Temat: stem cells - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Stem cells: applications, perspectives, misunderstandings
Autorzy:: Dulak, Józef
Tematy:: stem cells
cellular therapies
gene therapy
embryonic stem cells
induced pluripotent stem cells; Pokaż więcej
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Powiązania:: https://bibliotekanauki.pl/articles/704245.pdf Link otwiera się w nowym oknie
Opis:: Stem cells exist and can do a lot. For several decades, bone marrow and umbilical cord blood transplants containing haematopoietic stem cells have been used in the treatment of blood diseases. Genetic modifications (gene therapy) of such cells help to cure complex immunodeficiencies and severe anaemias. The limbal stem cells taken from the eye and properly multiplied can regenerate the damaged cornea, and the epidermal stem cells help in the treatment of severe burns and some hereditary, severe skin diseases. Promising experimental research is under way on other uses of stem cells. However, these cells are appropriately selected, having real ability to differentiate into specialized cells whose malfunction is the cause of the disease. Therapeutic applications of stem cells are apparently limited to date. Meanwhile, the Internet is full of advertisements for supposedly miraculous treatments for almost any disease. Stem cells have become a modern synonym of the Holy Grail. A wonderful dish, transforming every drink into elixir of health, youth and long life. Stem cells from a single source, e.g., umbilical cord blood, or so-called cells, although without proven properties of stem cells, are offered in commercial private clinics as a panacea for autism, cerebral palsy, spina bifida, eye diseases, amyotrophic lateral sclerosis and dozens other disorders. Without justification for their action in these diseases, without convincing evidence of safety, but for a high fee. This article discusses stem cells and misunderstandings about including any cells among them. It draws attention to the real possibilities and confirmed uses of stem cells and presents the problems, doubts and dangers for patients associated with commercial offers of treatments using “stem” cells. The author cites the positions of scientific institutions and societies warning against premature commercialization of unjustified and potentially dangerous therapies
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Autorzy:: Dulak, Józef
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 3.

Tytuł:: Szlaki przekazywania sygnałów komórkowych. XXI Zimowa Szkoła Instytutu Farmakologii PAN, Mogilany 2004. Pod red. Ireny Nalepy
Komórki macierzyste- Potencjalne zastosowanie
Autorzy:: Domańska-Janik, Krystyna
Wydawca:: Instytut Farmakologii PAN
Powiązania:: Zimowa Szkoła Instytutu Farmakologii PAN
bibliogr..
Opis:: 137-145 s., kolor.il.2
Dostawca treści:: RCIN - Repozytorium Cyfrowe Instytutów Naukowych

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Skocz do pozycji: 4.

Autorzy:: Klimeczek-Chrapusta, Maria
Strużyna, Jerzy
Drukała, Justyna
Surowiecka, Agnieszka
Chrapusta, Anna
Korzeniowski, Tomasz
Opis:: Mesenchymal stem cells have a known regenerative potential and are used in many indications. They secrete many growth factors, including for fibroblasts (FGF), endothelium (VEGF), as well as 14 anti-inflammatory cytokines, and they stimulate tissue regeneration, promoting the secretion of proteins and glycosaminoglycans of extracellular matrices, such as collagen I, II, III, and V, elastin, and also metalloproteinases. They secrete exosomes that contain proteins, nucleic acids, lipids, and enzymes. In addition, they show the activity of inactivating free radicals. The aim of this study was an attempt to collect the existing literature on the use of stem cells in the treatment of a burn wound. There were 81 studies included in the analysis. The studies differed in terms of the design, burn wound model, source of stem cells, and methods of cellular therapy application. No major side effects were reported, and cellular therapy reduced the healing time of the burn wound. Few case reports on human models did not report any serious adverse events. However, due to the heterogeneity of the evidence, cellular therapy in burn wound treatment remains an experimental method.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 5.

