- Tytuł:
- Production of functional transgenic mice by DNA pronuclear microinjection.
- Autorzy:
- Auerbach, Anna
- Tematy:
-
functional transgenics
transgenic mouse production
transgenesis
transgene random integration
pronuclear microinjection - Pokaż więcej
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Powiązania:
- https://bibliotekanauki.pl/articles/1043315.pdf Link otwiera się w nowym oknie
- Opis:
- Successful experiments involving the production of transgenic mice by pronuclear microinjection are currently limited by low efficiency of random transgene integration into the mouse genome. Furthermore, not all transgenic mice express integrated transgenes, or in other words are effective as functional transgenic mice expressing the desired product of the transgene, thus allowing accomplishment of the ultimate experimental goal - in vivo analysis of the function of the gene or gene network. The purpose of this review is to look at the current state of transgenic technology, utilizing a pronuclear microinjection method as the most accepted way of gene transfer into the mouse genome.
- Dostawca treści:
- Biblioteka Nauki
Artykuł