Temat: ulcerative colitis - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Higher Apoptosis Index and Proliferation Index in Colonocytes of Patients with Ulcerative Colitis in Remission
Autorzy:: Buczyński, Jarosław
Spychalski, Michał
Ławska-Wierzchniewska, Agnieszka
Dziki, Adam
Tematy:: apoptosis
proliferation
ulcerative colitis; Pokaż więcej
Wydawca:: Index Copernicus International
Powiązania:: https://bibliotekanauki.pl/articles/1396694.pdf Link otwiera się w nowym oknie
Opis:: Ulcerative colitis (UC) is a inflammatory disease of large bowel. The amount of people suffering from UC increases from year to year. Pathogenesis of this affection is still not entirely clear. Mechanisms of proliferation and apoptosis in colonocytes in the course of the disease are defectedThe aim of the study was to assess the rate of proliferation and intensity of apoptosis in colonocytes in patients with diagnose UC.Material and methods. Colon pathological samples taken from patients with diagnosed ulceraive colitis were examined. Patients were in both clinical and endoscopic remission and were treated with mesalazin. They were patient of Department of General and Colorectal Surgery. To estimate proliferation index dye with monoclonal antibody against Ki67. To determine apoptosis level immunohistochemistry with antybody against Bax was used.Results. Average Ki-67 in the test group was 42,13%, the largest value amounted to 57% and the lowest of 33%. Average value of Bax was 1.47 and ranged between 0-3. High index of bax appear not only in the bottom of the crypt, but also at their outlet.Conclusions. In ulecerative colitis genetic and immunological disturbances occur despite treatment. Mesalazine acting only on certain routes associated with the UC holds the remission, without, however "the molecular remission". Thus, it appears that the results of our research are another proof of the necessary caution in weaning support treatment.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Infliximab in therapy of inflammatory bowels diseases
Autorzy:: Bar, Piotr
Galiniak, Sabina
Bartusik-Aebisher, Dorota
Filip, Rafał
Aebisher, David
Tematy:: infliximab
TNFα
ulcerative colitis; Pokaż więcej
Wydawca:: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Powiązania:: https://bibliotekanauki.pl/articles/454884.pdf Link otwiera się w nowym oknie
Opis:: Introduction. Infliximab is a monoclonal antibody that acts against tumor necrosis factor TNF-α. The drug is used in the treatment of autoimmune diseases. Aim. This article reviewed the efficacy and safety of infliximab for the treatment in severe ulcerative colitis. This review included studies that evaluated the clinical use of infliximab. Material and methods. This meta-analysis was performed according to systematic literature search of three major bibliographic databases (Scopus, PubMed, and Cochran). Results. Infliximab has been approved by the US Food and Drug Administration (FDA) as a medicine to treat Leśniowski and Crohn’s disease, ulcerative colitis, psoriasis, psoriatic arthritis, ankylosing spondylitis, and rheumatoid arthritis. However, further trials are required to compare other parameters of efficacy such as the clinical response with infliximab. Conclusion. In patients suffering from Crohn’s disease or ulcerative colitis under infliximab maintenance therapy, sustained good trough levels are associated with: better response and remission rates, more mucosal healing and less loss of response.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Care of patients with ulcerative colitis.
Opieka nad pacjentem z wrzodziejącym zapaleniem jelita grubego.
Autorzy:: Sędek, Bożena
Opis:: Along with all the changes taking place in the diagnosis and treatment of ulcerative colitis, the changes also apply to nursing care of the patients who stay in the hospital.At present, nurses have a wealth of theoretical knowledge and practical skills. Through observation they can analyse the changing symptoms of disease. They are able to develop a plan of care system starting with their own assessment of patient's state. It includes the observation of the physical, emotional, environmental problems and assessment the problems of body hygiene, nutrition, excretion, and activity of patient.The study includes clinical aspects of ulcerative colitis with the diagnosis, treatment and prevention of relapse. It also defines the problems associated with the illness based on the observation, interview, and test results.
Wraz ze wszystkimi zmianami, jakie zachodzą w diagnostyce i leczeniu wrzodziejącego zapalenia jelita grubego, zmiany dotyczą również opieki pielęgniarskiej sprawowanej nad chorym przebywającym w oddziale szpitalnym.Obecnie pielęgniarki mają duży zasób wiedzy teoretycznej oraz umiejętności praktycznych. Dzięki obserwacji potrafią przeprowadzić analizę zmieniających się objawów choroby. Są w stanie opracować plan opieki rozpoczynając od własnej oceny stanu chorego między innymi obserwacji stanu fizycznego, emocjonalnego, problemów środowiskowych oraz oceny problemów higieny ciała, odżywiania, wydalania i aktywności. W pracy zawarto aspekty kliniczne wrzodziejącego zapalenia jelita grubego z zakresu diagnostyki, leczenia i przeciwdziałania nawrotom oraz zdefiniowano problemy pacjenta związane z chorobą na podstawie obserwacji, wywiadu i wyników badań.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Inne

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Skocz do pozycji: 4.

