę (CF), zaistniała potrzeba radzenia sobie z nowymi jej powikłaniami. Między innymi zaburzenie czynności nerek stało się nowym wyzwaniem. Cel: Ocena czynności nerek u dzieci z mukowiscydozą. Materiał i metody: Przeprowadzono badanie przekrojowe na grupie jedenastu nastoletnich pacjentów z CF hospitalizowanych w IMiDz. U wszystkich przeprowadzono dokładny wywiad dotyczący przebiegu choroby, wywiad rodzinny, badanie fizykalne oraz pomiary czynności nerek. Ocena nerek polegała na oznaczeniu: cystatyny C i kreatyniny w surowicy, klirensu kreatyniny oraz klirensu cystatyny C, wskaźników ryzyka krystalizacji moczu i USG nerek. Wyniki: Jeden pacjent miał podwyższone stężenie cystatyny C w surowicy oraz obniżony klirens cystatyny McIsaaca. W 1 przypadku USG nerek wykazało nieprawidłowość − była to kamica nerkowa. U wszystkich badanych pacjentów co najmniej jeden wskaźnik ryzyka krystalizacji moczu był podwyższony. Wniosek: Istnieje wielka potrzeba dobrego, wystandaryzowanego badania czynności nerek u pacjentów z mukowiscydozą. Przedmiotem badań powinno być znalezienie narzędzia podobnego do oznaczenia stężenia elastazy w kale – testu, który jest łatwy do wykonania, czuły i specyficzny oraz może być stosowany w celu potwierdzenia diagnozy.
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The Reaction of Rat Kidney to Acute Stress Solution of Sodium Chloride in Normal and Occasional Abuse of Thyroid Status
Autorzy:
Zukow, Walery
Dolomatov, Sergey
Kubyshkin, Аnatoliy
Sataieva, Tatiana
Opis:
Walery Zukow
Objective: To study the effectiveness of osmoregulation of renal function in rats with occasional violation of thyroid status in the acute intragastric load of sodium chloride solutions. Materials and Methods: The study was carried out on white male rats, thyroxine was administered once intraperitoneally, 50 mg/100 g body weight. Kidney function was studied in conditions induced diuresis after intragastric administration of stress testing water or 0.3%, 0.8%, 2% and 3% sodium chloride solution in a volume of 5% of body weight. Results: It was found that thyroxin causes a decrease in creatinine clearance and increased renal excretion of endogenous nitrates and nitrites. In control solutions, increasing concentrations of sodium chloride cause progressive increase in glomerular filtration rate values and excretion of osmotically active substances. Discovered a more complex dependence of the values of diuresis and the concentration of NaCl. Minimum performance diuresis recorded using a solution of 0.8% NaCl, and the maximum - in load and aqueous 3% solution of NaCl. Conclusions: 1. The kidneys of rats administered once T4 retain the ability excretion of excessive amounts of liquid and OAB, protecting the internal tissues and organs from hypoosmia and hyperosmotic stress. 2. A single dose of T4 rats can induce switching mechanisms of renal volume regulation and osmoregulation in the phylogenetically ancient tubular type of regulation of fluid excretion by the kidneys and the OAB. 3. For short abuse thyroid status changes in GFR and tubular transport OAB are reversible.