Tytuł:: Prospects for the use of the achievements of regenerative medicine in otorhinolaryngology
Autorzy:: Ciechanowicz, Andrzej K
Tematy:: regenerative medicine
pluripotent stem cells
embryonic stem cells
very small embryonic-like stem cells
tissue engineering; Pokaż więcej
Wydawca:: Index Copernicus International
Powiązania:: https://bibliotekanauki.pl/articles/1400044.pdf Link otwiera się w nowym oknie
Opis:: Regenerative medicine is focusing on searching for stem cells, which can be efficiently and safely used for regeneration of damaged tissues and organs. Pluripotent stem cells would be ideal for this purpose. It is because they have the ability to differentiate into cells of all three germ layers (ecto-, meso- and endoderm). One of the sources of their isolation are embryos. For many years, they are made unsuccessful attempts to use of very controversial embryonic stem cells that are isolated from embryos. So strong ethical controversy forced scientists to look for other, undoubted ethically, sources of pluripotent stem cells. Induced pluripotent stem cells are proposed, as a more promising alternative to cells isolated from embryos. Unfortunately, both embryonic stem cells and induced pluripotent stem cells tend to genetic instability leading to the formation of teratomas. In parallel studies scientists try to use of stem cells isolated from adult tissues (e.g. bone marrow cells or adipose tissue) in the regeneration of parenchymal organs. Unfortunately, there is no convincing evidence for most of these cells that can regenerate damaged parenchymal organs. Regenerative medicine more frequently is employed in the otorhinolaryngological therapies. More and more researchers’ efforts are put into the development of an effective method of stimulation (in vitro) of pluripotent stem cells isolated from adult tissue for differentiation of the renewable progenitor stem cells which can keep their potential after transplantation into the recipient (e.g. in the treatment of imbalances or hearing loss). Moreover, there are promising methods for employing of the stem cells potential in tissue engineering as they are more effectively introduced as a clinical therapies.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Stem cells are the hope of modern stomatology
Autorzy:: Gabiec, K.
Wyrzykowska, K.
Dąbrowska, Z.
Antoniak, M.
Dąbrowska, E.
Tematy:: Stem cells
stomatology; Pokaż więcej
Wydawca:: Uniwersytet Medyczny w Białymstoku
Powiązania:: https://bibliotekanauki.pl/articles/1918468.pdf Link otwiera się w nowym oknie
Opis:: Introduction: Stem cells are often hailed as the medicine of the 21st century. They provide us with potential tools to effectively counteract not only diseases, but even aging. For stomatology, stem cells are the technology of the future in the regeneration of the periodontium and pulp, and dental replantation and transplantation. Materials and methods: On the basis of a literature review, the previous achievements and potential capabilities of stem cell therapy were discussed, focusing on dental applications. Conclusions: The paper discusses the modulation of stem cells and their therapeutic potential and capabilities. The presence and properties of stem cells in the pulp of human deciduous and permanent teeth, the periodontal membrane and the dental sac are also discussed. The results of the studies conducted by the cited researchers are promising and give hope for the development of regenerative and restorative processes of the dental and periodontal tissues. Summary: In the future, stem cells obtained from primary and permanent teeth deposited in special dental banks will be able to prevent the degradation of periodontal tissue, or even heal the teeth.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Adult stem cells: hopes and hypes of regenerative medicine
Autorzy:: Dulak, Józef
Szade, Krzysztof
Szade, Agata
Nowak, Witold
Józkowicz, Alicja
Tematy:: embryonic stem cells
induced pluripotent stem cells
myocardial infarction
very small embryonic-like stem cells
heme oxygenase-1; Pokaż więcej
Wydawca:: Polskie Towarzystwo Biochemiczne
Powiązania:: https://bibliotekanauki.pl/articles/1038957.pdf Link otwiera się w nowym oknie
Opis:: Stem cells are self-renewing cells that can differentiate into specialized cell type(s). Pluripotent stem cells, i.e. embryonic stem cells (ESC) or induced pluripotent stem cells (iPSC) differentiate into cells of all three embryonic lineages. Multipotent stem cells, like hematopoietic stem cells (HSC), can develop into multiple specialized cells in a specific tissue. Unipotent cells differentiate only into one cell type, like e.g. satellite cells of skeletal muscle. There are many examples of successful clinical applications of stem cells. Over million patients worldwide have benefited from bone marrow transplantations performed for treatment of leukemias, anemias or immunodeficiencies. Skin stem cells are used to heal severe burns, while limbal stem cells can regenerate the damaged cornea. Pluripotent stem cells, especially the patient-specific iPSC, have a tremendous therapeutic potential, but their clinical application will require overcoming numerous drawbacks. Therefore, the use of adult stem cells, which are multipotent or unipotent, can be at present a more achievable strategy. Noteworthy, some studies ascribed particular adult stem cells as pluripotent. However, despite efforts, the postulated pluripotency of such events like "spore-like cells", "very small embryonic-like stem cells" or "multipotent adult progenitor cells" have not been confirmed in stringent independent studies. Also plasticity of the bone marrow-derived cells which were suggested to differentiate e.g. into cardiomyocytes, has not been positively verified, and their therapeutic effect, if observed, results rather from the paracrine activity. Here we discuss the examples of recent studies on adult stem cells in the light of current understanding of stem cell biology.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Adult stem cells : hopes and hypes of regenerative medicine
Autorzy:: Szade, Krzysztof
Nowak, Witold
Józkowicz, Alicja
Szade, Agata
Dulak, Józef
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 9.

Autorzy:: Słuczanowska-Głąbowska, Sylwia
Drukała, Justyna
Staniszewska, Marzena
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 10.

Tytuł:: Krótki przegląd na temat komórek macierzystych
A short overview of stem cells
Autorzy:: Kmiecik, B.
Skotny-Krakowian, A.
Rybak, Z.
Tematy:: embrionalne komórki macierzyste
indukowane pluripotencjalne komórki macierzyste
mezenchymalne komórki macierzyste
embryonic stem cells
induced pluripotent stem cells
mesenchymal stem cells; Pokaż więcej
Wydawca:: Politechnika Wrocławska. Wydział Podstawowych Problemów Techniki. Katedra Inżynierii Biomedycznej
Powiązania:: https://bibliotekanauki.pl/articles/261099.pdf Link otwiera się w nowym oknie
Opis:: Wykorzystanie komórek macierzystych może mieć duży potencjał w medycynie. Stale jednak toczą się debaty, jakie rodzaje komórek macierzystych powinny być w przyszłości wykorzystywane w celach regeneracyjnych. W poniższej pracy dokonano porównania embrionalnych, indukowanych pluripotencjalnych i somatycznych komórek macierzystych. Jednak, by bezpiecznie wykorzystywać komórki macierzyste do regeneracji ciała ludzkiego, należy jeszcze dokładniej poznać mechanizmy ich działania. Z tego powodu Amerykańska Agencja ds. Żywności i Leków (FDA) już w 2006 roku zdecydowała się na opracowanie procedur, które mają zapewnić bezpieczeństwo pacjentom korzystającym z terapii opartych na komórkach macierzystych.
Applications of stem cells has a huge medical potential. However, among scientists there is an ongoing debate, concerning which stem cells should be used in the future for regeneration purposes. This paper presents a comparison of embryonic, induced pluripotent, and somatic stem cells. Gaining a better understanding of the molecular functioning of stem cells will probably lead to more efficient treatment methods for many incurable diseases. For this reason, American agency for Food and Drug Administration (FDA) established some general procedures, which, to some degree, should ensure the safety of experimental stem cell therapies.
Dostawca treści:: Biblioteka Nauki

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