Tytuł:: Prognostic value of assessment of stool and serum IL-1Β, IL-1ra and IL-6 concentrations in children with active and inactive ulcerative colitis
Autorzy:: Tomasik, Przemysław
Fyderek, Krzysztof
Wędrychowicz, Andrzej
Zając, Andrzej
Opis:: Introduction: Interleukin-1b (IL-1b), interleukin-1 receptor antagonist (IL-1ra) and interleukin-6 (IL-6) contribute to the pathogenesis of ulcerative colitis (UC). The aim of our study was to evaluate the serum and stool IL-1b, IL-1ra and IL-6 concentrations as potential prognostic factors in children with UC. Material and methods: Thirty-eight children with UC (20 active, 18 inactive) and 14 healthy controls were prospectively included in the study. IL-1b, IL-1ra and IL-6 concentrations were measured in serum and stool supernatants at inclusion to the study using ELISA immunoassays. The children were followed up over 5 years, and at each follow-up clinical disease activity, quantity and severity of relapses, nutritional status, endoscopic and histopathologic activity, disease complications and the treatment regimen were evaluated. Results: In children with active and inactive UC who had relapsed during a 5-year follow-up period compared to the non-relapse groups we found significantly increased serum IL-1b (1.34 vs. 0.98 pg/ml, p < 0.05, and 1.02 vs. 0.68 pg/ml, p < 0.01, respectively,) and IL-1ra (718.0 vs. 453.2 pg/ml, p < 0.05, and 567.4 vs. 365.1 pg/ml, p < 0.01, respectively). Additionally, in children who had experienced complications during a 5-year follow-up period we observed significantly increased serum and stool IL-1b (p < 0.05) and serum IL-1ra (p < 0.01) compared to the group without complications. Conclusions: We concluded that serum IL-1b and IL-1ra and to a lesser extend stool IL-1b concentrations may be useful prognostic factors in children with active and inactive UC over a short-term follow-up period, which may help to identify children that require more aggressive therapy due to an increased risk of relapse or complications resulting from UC.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Artykuł

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Skocz do pozycji: 5.

Tytuł:: The influence of socio-demographic and clinical factors on the process of acceptance of the disease among patients with ulcerative colitis
Autorzy:: Chrobak-Bień, Joanna
Gawor, Anna
Paplaczyk, Małgorzata
Małecka-Panas, Ewa
Gąsiorowska, Anita
Tematy:: Acceptance of the disease
ulcerative colitis; Pokaż więcej
Wydawca:: Index Copernicus International
Powiązania:: https://bibliotekanauki.pl/articles/1392911.pdf Link otwiera się w nowym oknie
Opis:: Ulcerative colitis (UC) is a kind of inflammatory bowel disease involving rectal mucosa, or the rectum with colon, resulting in ulcerations in some cases. It is incurable and varies with periods of exacerbation and remission. The disease affects mainly population of highly-developed European or North American nations. It can relatively rarely be observed in South America, Asia and Africa. It is estimated that morbidity and incidence in those regions is about 10 times lower than in Europe and North America [1,2]. The incidence of UC in Europe is approximately 10 new cases per 100,000 people annually [3]. In Poland, epidemiology assessment is difficult due to a lack of reliable statistics. In Lower Silesia, 840 hospitalizations for UC on average are registered annually [4,5]. In UC pathogenesis, genetic, environmental and immunologic factors play an important role. UC can occur at any age, however, the peak incidence is observed between ages 20 and 40 and over 65 [6]. UC is incurable and accompanies the patient through the rest of his/her life. It varies with periods of exacerbation and remission, which impair everyday activities and lower patient’s quality of life. As a consequence, the patient generally feels bad, which is not only caused by gastrointestinal symptoms but also by emotional and psychological issues [7]. Nowadays, a clear tendency can be observed in medicine to include health and disease-related issues in biopsychosocial context, including social and psychological factors affecting the course of the disease. The assessment of such factors brings up a broader perspective on patient’s health problems [8]. Adjustment to the disease is important in many chronic diseases, which demand a change of the patient’s attitude and taking aspects such as acceptance of one’s disease into consideration [9]. The term ‘acceptance’ denotes adopting an opinion, judgment, belief, behavior, favorable attitude or to give a consent [10]. Accepting one’s disease means adjusting to limitations posed by it and accepting the associated disability. The consequences include accepting the limitations, not being self-sufficient, dependence on others and low self-esteem [11]. In a chronic and difficult therapeutic process, medical staff play the key role, in addition to other patient’s support. Bonding with other patients is an important regulating factor in the emotional sphere, while psychological counseling can turn out beneficial in accepting one’s new difficult life situation. The aim of the study was to evaluate the acceptance of the disease in patients with ulcerative colitis with respect to selected socio-demographic and clinical variables.
Dostawca treści:: Biblioteka Nauki

Artykuł

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Skocz do pozycji: 6.