Dostawca treści:
Repozytorium Centrum Otwartej Nauki
Artykuł
Tytuł:
Determinants of long-term outcome in patients after percutaneous stent-assisted intervention on renal artery steno-occlusive atherosclerotic disease
Autorzy:
Rosławiecka, Agnieszka
Przewłocki, Tadeusz
Kabłak-Ziembicka, Anna
Trystuła, Mariusz
Odrowąż-Pieniążek, Piotr
Rzeźnik, Daniel
Badacz, Rafał
Opis:
Introduction: The effect of stent-assisted percutaneous transluminal angioplasty (PTA) for renal artery stenosis (RAS) on systolic (SBP) and diastolic blood pressure (DBP) as well as renal function, in comparison with medical therapy, is still debatable. Data on determinants of cardiovascular (CV) outcome after PTA are lacking. Objectives: We aimed to identify determinants of major cardiac and cerebral events (MACCEs) following PTA for RAS. Patients and methods: A total of 248 PTAs for RAS were performed in 211 patients with difficult-to-treat hypertension and/or progressive renal impairment. The primary outcomes were procedural success, in-hospital complications, renal function (estimated glomerular filtration rate [eGFR]), change in SBP or DBP, and an incidence of MACCEs during a median of 47 months (interquartile range [IQR], 18–78 months). Results: Procedural success and complication rates were 99.2% and 4.7%, respectively. We observed significant differences in SBP, DBP, and eGFR at 12 months as compared with baseline. A total of 63 MACCEs (30.6%) were noted in 206 patients with available follow-up data. The receiver operating characteristic curve analysis indicated the following best cutoff values for the risk of CV death: an increase in eGFR by at least 11 ml/min/1.73 m2 and a decrease in SBP and DBP by at least 20 mm Hg and 5 mm Hg, respectively. At 12-month follow-up, an increase in eGFR of at least 11 ml/min/1.73 m2 was independently associated with a reduced risk of death (hazard ratio [HR], 0.42; 95% CI, 0.19–0.90; P = 0.02) and MACCEs (HR, 0.54; 95% CI, 0.32–0.93; P = 0.03), while a decrease of DBP by 5 mm Hg or higher, with a reduced risk of stroke (HR, 0.1; 95% CI, 0.02–0.39; P = 0.001). Conclusions: This study confirms the efficacy and safety of PTA as well as its significant effect on changes in blood pressure and eGFR values. Patients with an increase in eGFR of at least 11 ml/min/1.73 m2 have a significant risk reduction of MACCEs and CV death, while those with a decrease in DBP of at least 5 mm Hg, of stroke.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Does diffusion-weighted magnetic resonance imaging help in the detection of renal parenchymal disease and staging/prognostication in chronic kidney disease?
Autorzy:
Arora, Vijinder
Singh, Kunwarpal
Khatana, Jasmin
Opis:
Purpose: Diffusion-weighted imaging (DWI) in renal diseases is an upcoming modality, and its utility as an additional marker is yet to be proven. This study was intended to find the relationship between apparent diffusion coefficient (ADC) values with renal function tests and stages of chronic kidney disease (CKD) to assess renal dysfunction, and to label a cut-off for normal renal function and dysfunction. Material and methods: A prospective diagnostic study was conducted on 120 patients: 60 with deranged renal function tests (RFT) and 60 with normal RFT. DWI using a 1.5-Tesla MRI (at b-values of 0 and 500 s/mm2) was done. A region of interest of size 1-2 cm2 was placed on renal parenchyma in the region of medulla, one each, over the superior, mid, and lower regions of each kidney separately. ADC values were recorded for renal parenchyma and compared. Results: In patients with renal dysfunction ADC values were significantly lower than in patients with normal function (1.75 ± 0.25 vs. 2.28 ± 0.21 of right kidney and 1.79 ± 0.17 vs. 2.29 ± 0.21 of left kidney [×10-3 mm2/s]; p = 0.001). ADC values of different stages of CKD showed a decreasing trend with increasing stage. Conclusions: ADC values taken at all poles to get focal involvement of the kidney can be used to measure each kidney separately, and values can be individually correlated with the elevated renal parameters. The cut-off value of the mean ADC for individual kidneys was > 2.28 (×10-3 mm2/s) in normal renal function and < 2.00 (×10-3 mm2/s) in renal dysfunction.
Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Endovascular treatment of renal artery occlusion caused by aortic stentgraft migration
Autorzy:
Stanišić, Michał Goran
Majewska, Natalia
Romanowski, Michał
Kulesza, Jerzy
Juszkat, Robert
Makałowski, Marcin
Majewski, Wacław
Tematy:
abdominal aortic aneurysm
renal function
aortic stentgraft migration
endovascular treatment complication
chimney technique
Pokaż więcej
Wydawca:
Index Copernicus International
Powiązania:
https://bibliotekanauki.pl/articles/1395591.pdf  Link otwiera się w nowym oknie
Opis:
Renal function impairment during interventional procedures became a real clinical problem. Contrast related nephropathy is the most common cause of renal failure, however, the procedure-related technical troubles may cause unexpected renal dysfunction.Technical failure of EVAR resulting in acute renal dysfunction is presented. The postprocedural occlusion of the right renal artery was treated in chimney technique. Early reintervention allowed the kidney preservation and renal function restoration. It is impossible to avoid all the complications following treatment of aortic aneurysm, but they can be anticipated and comprehensively treated in collaboration with other specialists.
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 18

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