Temat: staphostatins - Prolib Integro

Skocz do pozycji: 1.

Artykuł

Skocz do pozycji: 2.

Tytuł:: Modes of inhibition of cysteine proteases.
Autorzy:: Rzychon, Malgorzata
Chmiel, Dorota
Stec-Niemczyk, Justyna
Tematy:: cysteine proteases
serpins
inhibitors
cystatins
staphostatins
proteolysis; Pokaż więcej
Wydawca:: Polskie Towarzystwo Biochemiczne
Powiązania:: https://bibliotekanauki.pl/articles/1041496.pdf Link otwiera się w nowym oknie
Opis:: Cysteine proteases are involved in many physiological processes and their hyperactivity may lead to severe diseases. Nature has developed various strategies to protect cells and whole organisms against undesired proteolysis. One of them is the control of proteolytic activity by inhibition. This paper presents the mechanisms underlying the action of proteinaceous inhibitors of cysteine proteinases and covers propeptides binding backwards relative to the substrate or distorting the protease catalytic centre similarly to serpins, the p35 protein binding covalently to the enzyme, and cystatins that are exosite binding inhibitors. The paper also discusses tyropins and chagasins that, although unrelated to cystatins, inhibit cysteine proteinases by a similar mechanism, as well as inhibitors of the apoptosis protein family that bind in a direction opposite to that of the substrate, similarly to profragments. Special attention is given to staphostatins, a novel family of inhibitors acting in an unusual manner.
Dostawca treści:: Biblioteka Nauki

Artykuł

Skocz do pozycji: 3.

Tytuł:: The staphostatin family of cysteine protease inhibitors in the genus Staphylococcus as an example of parallel evolution of protease and inhibitor specificity
Autorzy:: Chmiel, Dorota
Władyka, Benedykt
Potempa, Jan
Zdżalik, Michał
Dubin, Adam
Steć-Niemczyk, Justyna
Dubin, Grzegorz
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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