Autorzy:: Mach, Tomasz
Cibor, Dorota
Szczepanek, Małgorzata
Owczarek, Danuta
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 7.

Tytuł:: Met-enkephalins in patients with inflammatory bowel diseases
Autorzy:: Sałapa, Kinga
Owczarek, Danuta
Pierzchała-Koziec, K.
Cieśla, Andrzej
Mach, Tomasz
Kuśnierz-Cabala, Beata
Cibor, Dorota
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

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Skocz do pozycji: 8.

Tytuł:: Determinants of the level of anxiety and fears in a group of patients with ulcerative colitis
Autorzy:: Kózka, Maria
Bodys-Cupak, Iwona
Skowron, Wioletta
Opis:: Introduction. Ulcerative colitis is a chronic, inflammatory disease of the mucous membrane of the large intestine manifesting itself through diarrhoea with blood, mucous and pus. It progresses with periods of relapses and remissions. The treatment is a long-term process which should aim at improving the patient’s clinical condition and quality of life, as well as minimising the disease-related anxiety and fears. Objective. The aim of the study was recognition of the determinants of the level of anxiety and fears in a group of patients with ulcerative colitis. Materials and method. The prospective study comprised 102 patients with diagnosed ulcerative colitis. The data were collected by means of the following tools: Clinical Disease Activity Index, Rating Form of IBD Patients Concerns (RFIPC), and a questionnaire by the authors. Statistical parametric and non-parametric tests were used to analyse the data, depending on the type of scale and nature of the variable distribution. Results. Most of the patients (64%) were in the active phase of the disease. A high level of fear and anxiety occurred in 73% of the patients and concerned the impact of the disease, intimate life, complications and stigmatisation. The highest levels of fears and anxiety were observed in the field of complications and the impact of the disease on the patients’ lives. Conclusions. The disease activity and high levels of anxiety and fears influenced the psychosocial functioning of the patients with ulcerative colitis.
Dostawca treści:: Repozytorium Uniwersytetu Jagiellońskiego

Artykuł

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Skocz do pozycji: 9.

Tytuł:: Determinants of the level of anxiety and fears in a group of patients with ulcerative colitis
Autorzy:: Kózka, M.
Skowron, W.
Bodys-Ciupak, I.
Tematy:: disease activity
ulcerative colitis
anxiety and fears; Pokaż więcej
Wydawca:: Instytut Medycyny Wsi
Powiązania:: https://bibliotekanauki.pl/articles/2083068.pdf Link otwiera się w nowym oknie
Opis:: Introduction. Ulcerative colitis is a chronic, inflammatory disease of the mucous membrane of the large intestine manifesting itself through diarrhoea with blood, mucous and pus. It progresses with periods of relapses and remissions. The treatment is a long-term process which should aim at improving the patient’s clinical condition and quality of life, as well as minimising the disease-related anxiety and fears. Objective. The aim of the study was recognition of the determinants of the level of anxiety and fears in a group of patients with ulcerative colitis. Materials and method. The prospective study comprised 102 patients with diagnosed ulcerative colitis. The data were collected by means of the following tools: Clinical Disease Activity Index, Rating Form of IBD Patients Concerns (RFIPC), and a questionnaire by the authors. Statistical parametric and non-parametric tests were used to analyse the data, depending on the type of scale and nature of the variable distribution. Results. Most of the patients (64%) were in the active phase of the disease. A high level of fear and anxiety occurred in 73% of the patients and concerned the impact of the disease, intimate life, complications and stigmatisation. The highest levels of fears and anxiety were observed in the field of complications and the impact of the disease on the patients’ lives. Conclusions. The disease activity and high levels of anxiety and fears influenced the psychosocial functioning of the patients with ulcerative colitis.
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: Macro and micronutrient deficiency in inflammatory bowel diseases
Autorzy:: Jarmakiewicz, Sara
Piątek, Dominika
Filip, Rafał
Tematy:: Crohn’s disease
IBD
ulcerative colitis
vitamins; Pokaż więcej
Wydawca:: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Powiązania:: https://bibliotekanauki.pl/articles/454753.pdf Link otwiera się w nowym oknie
Opis:: Introduction. Inflammatory bowel disease (IBD) is group of global range inflammatory conditions. There has been a regular increase in the number of IBD cases. Patients exclude whole food groups from their diet fearing the emergence of disease symptoms or due to learning from unreliable sources. Doing so, they might deepen the already existing vitamin deficiencies which occur along with the shortage of many minerals. These deficiencies might intensify the disease process or cause a new one. The most common deficits pointed out by numerous researchers concern vitamin D, calcium, cobalamin, folic acid and iron. It is well worth introducing selenium, zinc and ascorbic acid into a diet because of their immunomodulating effect. Important aspect of the healing process is a personalized diet which is designed to compensate for, or prevent vitamin and mineral deficiencies. Aim. The purpose of the study was to review the literature about vitamin and mineral deficiency in Inflammatory Bowel Diseases. Materials and method. Analysis of literature
Dostawca treści:: Biblioteka Nauki

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